Treatments

Modeling Autism in a Dish

Source: 
Medical News Today
Date Published: 
November 12, 2010
Abstract: 

A collaborative effort between researchers at the Salk Institute for Biological Studies and the University of California, San Diego, successfully used human induced pluripotent stem (iPS) cells derived from patients with Rett syndrome to replicate autism in the lab and study the molecular pathogenesis of the disease.

Testing Autism Drugs in Human Brain Cells

Source: 
MIT Technology Review
Date Published: 
November 12, 2010
Abstract: 

A team from the University of California, San Diego, and the Salk Institute for Biological Studies devised a way to study brain cells from patients with autism, and found a way reverse cellular abnormalities in neurons that have been associated with autism, specifically Rett Syndrome.

A Model for Neural Development and Treatment of Rett Syndrome Using Human Induced Pluripotent Stem Cells

Source: 
Cell, Marchetto et al
Date Published: 
November 2010
Year Published: 
2010

Autism spectrum disorders (ASD) are complex neurodevelopmental diseases in which different combinations of genetic mutations may contribute to the phenotype. Using Rett syndrome (RTT) as an ASD genetic model, we recapitulate early stages of a human neurodevelopmental disease, using induced pluripotent stem cells (iPSCs) from RTT patients' fibroblasts, which essentially creates a "disease in a dish". The data uncovered early alterations in developing human RTT neurons and suggest evidence of an unexplored developmental window, before disease onset, in RTT syndrome where potential therapies could be successfully employed. Our model represents a promising cellular tool for drug screening, diagnosis and personalized treatment.

Neurogenetics Research Sheds Light on the Causes of Neurological Disease

Source: 
Science Daily
Date Published: 
October 21, 2010
Abstract: 

The last two decades have seen tremendous progress in understanding the genetic basis of human brain disorders. Research developments in this area have revealed fundamental insights into the genes and molecular pathways that underlie neurological and psychiatric diseases. In a new series of review articles, experts in the field discuss exciting recent advances in neurogenetics research and the potential implications for the treatment of these devastating disorders.

An Epidemic of Fear: How Panicked Parents Skipping Shots Endangers Us All

Source: 
Wired Magazine
Date Published: 
October 19, 2009
Abstract: 

Paul Offit, award-winning 58-year-old scientist, is hated for his opinion on vaccination. He boldly states — in speeches, in journal articles, and in his 2008 book Autism’s False Prophets — that vaccines do not cause autism or autoimmune disease or any of the other chronic conditions that have been blamed on them. He supports this assertion with meticulous evidence. And he calls to account those who promote bogus treatments for autism — treatments that he says not only don’t work but often cause harm.

Scientists One Step Closer to Diagnosing Autism with MRI

Source: 
Sify News
Date Published: 
October 13, 2010
Abstract: 

Researchers at the University of Utah (U of U) are one step closer to diagnosing autism using MRI, an advance that eventually could help health care providers identify the problem much earlier in children and lead to improved treatment and outcomes for those with the disorder.

Preventing Life Threatening Breathing Disorder of Rett Syndrome

Source: 
Medical News Today
Date Published: 
October 5, 2010
Abstract: 

A group of researchers at the University of Bristol have sequestered the potentially fatal breath holding episodes associated with the autistic-spectrum disorder Rett syndrome. Using a unique combination of drugs, they have discovered that the area of the brain that allows breathing to persist throughout life without interruption has reduced levels of a transmitter substance called aminobutyric acid.

Less Pain for Learning Gain

Source: 
Medical News Today
Date Published: 
September 28, 2010
Abstract: 

Now research from Northwestern University suggests a new way of training that could reduce by at least half the effort previously thought necessary to make learning gains. They suggest combining periods of practice may alone be too brief to cause learning with periods of mere exposure to perceptual stimuli.

Hormone Oxytocin Improves Social Cognition but Only in Less Socially Proficient Individuals

Source: 
Science Daily
Date Published: 
September 21, 2010
Abstract: 

Researchers at Mount Sinai School of Medicine have found that the naturally-occurring hormone oxytocin selectively improves social cognitive abilities for less socially proficient individuals, but has little effect on those who are more socially proficient. While more research is required, these results highlight the potential oxytocin holds for treating social deficits in people with disorders marked by deficits in social functioning like autism.

Discovery of Key Pathway Interaction May Lead to Therapies that Aid Brain Growth and Repair

Source: 
Science Daily
Date Published: 
September 16, 2010
Abstract: 

Researchers at the Center for Neuroscience Research at Children's National Medical Center have discovered that the two major types of signaling pathways activated during brain cell development. This knowledge may help scientists design new ways to induce the brain to repair itself when these signals are interrupted, and indicate a need for further research to determine whether disruptions of these pathways in early brain development could lead to common neurodevelopmental disorders such as epilepsy, cerebral palsy, autism, Down syndrome, ADHD, and intellectual disabilities.