Diagnosis

Blood-based Gene Expression Signatures of Infants and Toddlers with Autism.

Source: 
Journal of the American Academy of Child and Adolescent Psychiatry
Date Published: 
September 2012
Abstract: 

"OBJECTIVE: Autism spectrum disorders (ASDs) are highly heritable neurodevelopmental disorders that onset clinically during the first years of life. ASD risk biomarkers expressed early in life could significantly impact diagnosis and treatment, but no transcriptome-wide biomarker classifiers derived from fresh blood samples from children with autism have yet emerged.

RESULTS: Potential ASD biomarkers were discovered in one-half of the sample and used to build a classifier, with high diagnostic accuracy in the remaining half of the sample."

Infant Neural Sensitivity to Dynamic Eye Gaze Is Associated With Later Emerging Autism

Source: 
Current Biology
Date Published: 
February 21, 2012
Abstract: 

"Autism spectrum disorders (henceforth autism) are diagnosed in around 1% of the population [1]. Familial liability confers risk for a broad spectrum of difficulties including the broader autism phenotype (BAP) [2, 3]. There are currently no reliable predictors of autism in infancy, but characteristic behaviors emerge during the second year, enabling diagnosis after this age [4, 5]. Because indicators of brain functioning may be sensitive predictors, and atypical eye contact is characteristic of the syndrome [6-9] and the BAP [10, 11], we examined whether neural sensitivity to eye gaze during infancy is associated with later autism outcomes [12, 13]. We undertook a prospective longitudinal study of infants with and without familial risk for autism. At 6-10 months, we recorded infants' event-related potentials (ERPs) in response to viewing faces with eye gaze directed toward versus away from the infant [14]. Longitudinal analyses showed that characteristics of ERP components evoked in response to dynamic eye gaze shifts during infancy were associated with autism diagnosed at 36 months. ERP responses to eye gaze may help characterize developmental processes that lead to later emerging autism. Findings also elucidate the mechanisms driving the development of the social brain in infancy."

Toward Brief “Red Flags” for Autism Screening: The Short Autism Spectrum Quotient and the Short Quantitative Checklist for Autism in Toddlers in 1,000 Cases and 3,000 Controls

Source: 
Journal of the American Academy of Child and Adolescent Psychiatry
Date Published: 
February 2012
Abstract: 

Ten items were taken from the Autism Spectrum Quotient (AQ) and the Quantitative Checklist for Autism in Toddlers (Q-CHAT) to develop brief screening tools for ASD. Researchers hope these new measures will help doctors decide whether to refer families for full diagnostic assessments.

A Better Early Blood Test for Autism

Source: 
The Sacramento Bee
Date Published: 
December 5, 2012
Abstract: 

Researchers at Boston's Children Hospital claim a new blood test outperforms existing genetic tests for diagnosing ASD.

Asperger's Won't Appear in Revised Diagnosis Manual

Source: 
ABC News
Date Published: 
December 3, 2012
Abstract: 

Autism Science Foundation President Alison Singer discusses DSM-V changes.

DSM V Final Diagnostic Criteria Approved by APA Board of Trustees

Source: 
Psychiatric News
Date Published: 
November 1, 2012

Diagnosing Autism in Neurobiological Research Studies

Source: 
Behavioural Brain Research
Date Published: 
November 12, 2012
Abstract: 

This review by Catherine Lord and Rebecca Jones looks at common tools and best practices for ASD diagnosis in research settings.

Prevalence and Correlates of Autism in a State Psychiatric Hospital

Source: 
Autism
Date Published: 
November 15, 2012
Abstract: 

This study estimated the ASD prevalence in a psychiatric hospital and evaluated the Social Responsiveness Scale (SRS) combined with other information for differential diagnosis. Undiagnosed ASD may be common in psychiatric hospitals. The SRS, combined with other information, may discriminate well between ASD and other disorders.

Nature Outlook: Autism Now Available Online

Source: 
Nature
Date Published: 
October 31, 2012
Abstract: 

Sponsored in part by ASF, the new Nature Outlook supplement on autism features articles on genetics, adulthood, brain imaging, diagnosis and more.

New Rules Allow Joint Diagnosis of Autism, Attention Deficit

Source: 
SFARI
Date Published: 
October 25, 2012
Abstract: 

Autism and ADHD diagnoses will no longer be mutually exclusive under proposed DSM-5 guidelines. Clinicians will be permitted to make official dual diagnoses when necessary.