Negative Allosteric Modulation of the mGluR5 Receptor Reduces Repetitive Behaviors and Rescues Social Deficits in Mouse Models of Autism

Published April 25, 2012 in Science Translational Medicine

Using a mouse model with behaviors relevant to the three diagnostic behavioral symptoms of autism, researchers used a genetic approach to reduce repetitive behaviors and partially reverse the striking lack of sociability in these mice.

http://www.ncbi.nlm.nih.gov/pubmed/?term=Negative+allosteric+modulation+of+the+mGluR5+receptor+reduces+repetitive+behaviors+and+rescues+social+deficits+in+mouse+models+of+autism

Filed under: , , , , ,