Diagnosis

New Genetic Risk Factor for Both Autism and Schizophrenia

Source: 
Science Daily
Date Published: 
November 4, 2010
Abstract: 

Researchers have uncovered a prominent genetic risk factor for autism spectrum disorders and schizophrenia is a small genomic deletion. Remarkably, they found the same deletion on chromosome 17 in 24 separate patients. This CNV was absent in 52,448 controls, making the finding statistically significant. Someone with this deletion is 13.58 times more likely to develop ASD or schizophrenia than is someone lacking this CNV. This gene mutation is also known to cause kidney disease (renal cysts and diabetes syndrome, RCAD).

Language Delays Found in Siblings of Children with Autism

Source: 
Medical News Today
Date Published: 
October 3, 2010
Abstract: 

A new study, led by researchers at Washington University School of Medicine in St. Louis, found mild traits, not strong enough to provoke a diagnosis of autism, seem to be present in the siblings of affected children at significantly higher rates than seen in the general population.

Siblings of children with autism have more frequent language delays and other subtle characteristics of the disorder than previously understood. Girls also may be mildly affected more often than recognized in the past.

Link to Autism in Boys Found in Missing DNA

Source: 
Science Daily
Date Published: 
September 15, 2010
Abstract: 

If a boy's X-chromosome is missing the PTCHD1 gene or other nearby DNA sequences, they will be at high risk of developing ASD or intellectual disability. Girls are different in that, even if they are missing one PTCHD1 gene, by nature they always carry a second X-chromosome, shielding them from ASD.

Misfolded Neural Proteins Linked to Autism Disorders

Source: 
Science Daily
Date Published: 
September 11, 2010
Abstract: 

An international team of scientists, led by researchers at the University of California, San Diego, has identified misfolding and other molecular anomalies in a key brain protein associated with autism spectrum disorders.

Infants Gaze May Be an Early, but Subtle, Marker for Autism Risk

Source: 
Science Daily
Date Published: 
September 1, 2010
Abstract: 

Kennedy Krieger Institute have announced new study results showing an early marker for later communication and social delays in infants at a higher-risk for autism may be infrequent gazing at other people when unprompted. The study also found that six-month-old high-risk infants demonstrated the same level of cause and effect learning skills when compared to low-risk infants of the same age.

Study: Autism Can Be Diagnosed with 15 Minute Brain Scan

Source: 
Bloomberg
Date Published: 
August 10, 2010
Abstract: 

A 15-minute brain scan identified adults with autism almost as effectively as conventional methods of diagnosis that rely on interviews with patients and their families, U.K. scientists said. The scan detected more than 90 percent of the autistic patients who had been diagnosed using intelligence tests, psychiatric interviews, physical examinations and blood tests, according to a study by King’s College London researchers.

Researchers Find Predictors of Autism That Can Lead to Infant Diagnosis

Source: 
S.I. Live
Date Published: 
August 5, 2010
Abstract: 

Certain behaviors seen in infants as young as 1-month-old may be predictors of autism spectrum disorders, according to new research by scientists at the Institute for Basic Research and Developmental Disabilities, Willowbrook.

At 1 month, children with the ASD diagnosis were more likely to have asymmetrical visual tracking and arm tone deficits. By 4 months, they were more attracted to higher levels of visual stimulation, much like younger infants. Between 7 and 10 months, the children with ASD showed major declines in mental and motor performance.

Changes in Autism Spectrum Disorder Prevalance in 4 Areas in the United States

Source: 
Diability and Health Journal, Rice et al
Date Published: 
July 2010
Year Published: 
2010

Study sought to describe autism spectrum disorder (ASD) population characteristics and changes in identified prevalence across 3 time periods.  Children with a potential ASD were identified through records abstraction at multiple sources with clinician review based on Diagnostic and Statistical Manual (DSM-IV-TR) criteria. Multisite, population-based data from the Autism and Developmental Disabilities Monitoring (ADDM) Network were analyzed from areas of Arizona (AZ), Georgia (GA), Maryland (MD), and South Carolina (SC). Participants were 8-year-old children (born in 1992, 1994, or 1996) in 2000, 2002, or 2004 (and children born in 1988 residing in metropolitan Atlanta in 1996) who had been evaluated for a variety of developmental concerns at education and/or health sources.  There was a trend toward increase in identified ASD prevalence among 8-year-old children who met the surveillance case definition in 3 of the 4 study sites from 2000 to 2004. Some of the observed increases are due to improved ascertainment; however, a true increase in ASD symptoms cannot be ruled out. These data confirm that the prevalence of ASDs is undergoing significant change in some areas of the United States and that ASDs continue to be of urgent public health concern.

IntegraGen Announces Publication of Four Genetic Variants in Autism

Source: 
Medical News Today
Date Published: 
May 14, 2010
Abstract: 

IntegraGen SA, a French biotechnology company dedicated to gene discovery, announced today the publication of the results of a collaborative study reporting the use of a combined analysis of multiple genetic variants in a genetic score to help identify individuals at high risk of developing autism.

No Link Between Childhood Infections, Autism

Source: 
Bloomberg Businessweek
Date Published: 
May 7, 2010
Abstract: 

Infections during infancy or childhood do not seem to raise the risk of autism, new research finds. The study found that children who were admitted to the hospital for an infectious disease, either bacterial or viral, were more likely to receive a diagnosis of autism spectrum disorder. However, children admitted to the hospital for non-infectious diseases were also more likely to be diagnosed with autism than kids who were never hospitalized, the study found.