ASF Grantee

Potential Impact of DSM-5 Criteria on Autism Spectrum Disorder Prevalence Estimates

Source: 
JAMA Psychiatry
Date Published: 
January 22, 2013
Abstract: 

Researchers found that estimates of the number of children with ASD might be lower using the current DSM-5 criteria than using the previous criteria. This study looked at information collected by CDC’s Autism and Developmental Disabilities Monitoring (ADDM) Network. This is the first population-based study in the United States to look at what effect the updated ASD criteria in the DSM-5 might have on estimates of the number of children with ASD. One of the advantages of the ADDM Network method is that it does not rely solely on the presence of an ASD diagnosis, but also includes review of records for children who have behaviors consistent with ASDs, even if they do not have a diagnosis. Because of the way the ADDM Network collects data, in the future CDC will be able to use both the previous DSM-IV-TR and the current DSM-5 criteria to estimate the number of children with ASD. CDC will also continue to evaluate the effect of using the DSM-5 on trends in how doctors and other health professionals diagnose ASD and how service providers evaluate and document symptoms as they transition to using the new criteria.

Autism Science Foundation Announces 2013 Grant Recipients

Date Published: 
April 15, 2013
Abstract: 

Today, the Autism Science Foundation, a not-for-profit organization dedicated to funding autism research, announced the recipients of its annual pre- and postdoctoral fellowships, as well as the first recipient of a new 3-year early career award, and the recipient of its first treatment grant. Three postdoctoral and four predoctoral grants will be awarded to student/mentor teams conducting research in autism interventions, etiology, treatment targets, early diagnosis, biomarkers and animal models. Dr. Jill Locke of the University of Pennsylvania was named the recipient of ASF’s first multi-year grant, and Dr. Alex Kolevzon of the Icahn School of Medicine at Mount Sinai will receive ASF’s first treatment award.

Autism Science Foundation Announces
2013 Grant Recipients
Nine new projects to be funded
 
(April 15, 2013 -- New York, NY)—Today, the Autism Science Foundation, a not-for-profit organization dedicated to funding autism research, announced the recipients of its annual pre- and postdoctoral fellowships, as well as the first recipient of a new 3-year early career award, and the recipient of its first treatment grant.  Three postdoctoral and four predoctoral grants will be awarded to student/mentor teams conducting research in autism interventions, etiology, treatment targets, early diagnosis, biomarkers and animal models. Dr. Jill Locke of the University of Pennsylvania was named the recipient of ASF’s first multi-year grant, and Dr. Alex Kolevzon of the Icahn School of Medicine at Mount Sinai will receive ASF’s first treatment award.
 
“The autism community has demanded more research to understand what is causing autism and to develop better treatments,” said ASF President Alison Singer. “We are proud to be able to increase our research funding in response to this national health crisis and we are especially grateful to all our donors and volunteers who have come together to support autism research and make these grants possible.”
This year, the Autism Science Foundation will fund just over $350,000 in grants. In its four years of operation, ASF has funded over $1.1 million in grants. 
 
“ASF attracts outstanding applicants across the board, representing a broad range of perspectives on autism science,” said Dr. Matthew State, Chair of the ASF Scientific Advisory Board and Chairman of the Psychiatry Department at the University of California, San Francisco. “These projects show great potential to move the field forward.”
 
The following projects were selected for 2013 funding:
 
3-Year Early Career Award:
 
Dr. Jill Locke: University of Pennsylvania
Multi-Site, Randomized, Controlled Implementation Trial of an Evidence-Based, Adult and Peer-Mediated Social Skills Intervention for Elementary School Children with Autism Spectrum Disorder
Co-funded with the FAR Fund
 
 
Treatment Grant:
 
Dr. Alexander Kolevzon: Icahn School of Medicine at Mount Sinai
Human Clinical Trial of IGF-1 in Children with Idiopathic ASD
 
 
Postdoctoral Fellowships:
 
Dr. Aimee Badeaux & Dr. Yang Shi: Boston Children’s Hospital
Molecular Characterization of Autism Gene CHD8 in Shaping the Brain Epigenome
 
Dr. Sara Schaafsma & Dr. Donald Pfaff: Rockefeller University
Sex-Specific Gene-Environment Interactions Underlying ASD
 
Dr. Teresa Tavassoli & Dr. Joseph Buxbaum: Icahn School of Medicine at Mount Sinai
Developing a Sensory Reactivity Composite Score for the New DSM-5
 
 
Predoctoral Fellowships:
 
Alexandra Bey & Dr. Yong-hui Jiang: Duke University
The Role of Shank3 in Neocortex Versus Striatum and the Pathophysiology of Autism
 
Ezzat Hashemi & Dr. Veronica Martinez-Cerdeno: University of California, Davis
Alteration of Dendrite and Spine Number and Morphology in the Human Prefrontal Cortex in Autism
 
Jessie Northrup & Dr. Jana Iverson: University of Pittsburgh
Development of Vocal Coordination between Caregivers and Infants at Risk for ASD
 
Russell Port & Dr. Timothy Roberts: University of Pennsylvania
GABA and Gamma-Band Activity: Biomarker for ASD?
 
Learn more about the projects selected for funding at: 
http://www.autismsciencefoundation.org/current-grantees-2013
 
The Autism Science Foundation is a 501(c)(3) public charity. Its mission is to support autism research by providing funding to scientists and organizations conducting autism research. ASF also provides information about autism to the general public and serves to increase awareness of autism spectrum disorders and the needs of individuals and families affected by autism. To learn more about the Autism Science Foundation or to make a donation visit www.autismsciencefoundation.org.  
 
Contact Information:   
Casey Gold
Operations Manager
Autism Science Foundation
212-391-3913
cgold@autismsciencefoundation.org
 

Frequency and Pattern of Documented Diagnostic Features and the Age of Autism Identification

Source: 
Journal of the American Academy of Child & Pediatric Psychiatry
Date Published: 
February 6, 2013
Abstract: 

The age at which a child with autism is diagnosed is related to the particular suite of behavioral symptoms he or she exhibits, according to this study led by an ASF Grantee. Certain diagnostic features, including poor nonverbal communication and repetitive behaviors, were associated with earlier identification of an autism spectrum disorder. Displaying more behavioral features was also associated with earlier diagnosis.

For more information about this study, read the guest blog from the lead author here: http://autismsciencefoundation.wordpress.com/2013/04/09/identifying-asd-...

Astroglial FMRP-Dependent Translational Down-regulation of mGluR5 Underlies Glutamate Transporter GLT1 Dysregulation in the Fragile X Mouse

Source: 
Human Molecular Genetics
Date Published: 
February 7, 2013
Abstract: 

This paper discusses the role fragile X mental retardation protein (FMRP) plays in protein expression in astrocytes, and suggests that FMRP loss in astrocytes may contribute to the development of fragile X.

Timothy Syndrome is Associated with Activity-dependent Dendritic Retraction in Rodent and Human Neurons

Source: 
Nature Neuroscience
Date Published: 
January 13, 2012
Abstract: 

Stanford researchers, including ASF Grantee Alex Shcheglovitov, discovered a key mechanism underlying Timothy syndrome, a disorder associated with ASD.