Siblings

Occurrence and Family Impact of Elopement in Children with Autism Spectrum Disorders

Source: 
Pediatrics
Date Published: 
November, 2012
Year Published: 
2012
Abstract: 

This study assessed parent-reported elopement occurrence and associated factors among children with Autism Spectrum Disorders (ASD)s.

De novo mutations revealed by whole-exome sequencing are strongly associated with autism.

Source: 
PubMed
Date Published: 
April 4, 2012
Abstract: 

Among a total of 279 identified de novo coding mutations, there is a single instance in probands, and none in siblings, in which two independent nonsense variants disrupt the same gene, SCN2A (sodium channel, voltage-gated, type II, α subunit), a result that is highly unlikely by chance.

Examining and Interpreting the Female Protective Effect against Autistic Behavior

Source: 
Proceedings of the National Academy of Sciences
Date Published: 
February 19, 2013
Abstract: 

This study examined the hypothesis that a protective component of the female sex protects females from autistic behavioral impairment. The results indicate that greater familial risk may be associated with ASD in females, and males may require fewer familial risk factors to reach a similar impairment threshold. The authors hope the study will provide insight into the ASD sex ratio and aid future genetic research.

Autism’s Invisible Victims: The Siblings

Source: 
Time
Date Published: 
November 30, 2012
Abstract: 

Earlier this week, Rep. Darrell Issa, Chairman of the Committee on Oversight & Government Reform held a hearing on how the federal government can better respond to the dramatic rise in autism rates. Yet for all this concern, one large affected group is being routinely overlooked: the siblings.

Object Exploration at 6 and 9 Months in Infants with and without Risk for Autism

Source: 
Autism
Date Published: 
November 22, 2012
Abstract: 

Co-authored by ASF grantee Nina Leezenbaum, this study found delayed visual and oral exploration of objects in infant siblings of children with autism that were not observed in infants with no family history.

Atypical Activation During the Embedded Figures Task as a Functional Magnetic Resonance Imaging Endophenotype of Autism

Source: 
Brain
Date Published: 
October 11, 2012
Abstract: 

This study uncovers a possible fMRI endophenotype of autism, showing that compared to typically developing controls with no family history of ASD, adolescents with autism and non-autistic siblings had atypical patterns of brain activation during the Embedded Figures Task.

The Development of Referential Communication and Autism Symptomatology in High-Risk Infants

Source: 
Infancy
Date Published: 
October 1, 2012
Abstract: 

This study suggests that non-verbal communication delays in infants with autistic siblings can predict later ASD symptoms.

For a Science Daily article on this paper, click here: http://www.sciencedaily.com/releases/2012/10/121001124802.htm

Immunization Uptake in Younger Siblings of Children with Autism Spectrum Disorder.

Source: 
Autism
Date Published: 
October 8, 2012
Abstract: 

Study finds that parents who already have one child with autism spectrum disorder may delay or decline immunization for their younger children, potentially placing them at increased risk of preventable infectious diseases.

Background: Parental concerns persist that immunization increases the risk of autism spectrum disorder, resulting in the potential for reduced uptake by parents of younger siblings of children with autism spectrum disorder ("younger sibs").Objective: To compare immunization uptake by parents for their younger child relative to their older child with autism spectrum disorder ("proband") and controls.Design: Immunization status was obtained for 98 "younger sibs," 98 "probands," and 65 controls.Results: A significant group difference emerged for overall immunization status (Fisher's exact test = 62.70, p < .001). One or more immunizations in 59/98 younger sibs were delayed (47/98; 48%) or declined (12/98; 12.2%); immunizations were delayed in 16/98 probands (16.3%) and declined in only one. All controls were fully immunized, with only 6 (9.2%) delayed. Within the "younger sibs" group, 25/98 received an autism spectrum disorder diagnosis; 7 of whom (28%) were fully immunized. The rates of autism spectrum disorder diagnosis did not differ between immunized and nonimmunized younger sib groups, although small sample size limits interpretability of this result.Conclusion: Parents who already have one child with autism spectrum disorder may delay or decline immunization for their younger children, potentially placing them at increased risk of preventable infectious diseases.

IACC Releases Its 2011 Summary of Advances in Autism Spectrum Disorder Research

Source: 
IACC
Date Published: 
April 2, 2012
Abstract: 

On April 2, in honor of the fifth annual World Autism Awareness Day and HHS Autism Awareness Month the IACC has released its annual list of scientific advances that represent significant progress in the field.

New Data Show Children With Autism Bullied Three Times More Frequently Than Their Unaffected Siblings

Source: 
MarketWatch
Date Published: 
March 26, 2012
Abstract: 

Today, the Interactive Autism Network (IAN), www.ianproject.org , the nation's largest online autism research initiative and a project of the Kennedy Krieger Institute, reports preliminary results of the first national survey to examine the impact of bullying on children with autism spectrum disorders (ASD). The results show that 63 percent of children with ASD have been bullied at some point in their lives. These children, who are sometimes intentionally "triggered" into meltdowns or aggressive outbursts by peers, are bullied three times more frequently than their siblings who do not have ASD.