Protein

Researchers at MIT Use Zebrafish to Better Understand the Genetics of Autism

Source: 
http://www.sciencedaily.com/releases/2012/06/120619103618.htm
Date Published: 
June 19, 2012
Abstract: 

Researchers at MIT use zebrafish to better understand the genetics of autism.

Scientists Link Evolved, Mutated Gene Module to Syndromic Autism

Source: 
Science Daily
Date Published: 
January 26, 2012
Abstract: 

A team led by researchers at the University of California, San Diego School of Medicine reports that newly discovered mutations in an evolved assembly of genes cause Joubert syndrome, a form of syndromic autism.

Autism may be linked to abnormal immune system characteristics and novel protein fragment

Source: 
MedicalXpress
Date Published: 
January 3, 2012
Abstract: 

Immune system abnormalities that mimic those seen with autism spectrum disorders have been linked to the amyloid precursor protein (APP), reports a research team from the University of South Florida's Department of Psychiatry and the Silver Child Development Center.

Protein Interactome Reveals Converging Molecular Pathways

Source: 
Science Translational Medicine
Date Published: 
June 8, 2011
Year Published: 
2011

A recent study sheds light on how a variety of different mutations in genes that seemingly have little in common can each result in the symptoms of autism. To answer this question, researchers developed a molecular map of protein networks or "interactome" to identify how proteins associated with ASD interact with hundreds of other proteins. Researchers used genes known to be associated with syndromic autism as a starting point for building the interactome. Syndromic autism occurs as part of a broader genetic disorder such as fragile X, Angelman syndrome, and Rett syndrome -- understanding protein interactions with syndromic autism may give insight into idiopathic autism, or autism with no known cause. Using 26 genes associated with syndromic autism, researchers hypothesized that the seemingly dissimilar genes might interact with shared partners in common molecular pathways, leading to the symptoms of autism. Indeed, researchers identified a complex network of 539 proteins that interacted with the autism-related proteins, successfully demonstrating that all of the proteins linked to autism are connected by interactions with common partners. The interactome confirmed previously suspected gene relationships and several new pairings, such as the connection between SHANK3 and TSC1, which share 21 common protein partners. Researchers then performed a microarray analysis on 288 individuals with idiopathic autism in a search for genes within the interactome. They identified three novel copy number variations -- chromosomal deletions and duplications -- on genes found in the network, demonstrating that the interactome may help to identify new genes related to ASD and understand complicated genetic variation.

--IACC 2011 Summary of Advances in ASD Research

Neural Stem Cells Retain High Levels on Reactive Oxygen Species, Study Finds

Source: 
Science Daily
Date Published: 
January 6, 2011
Abstract: 

Researchers at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research have shown for the first time that neural stem cells, the cells that give rise to neurons, maintain high levels of ROS to help regulate normal self-renewal and differentiation. These findings may have significant implications for brain repair and abnormal brain development.

Study Links Immune Protein to Abnormal Brain Development

Source: 
Medical News Today
Date Published: 
October 15, 2010
Abstract: 

Insight into the role that MHC plays in the nervous system and may enhance our understanding of the factors that can contribute to neuropsychiatric disorders like autism and schizophrenia. Increased levels of a protein called major histocompatibility complex, or MHC, in fetal neurons may be a factor development of autism or schizophrenia.

Misfolded Neural Proteins Linked to Autism Disorders

Source: 
Science Daily
Date Published: 
September 11, 2010
Abstract: 

An international team of scientists, led by researchers at the University of California, San Diego, has identified misfolding and other molecular anomalies in a key brain protein associated with autism spectrum disorders.