Autism Science

A common X-linked inborn error of carnitine biosynthesis may be a risk factor for nondysmorphic autism.

Source: 
PubMed
Date Published: 
May 22, 2012
Abstract: 

Data suggest that dysregulation of carnitine metabolism may be important in nondysmorphic autism; that abnormalities of carnitine intake, loss, transport, or synthesis may be important in a larger fraction of nondysmorphic autism cases; and that the carnitine pathway may provide a novel target for therapy or prevention of autism.

The Geometric Structure of the Brain Fiber Pathways

Source: 
Science
Date Published: 
March 30, 2012
Abstract: 

Using diffusion magnetic resonance imaging, researchers found cerebral fiber pathways formed a rectilinear three-dimensional grid and Cortico-cortical pathways formed parallel sheets of interwoven paths in four nonhuman primate species and in humans.

Autistic-like Behaviour and Cerebellar Dysfunction in Purkinje cell Tsc1 Mutant Mice.

Source: 
Nature
Date Published: 
August 30, 2012
Abstract: 

Researchers found molecular basis for a cerebellar contribution to cognitive disorders such as autism.

Developmental Trajectories of Resting EEG Power: an Endophenotype of Autism Spectrum Disorder.

Source: 
PLoS One
Date Published: 
2012
Abstract: 

Differences in the nature of the trajectories of EEG power represent important endophenotypes of ASD.

Day and nighttime excretion of 6-sulphatoxymelatonin in adolescents and young adults with autistic disorder.

Source: 
PubMed
Date Published: 
Dec 2012
Abstract: 

A deficit in melatonin production is present both at daytime and at nighttime in individuals with autism, particularly in the most severely affected individuals.

The Complement System: An Unexpected Role in Synaptic Pruning During Development and Disease

Source: 
Annual Review of Neuroscience
Date Published: 
2012
Abstract: 

Researchers unexpectedly found that neural complement proteins may have a roll in the elimination of connections between brain cells, potentially driving disease progression.

Autistic-like behaviours and hyperactivity in mice lacking ProSAP1/Shank2.

Source: 
PubMed
Date Published: 
April 29, 2012
Abstract: 

It is proposed that appropriate therapies for autism spectrum disorders are to be carefully matched to the underlying synaptopathic phenotype.

Autism-associated promoter variant in MET impacts functional and structural brain networks.

Source: 
PubMed
Date Published: 
Sept. 6, 2012
Abstract: 

Findings highlight how genetic stratification may reduce heterogeneity and help elucidate the biological basis of complex neuropsychiatric disorders such as ASD.

Special Report: Connectivity

Source: 
SFARI
Date Published: 
March 25, 2013
Abstract: 

This special report from the Simons Foundation looks at neural connectivity theories of autism.

Association of Maternal Exposure to Childhood Abuse With Elevated Risk for Autism in Offspring

Source: 
JAMA Psychiatry
Date Published: 
March 20, 2013
Abstract: 

This study examined the relationship between maternal childhood abuse and autism in children in a large population-based sample. Maternal abuse was significantly associated with increased autism risk even after researchers controlled for perinatal risk factors, including gestational diabetes, smoking during pregnancy, preeclampsia, exposure to intimate partner violence and premature birth.