Researchers at Vanderbilt University reviewed the effectiveness of early intervention programs for children aged 12 and younger with Autism Spectrum Disorders (ASDs). Overall, the strength of the evidence ranged from insufficient to low. Studies performed at the University of California Los Angeles /Lovaas-based interventions and variants reported clinically significant gains in language and cognitive skills in some children, as did 1 randomized control trial of an early intensive developmental intervention approach (the Early Start Denver Model). Data suggests that subgroups of children displayed more prominent gains across studies, but common characteristics of those who experienced greater gains are not understood. Studies into the effectiveness of Early Intervention programs demonstrated some progress in cognitive performance, language skills, and adaptive behavior skills in some young children with ASDs, but there is limited literature available on the topic.