Autism Research

Autistic-like Behaviour and Cerebellar Dysfunction in Purkinje cell Tsc1 Mutant Mice.

Source: 
Nature
Date Published: 
August 30, 2012
Abstract: 

Researchers found molecular basis for a cerebellar contribution to cognitive disorders such as autism.

Developmental Trajectories of Resting EEG Power: an Endophenotype of Autism Spectrum Disorder.

Source: 
PLoS One
Date Published: 
2012
Abstract: 

Differences in the nature of the trajectories of EEG power represent important endophenotypes of ASD.

Day and nighttime excretion of 6-sulphatoxymelatonin in adolescents and young adults with autistic disorder.

Source: 
PubMed
Date Published: 
Dec 2012
Abstract: 

A deficit in melatonin production is present both at daytime and at nighttime in individuals with autism, particularly in the most severely affected individuals.

The Complement System: An Unexpected Role in Synaptic Pruning During Development and Disease

Source: 
Annual Review of Neuroscience
Date Published: 
2012
Abstract: 

Researchers unexpectedly found that neural complement proteins may have a roll in the elimination of connections between brain cells, potentially driving disease progression.

Autism-associated promoter variant in MET impacts functional and structural brain networks.

Source: 
PubMed
Date Published: 
Sept. 6, 2012
Abstract: 

Findings highlight how genetic stratification may reduce heterogeneity and help elucidate the biological basis of complex neuropsychiatric disorders such as ASD.

Atypical Brain Activation Patterns During a Face-to-Face Joint Attention Game in Adults with Autism Spectrum Disorder.

Source: 
Human Brain Mapping
Date Published: 
April 16, 2012
Abstract: 

Researchers used fMRI while participants played a joint-attention game to better understand the neural correlates of joint attention.

Mutations in BCKD-kinase Lead to a Potentially Treatable form of Autism with Epilepsy.

Source: 
Science
Date Published: 
Oct. 19, 2012
Abstract: 

Researchers identified inactivating mutations in the gene BCKDK (Branched Chain Ketoacid Dehydrogenase Kinase) in consanguineous families with autism, epilepsy, and intellectual disability.

Metabolic imbalance associated with methylation dysregulation and oxidative damage in children with autism.

Source: 
PubMed
Date Published: 
March. 2013
Abstract: 

Oxidative stress and abnormal DNA methylation have been implicated in the pathophysiology of autism. This investigated the dynamics of an integrated metabolic pathway essential for cellular antioxidant and methylation capacity in children with autism.

Anxiety, sensory over-responsivity, and gastrointestinal problems in children with autism spectrum disorders

Source: 
PubMed
Date Published: 
Jan. 2013
Abstract: 

Children with autism spectrum disorders (ASD) experience high rates of anxiety, sensory processing problems, and gastrointestinal (GI) problems; however, the associations among these symptoms in children with ASD have not been previously examined. The current study examined bivariate and multivariate relations among anxiety, sensory over-responsivity, and chronic GI problems in a sample of 2,973 children with ASD enrolled in the Autism Treatment Network (ages 2-17 years, 81.6 % male).

Special Report: Connectivity

Source: 
SFARI
Date Published: 
March 25, 2013
Abstract: 

This special report from the Simons Foundation looks at neural connectivity theories of autism.