Please join us for an IACC Full Committee meeting that will take place on Tuesday, July 8, 2014 from 9:00 a.m. to 5:00 p.m. ETat The Neuroscience Center, 6001 Executive Boulevard, Conference Rooms C and D, Rockville, Maryland 20852.
Onsite registration will begin at 8:00a.m.
Agenda: The committee will discuss committee business, agency updates and issues related to autism spectrum disorder (ASD) research and services activities.
The Neuroscience Center
6001 Executive Boulevard, Conference Rooms C and D
Rockville, Maryland 20852
Nearest Metro stop:
White Flint Metro Station – Red Line
In the interest of security, visitors will be asked to show one form of identification (for example, a government-issued photo ID, driver’s license, or passport) and to state the purpose of their visit upon entrance to the Neuroscience Center.
The meeting will be open to the public and pre-registration is recommended. Seating will be limited to the room capacity and seats will be on a first come, first served basis, with expedited check-in for those who are pre-registered. Please visit the IACC website for access and information about registering.
Public Comment – Deadlines:
Notification of intent to present oral comments: Monday, June 30th by 5:00p.m. ET
Submission of written/electronic statement for oral comments: Tuesday, July 1st by 5:00p.m. ET
Submission of written comments: Tuesday, July 1st by 5:00p.m. ET
The meeting will be remotely accessible by videocast (http://videocast.nih.gov/) and conference call. Members of the public who participate using the conference call phone number will only be able to listen to the meeting.
Individuals who participate using this service and who need special assistance, such as captioning of the conference call or other reasonable accommodations, should submit a request to the contact person listed below at least five days prior to the meeting. If you experience any technical problems with the conference call, please e-mail at firstname.lastname@example.org or call the IACC Technical Support Help Line at 415-652-8023.
Please visit the IACC Events page for the latest information about the meeting, including registration, remote access information, the agenda, materials and information about prior IACC events.
The 2013 Strategic Plan Update provides an accounting and overview of the funding and scientific progress in the autism field since the release of the first IACC Strategic Plan in 2009. The 2013 Update describes recent advances in the scientific understanding of ASD, provides information on the progress of each of the 78 IACC Strategic Plan objectives, highlights areas of need and opportunity, and identifies overarching themes that will be important for future advancement of ASD research. In this final version, you will find a single, streamlined table for each Strategic Plan Question that displays both cumulative 5-year funding and notes regarding progress of each objective, which we thought would be helpful to readers.
The 2013 IACC Strategic Plan Update and related materials are available on the IACC website, www.iacc.hhs.gov:
Antibodies directed against fetal brain proteins of 37 and 73 kDa molecular weight are found in approximately 12% of mothers who have children with autism spectrum disorder (ASD), but not in mothers of typically developing children. This finding has raised the possibility that these immunoglobulin G (IgG) class antibodies cross the placenta during pregnancy and impact brain development, leading to one form of ASD. We evaluated the pathogenic potential of these antibodies by using a nonhuman primate model. IgG was isolated from mothers of children with ASD (IgG-ASD) and of typically developing children (IgG-CON). The purified IgG was administered to two groups of female rhesus monkeys (IgG-ASD; n=8 and IgG-CON; n=8) during the first and second trimesters of pregnancy. Another control group of pregnant monkeys (n=8) was untreated. Brain and behavioral development of the offspring were assessed for 2 years. Behavioral differences were first detected when the macaque mothers responded to their IgG-ASD offspring with heightened protectiveness during early development. As they matured, IgG-ASD offspring consistently deviated from species-typical social norms by more frequently approaching familiar peers. The increased approach was not reciprocated and did not lead to sustained social interactions. Even more striking, IgG-ASD offspring displayed inappropriate approach behavior to unfamiliar peers, clearly deviating from normal macaque social behavior. Longitudinal magnetic resonance imaging analyses revealed that male IgG-ASD offspring had enlarged brain volume compared with controls. White matter volume increases appeared to be driving the brain differences in the IgG-ASD offspring and these differences were most pronounced in the frontal lobes.