Autism Science

Advancing maternal age is associated with increasing risk for autism: a review and meta-analysis.

Source: 
PubMed
Date Published: 
May 2012
Abstract: 

Results of this meta-analysis support an association between advancing maternal age and risk of autism. The RR increased monotonically with increasing maternal age. The association persisted after the effects of paternal age and other potential confounders had been considered, supporting an independent relation between higher maternal age and autism.

De novo mutations revealed by whole-exome sequencing are strongly associated with autism.

Source: 
PubMed
Date Published: 
April 4, 2012
Abstract: 

Among a total of 279 identified de novo coding mutations, there is a single instance in probands, and none in siblings, in which two independent nonsense variants disrupt the same gene, SCN2A (sodium channel, voltage-gated, type II, α subunit), a result that is highly unlikely by chance.

Sporadic autism exomes reveal a highly interconnected protein network of de novo mutations.

Source: 
PubMed
Date Published: 
April 4, 2012
Abstract: 

Results indicate extreme locus heterogeneity but also provide a target for future discovery, diagnostics and therapeutics.

Multiplex targeted sequencing identifies recurrently mutated genes in autism spectrum disorders.

Source: 
PubMed
Date Published: 
December 21, 2012
Abstract: 

Data supports associations between specific genes and reciprocal subphenotypes (CHD8-macrocephaly and DYRK1A-microcephaly) and replicate the importance of a β-catenin-chromatin-remodeling network to ASD etiology.

Is Medication Information for Children with Autism Spectrum Disorder Monitored and Coordinated Across Professionals? Findings from a Teacher Survey

Source: 
School Mental Health
Date Published: 
March 1, 2013
Abstract: 

This study examined school-based medication monitoring in children with ASD. Researchers found that less than half of teachers of medicated students were aware that students were taking medication and no teachers were communicating with prescribing physicians about student behavior and side effects. Since monitoring medication across settings helps physicians assess drug safety and effectiveness, the authors argue for increased communication among professionals.

Patterns and rates of exonic de novo mutations in autism spectrum disorders.

Source: 
PubMed
Date Published: 
April 4, 2012
Abstract: 

Control study provide strong evidence in favour of CHD8 and KATNAL2 as genuine autism risk factors.

Levels of select PCB and PBDE congeners in human postmortem brain reveal possible environmental involvement in 15q11-q13 duplication autism spectrum disorder.

Source: 
PubMed
Date Published: 
October 2012
Abstract: 

Results demonstrate a novel paradigm by which specific POPs may predispose to genetic copy number variation of 15q11-q13.

CNVs: harbingers of a rare variant revolution in psychiatric genetics.

Source: 
PubMed
Date Published: 
March 16, 2012
Abstract: 

CNV studies reflects the nature of rare alleles in general and will serve as a guide as we move forward into a new era of whole-genome sequencing.

Migration and autism spectrum disorder: population-based study.

Source: 
PubMed
Date Published: 
August 2012
Abstract: 

Children of migrant parents may be at greater risk of low-functioning autism spectrum disorder, but lower risk of high-functioning autism spectrum disorder.

A Research Strategy to Discover the Environmental Causes of Autism and Neurodevelopmental Disabilities

Source: 
Environmental Health Perspectives
Date Published: 
July 2, 2012
Abstract: 

It is intended to focus research in environmental causation of NDDs on a short list of chemicals where concentrated study has high potential to generate actionable findings in the near future. Its ultimate purpose is to catalyze new evidence-based programs for prevention of disease in America’s children.