A Higher Mutational Burden in Females Supports a “Female Protective Model” in Neurodevelopmental Disorders

Source: 
American Journal of Human Genetics
Date Published: 
February 27, 2014
Abstract: 

Researchers have more clues as to why more boys than girls are diagnosed with Autism Spectrum Disorder. A new study in the American Journal of Human Genetics suggests that for boys, it takes less of a genetic hit to cause autism than it does for girls. The study continues to say that when it does appear in girls, it is due to a much more severe genetic hit, usually resulting in much more severe autism symptoms.