Age Alters Patterns of Chemical Tags on Sperm DNA

Published August 18, 2014 in Simons Foundation Autism Research Initiative

The configuration of methyl tags that modify DNA in sperm change as men get older, according to a study published PLOS Genetics. These alterations may help explain why children of older fathers are at increased risk for neuropsychiatric disorders such as autism. Researchers at the University of Utah collected sperm from 17 men, once in the 1990s and again in 2008. They found that the distribution of methyl tags, a particular kind of DNA modification, shows relatively consistent changes over time in the sperm. However, the study does not necessarily prove that these altered patterns survive past fertilization or influence the risk of disorders such as autism.

http://sfari.org/news-and-opinion/news/2014/age-alters-patterns-of-chemical-tags-on-sperm-dna

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