Brain Development

Brain Imaging Study Shows Decreased Production of Chemical Messenger GABA in Individuals with Autism

Source: 
Neuroimage
Date Published: 
May 23, 2013
Abstract: 

A new brain imaging study shows that children with autism have low levels of GABA, a chemical that keeps brain signals in check. This is the third study in two years that supports the theory of decreased production of GABA.

Brain Imaging Reveals Thicker Cortex with More Folds in Autism Brains

Source: 
Brain: A Journal of Neurology
Date Published: 
June 2013
Abstract: 

Brain imaging study reveals individuals with autism have a ticker cortex with more folds. This suggests that differences in cognitive abilities of people with autism could be due to unique brain structures.

Compared to What? Early Brain Overgrowth in Autism and the Perils of Population Norms

Source: 
Biological Psychiatry
Date Published: 
May 23, 2013
Abstract: 

A new report questions the evidence for atypical early brain growth in ASD, suggesting reports of abnormal head circumference (HC) growth may be due to a systematic bias in common HC norms rather than dysregulated early brain growth in ASD. The authors encourage future studies to use comparison data from typically developing and clinical control samples and several growth norms in parallel to avoid bias.

Autism Spectrum Disorder Is Associated with Ventricular Enlargement in a Low Birth Weight Population

Source: 
Journal of Pediatrics
Date Published: 
February 13, 2013
Abstract: 

This new study in the Journal of Pediatrics links ventricular enlargement in the brains of low-birth-weight neonates to ASD.

A Quantitative Link between Face Discrimination Deficits and Neuronal Selectivity for Faces in Autism

Source: 
NeuroImage: Clinical
Date Published: 
March 15, 2013
Abstract: 

In this fMRI study of adults with ASD, reduced neuronal selectivity for faces was linked to greater behavioral deficits in face recognition.

Developmental Trajectories of Resting EEG Power: an Endophenotype of Autism Spectrum Disorder.

Source: 
PLoS One
Date Published: 
2012
Abstract: 

Differences in the nature of the trajectories of EEG power represent important endophenotypes of ASD.

Special Report: Connectivity

Source: 
SFARI
Date Published: 
March 25, 2013
Abstract: 

This special report from the Simons Foundation looks at neural connectivity theories of autism.

Developmental Meta-Analysis of the Functional Neural Correlates of Autism Spectrum Disorders

Source: 
Journal of the American Academy of Child and Adolescent Psychiatry
Date Published: 
December 26, 2012
Abstract: 

According to this recent meta-analysis of fMRI studies, autism-related changes in brain activity may continue to develop with age.

Astroglial FMRP-Dependent Translational Down-regulation of mGluR5 Underlies Glutamate Transporter GLT1 Dysregulation in the Fragile X Mouse

Source: 
Human Molecular Genetics
Date Published: 
February 7, 2013
Abstract: 

This paper discusses the role fragile X mental retardation protein (FMRP) plays in protein expression in astrocytes, and suggests that FMRP loss in astrocytes may contribute to the development of fragile X.