Modeling an Autism Risk Factor in Mice Leads to Permanent Immune Dysregulation

Proceedings of the National Academy of Sciences
Date Published: 
July 31, 2012

"Increasing evidence highlights a role for the immune system in the pathogenesis of autism spectrum disorder (ASD), as immune dysregulation is observed in the brain, periphery, and gastrointestinal tract of ASD individuals. Furthermore, maternal infection (maternal immune activation, MIA) is a risk factor for ASD. Modeling this risk factor in mice yields offspring with the cardinal behavioral and neuropathological symptoms of human ASD."