Animal Models

Shared Synaptic Pathophysiology in Syndromic and Nonsyndromic Rodent Models of Autism

Source: 
Science
Date Published: 
September 13, 2012
Abstract: 

A new study finds that faulty neuronal circuits in autistic brains can be corrected even after the “critical window” of brain development.

Simple Worms could Help Unravel Complex Human Brains

Source: 
Simons Foundation Austism Research Initiative
Date Published: 
July 25, 2012
Abstract: 

The nematode "Caenorhabditis elegans" may serve as a useful model to study synapses, the junctions between neurons.

Researchers at MIT Use Zebrafish to Better Understand the Genetics of Autism

Source: 
http://www.sciencedaily.com/releases/2012/06/120619103618.htm
Date Published: 
June 19, 2012
Abstract: 

Researchers at MIT use zebrafish to better understand the genetics of autism.

Seizures in Angelman Syndrome Could be Linked to an Imbalance in Brain Activity

Source: 
UNC School of Medicine
Date Published: 
June 6, 2012
Abstract: 

Researchers led by Dr. Ben Philpot, an ASF funded mentor, at UNC School of Medicine found that seizures in individuals with Angelman syndrome could be linked to an imbalance in brain cell activity. Angelman syndrome exhibits frequent comorbidity with autism spectrum disorders.

New Clinical Study Evaluates First Drug to Show Improvement in Subtype of Autism

Source: 
EurekAlert
Date Published: 
April 26, 2012
Abstract: 

In an important test of one of the first drugs to target core symptoms of autism, researchers at Mount Sinai School of Medicine are undertaking a pilot clinical trial to evaluate insulin-like growth factor (IGF-1) in children who have SHANK3 deficiency (also known as 22q13 Deletion Syndrome or Phelan-McDermid Syndrome), a known cause of autism spectrum disorder (ASD).

Agent Reduces Autism-like Behaviors in Mice

Source: 
NIMH
Date Published: 
April 26, 2012
Abstract: 

National Institutes of Health researchers have reversed behaviors in mice resembling two of the three core symptoms of autism spectrum disorders (ASD). An experimental compound, called GRN-529, increased social interactions and lessened repetitive self-grooming behavior in a strain of mice that normally display such autism-like behaviors, the researchers say.

Mouse Model Provides Clues to Autism

Source: 
PsychCentral
Date Published: 
March 22, 2012
Abstract: 

Vanderbilt scientists report that a disruption in serotonin transmission in the brain may be a contributing factor for autism spectrum disorder (ASD) and other behavioral conditions.

Bone-marrow Transplant Reverses Rett Syndrome in Mice

Source: 
Nature Magazine
Date Published: 
March 17, 2012
Abstract: 

A bone-marrow transplant can treat a mouse version of Rett syndrome, a severe autism spectrum disorder that affects roughly 1 in 10,000–20,000 girls born worldwide (boys with the disease typically die within a few weeks of birth).

New Research Might Help Explain How a Gene Mutation Found in some Autistic Individuals Leads to Difficulties in Processing Auditory Cues and Paying Spatial Attention to Sound.

Source: 
Science Daily
Date Published: 
February 2, 2012
Abstract: 

New research from Cold Spring Harbor Laboratory (CSHL) might help explain how a gene mutation found in some autistic individuals leads to difficulties in processing auditory cues and paying spatial attention to sound.

Brain-Derived Neurotrophic Factor: Finding May Have Implications for Rett Syndrome, Other Neurological Disorders

Source: 
Science Daily
Date Published: 
January 27, 2012
Abstract: 

Researchers at Oregon Health & Science University have discovered that a molecule critical to the development and plasticity of nerve cells -- brain-derived neurotrophic factor (BDNF) -- is severely lacking in brainstem neurons in mutations leading to Rett syndrome, a neurological developmental disorder.