Research by Topic: Gastroenterology

Maternal Metabolic Conditions and Risk for Autism and other Neurodevelopmental Disorders

Published May 8, 2015 in Pediatrics

Maternal metabolic conditions may be broadly associated with neurodevelopmental problems in children. With obesity rising steadily, these results appear to raise serious public health concerns.

http://www.ncbi.nlm.nih.gov/pubmed/22492772

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Gut Microbes Linked to Autismlike Symptoms in Mice

Published December 5, 2013 in Science Magazine

More information has come about about the gut microbes study in Cell. “I’d want to know more about the mechanism by which the bacteria altered behavior in the mice before beginning to translate the findings to humans” says Emanuel DiCicco-Bloom, a neuroscientist at Rutgers University and member of the ASF Scientific Advisory Board.

http://news.sciencemag.org/biology/2013/12/gut-microbes-linked-autismlike-symptoms-mice

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Bacterium Can Reverse Autism-Like Behaviour in Mice

Published December 5, 2013 in Cell

Caltech researchers gave probiotics to mice that had been bred to have autism-like symptoms and found promising results. After being given the probiotics, the mice were more communicative and less anxious. The treatment also reduced gastrointestinal problems in the animals that were similar to those that often accompany autism in humans.

http://www.cell.com/retrieve/pii/S0092867413014736

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Gastrointestinal problems in children with autism, developmental delays or typical development

Published November 6, 2013 in Journal of Autism and Developmental Disororders

"To compare gastrointestinal (GI) problems among children with: (1) autism spectrum disorder (ASD), (2) developmental delay (DD) and (3) typical development (TD), GI symptom frequencies were obtained for 960 children from the Childhood Autism Risks from Genetics and Environment (CHARGE) study. We also examined scores on five Aberrant Behavior Checklist (ABC) subscales comparing ASD children […]

http://www.ncbi.nlm.nih.gov/pubmed/?term=24193577

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Gastrointestinal problems in children with autism, developmental delays or typical development

Published November 6, 2013 in Journal of Autism and Developmental Disororders

"To compare gastrointestinal (GI) problems among children with: (1) autism spectrum disorder (ASD), (2) developmental delay (DD) and (3) typical development (TD), GI symptom frequencies were obtained for 960 children from the Childhood Autism Risks from Genetics and Environment (CHARGE) study. We also examined scores on five Aberrant Behavior Checklist (ABC) subscales comparing ASD children […]

http://www.ncbi.nlm.nih.gov/pubmed/?term=24193577

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Study Finds No Link Between ASDs and Celiac Disease

Published September 25, 2013 in JAMA Psychiatry

A new nationwide study conducted in Sweden and published in JAMA Psychiatry found there to be no link between celiac disease and autism spectrum disorders. There was, however, some evidence that people who have been diagnosed with autism are more sensitive to gluten, even though they don’t have celiac disease. The design of the study did not allow for a conclusion that gluten sensitivity caused autism, nor vice versa.

http://archpsyc.jamanetwork.com/article.aspx?articleid=1743008

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Dr. Susan Hyman Discusses GI Problems in Children with Autism for a Guest Blog Post

Published July 30, 2013

Dr. Susan Hyman addressed many important questions about GI problems associated with autism for our guest blog series “Comorbid Conditions with Autism”. In the post, she provided an informed update on current evidence-based research in the area of GI problems and autism.

http://autismsciencefoundation.wordpress.com/2013/07/30/gastrointestinal-symptoms-in-children-with-autism-spectrum-disorders/

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Gluten Sensitivities May Cause GI Problems in Children with Autism

Published June 18, 2013 in PLoS One

A subset of children with autism displays increased immune reactivity to gluten, the mechanism of which appears to be distinct from that in celiac disease. The increased anti-gliadin antibody response and its association with GI symptoms points to a potential mechanism involving immunologic and/or intestinal permeability abnormalities in affected children.

http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0066155

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Increasing the Gut Bacteria In Mice That Lack Them Helps Increase Their Sociability with Familiar Mice

Published May 21, 2013 in Molecular Psychiatry

A new study finds that increasing the gut bacteria populations in mice that lack them helps to increase their sociability. The increase in sociability is mainly limited to familiar mice but the study does show support for the theory of a connection between the gut and autism in certain cases.

http://www.nature.com/mp/journal/vaop/ncurrent/full/mp201365a.html

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Individuals With Autism Have a Unique Gene Expression In Their Gastrointestinal Tissue.

Published March 8, 2013 in PLoS One

This Wake Forest Study compared the gene expression of gastrointestinal tissue in individuals with autism and compared it to individuals with Crohn’s Disease, ulcerative colitis and a control group. The study showed those with autism had a unique gene expression in their gastrointestinal tissue compared to the other groups studied.

http://www.ncbi.nlm.nih.gov/pubmed/23520485

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Anxiety, sensory over-responsivity, and gastrointestinal problems in children with autism spectrum disorders

Published January 1, 2013 in PubMed

Children with autism spectrum disorders (ASD) experience high rates of anxiety, sensory processing problems, and gastrointestinal (GI) problems; however, the associations among these symptoms in children with ASD have not been previously examined. The current study examined bivariate and multivariate relations among anxiety, sensory over-responsivity, and chronic GI problems in a sample of 2,973 children with ASD enrolled in the Autism Treatment Network (ages 2-17 years, 81.6 % male).

http://www.ncbi.nlm.nih.gov/pubmed/22850932

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Anxiety, Sensory Over-responsivity, and Gastrointestinal Problems in Children with Autism Spectrum Disorders

Published January 1, 2013 in Journal of Abnormal Child Psychology

Anxiety, sensory processing problems and gastrointestinal (GI) issues occur frequently in children with ASD. This study examines the relationship between the three and finds that sensory over-responsivity and anxiety are highly associated and linked to GI problems.

http://www.ncbi.nlm.nih.gov/pubmed?term=22850932

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Study Finds No Link Between Autism and Gut Microbes

Published November 5, 2012 in SFARI

Contradicting a popular hypothesis in autism, a new study from Australia has found no connection between autism and bacteria in the gut. For the peer-reviewed article, click here: http://www.ncbi.nlm.nih.gov/pubmed/22997101

http://sfari.org/news-and-opinion/news/study-finds-no-link-between-autism-and-gut-microbes

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Modeling an Autism Risk Factor in Mice Leads to Permanent Immune Dysregulation

Published July 31, 2012 in Proceedings of the National Academy of Sciences

“Increasing evidence highlights a role for the immune system in the pathogenesis of autism spectrum disorder (ASD), as immune dysregulation is observed in the brain, periphery, and gastrointestinal tract of ASD individuals. Furthermore, maternal infection (maternal immune activation, MIA) is a risk factor for ASD. Modeling this risk factor in mice yields offspring with the cardinal behavioral and neuropathological symptoms of human ASD.”

http://www.ncbi.nlm.nih.gov/pubmed/22802640

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Maternal Periconceptional Folic Acid Intake and Risk of Autism Spectrum Disorders and Developmental Delay in the CHARGE (CHildhood Autism Risks from Genetics and Environment) Case-control Study.

Published May 30, 2012 in American Journal of Clinical Nutrition

Maternal periconceptional folic acid intake may reduce ASD risk in those with inefficient folate metabolism

http://ajcn.nutrition.org/content/96/1/80.short

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Gastrointestinal Problems In Autistic Children May Be Due To Gut Bacteria

Published January 11, 2012 in Medical News Today

The underlying reason autism is often associated with gastrointestinal problems is an unknown, but new results to be published in the online journal mBio on January 10 reveal that the guts of autistic children differ from other children in at least one important way: many children with autism harbor a type of bacteria in their guts that non-autistic children do not.

Gastrointestinal Problems In Autistic Children May Be Due To Gut Bacteria

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ASF-funded study: JADD Challenging behaviors frequent in autistic children with and without GI problems; therefore behaviors are unlikely to predict GI problems in children with ASDMaenner et al.

Published October 25, 2011 in Journal of Autism and Developmental Disorders

Association Between Behavioral Features and Gastrointestinal Problems Among Children with Autism Spectrum DisorderMatthew J. Maenner • Carrie L. Arneson • Susan E. Levy • Russell S. Kirby • Joyce S. Nicholas • Maureen S. DurkinJournal of Autism and Developmental Disorders | DOI 10.1007/s10803-011-1379-6 Copyright: Springer Science+Business Media, LLC 2011 Abstract : Recent reports suggest certain […]

http://www.springerlink.com/content/b23217521067w850/

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Association Between Behavioral Features and Gastrointestinal Problems Among Children with Autism Spectrum Disorder

Published October 25, 2011 in Journal of Autism and Developmental Disorders - Maenner, M.J. et al.

Recent reports suggest certain behaviors among children with autism spectrum disorders (ASD) may indicate underlying gastro-intestinal (GI) problems, and that the presence of these behaviors may help alert primary care providers to the need to evaluate a child with ASD for GI problems. The purpose of this population-based study of 487 children with ASD, including […]

http://www.springerlink.com/content/b23217521067w850/

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Children With Autism And Gastrointestinal Symptoms Have Altered Digestive Genes

Published September 11, 2011 in Medical News Today

Researchers at the Center for Infection and Immunity (CII) at Columbia University’s Mailman School of Public Health and at the Harvard Medical School report that children with autism and gastrointestinal disturbances have altered expression of genes involved in digestion. These variations may contribute to changes in the types of bacteria in their intestines.

http://www.medicalnewstoday.com/releases/234576.php

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Minocycline Promising in Fragile X Syndrome

Published September 7, 2010 in Medscape Today

Parents of children with fragile X syndrome report that minocycline led to positive improvements in language, attention levels and behavior. They also report experiencing adverse side effects such as mild gastrointestinal issues and some increased irritability.

http://www.medscape.com/viewarticle/728141?src=emailthis

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Popular Autism Diet Does Not Demonstrate Behavioral Improvement

Published May 20, 2010 in Science Daily

A popular belief that specific dietary changes can improve the symptoms of children with autism was not supported by a tightly controlled University of Rochester study, which found that eliminating gluten and casein from the diets of children with autism had no impact on their behavior, sleep or bowel patterns.

http://www.sciencedaily.com/releases/2010/05/100519143401.htm

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GI Problems and Autism Link? Experts Say No

Published April 16, 2010 in ABC News

British Medical Journal examined the continued belief by many of a possible connection between the developmental disorder and the chronic inflammatory bowel disease, that was first dubbed “autistic enterocolitis” by British physician Dr. Andrew Wakefield. But beyond Wakefield’s account, the evidence of any connection between bowel disease and autism is slim, the editorial stated.

http://abcnews.go.com/Health/Autism/stomach-pains-autism/story?id=10388309&page=1

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Retraction-IIleal-Lymphoid-Nodular Hyperplasia Non-Specific Colitis, and Pervasive Developmental Disorder in Children

Published February 1, 2010 in Lancet

Dr. Andrew Wakefield's study, in which he investigated a consecutive series of children with chronic enterocolitis and regressive developmental disorder and found associated gastrointestinal disease and developmental regression in a group of previously normal children, which was generally associated in time with possible environmental triggers is retracted.

[http://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2897%2911096-0/abstract

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Incidence of Gastrointestinal Symptoms in Children With Autism: A Population-Based

Published August 1, 2009 in Pediatrics, Ibrahim, Voigt, Katusic, Weaver, and Barbaresi

The Mayo Clinic study finds that autistic kids in the study were more likely than their nonautistic counterparts to be picky eaters or constipated. But the researchers did not find a significant difference between the two groups when it came to diarrhea, abdominal discomfort, bloating, reflux or vomiting. According to Pediatrics, "as constipation and feeding […]

http://pediatrics.aappublications.org/content/124/2/680.full.pdf

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Lack of Association between Measles Virus Vaccine and Autism with Enteropathy: A Case-Control Study

Published December 31, 1969 in PLOS ONE, Hornig, Briese, et al

This study provides strong evidence against association of autism with persistent MV RNA in the GI tract or MMR exposure. Autism with GI disturbances is associated with elevated rates of regression in language or other skills and may represent an endophenotype distinct from other ASD.

http://www.plosone.org/article/info:doi/10.1371/journal.pone.0003140

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