Research by Topic: Hormones

Melatonin for Sleep in Children with Autism: A Controlled Trial Examining Dose, Tolerability, and Outcomes

Published August 8, 2015 in J Autism Dev Disord

Supplemental melatonin has shown promise in treating sleep onset insomnia in children with autism spectrum disorders (ASD).

http://www.ncbi.nlm.nih.gov/pubmed/

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Design and Subject Characteristics in The Federally-Funded Citalopram Trial in Children with Pervasive Developmental Disorders

Published March 8, 2015 in J Autism Dev Disord

This study conducted a randomized trial with citalopram (an anti-depressant drug) in children with Pervasive developmental disorders (PDDs).

http://www.ncbi.nlm.nih.gov/pubmed/

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Maternal Prenatal Weight Gain and Autism Spectrum Disorders

Published October 28, 2013 in Pediatrics

New research from the University of Utah and published in the journal Pediatrics has uncovered an association between autism spectrum disorders and a small increase in the amount of weight a mother gains during pregnancy. These findings suggest that weight gain during pregnancy is not the cause of ASD but rather may reflect an underlying process that it shares with autism spectrum disorders, such as abnormal hormone levels or inflammation.

http://pediatrics.aappublications.org/content/early/2013/10/23/peds.2013-1188.abstract

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Autism Four Times Likelier When Mother’s Thyroid is Weakened

Published August 13, 2013 in Annals of Neurology

A study from the Houston Methodist Neurological Institute and Erasmus Medical Centre discovered that mothers who do not produce enough of a thyroid hormone, thyroxine, are nearly four times more likely to have a child with autism. In the past, this hormone has been shown to be important in the migration of fetal brain cells during embryo development.

http://www.methodisthealth.com/methodist.cfm?xyzpdqabc=0&id=495&action=detail&ref=1078

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Elevated Repetitive Behaviors are Associated with Lower Diurnal Salivary Cortisol Levels in Autism Spectrum Disorder

Published March 1, 2013 in Biological Psychiatry

This pilot study examined the relationship between repetitive behaviors (RBs) and cortisol, a hormone that is released in response to stress, in individuals with ASD. Multiple salivary cortisol samples were taken over three days for 21 children with ASD with high and low levels of RBs. Children in both groups showed the same pattern of cortisol change throughout the day, but the overall cortisol levels in the high RB group were significantly lower, suggesting RBs may work to soothe and decrease stress.

http://www.ncbi.nlm.nih.gov/pubmed/23466586

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Sex Differences in Autism Spectrum Disorders

Published February 13, 2013 in Current Opinion in Neurology

A review of current research shows that ASD affects females less frequently than males and suggests this difference may be due to several sex-differential genetic and hormonal factors.

http://www.ncbi.nlm.nih.gov/pubmed/23406909

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Prenatal Versus Postnatal Sex Steroid Hormone Effects on Autistic Traits in Children at 18 to 24 Months of Age

Published December 11, 2012 in Molecular Autism

Cambridge researchers are investigating the link between pre- and postnatal hormone levels and autistic traits later in life.

http://www.molecularautism.com/content/pdf/2040-2392-3-17.pdf

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Vanderbilt University Researchers Examine Oxytocin and Serotonin Systems as Biomarkers for Autism

Published May 26, 2012 in http://www.ncbi.nlm.nih.gov/pubmed/22721594.1

Vanderbilt University researchers examine oxytocin and serotonin systems as biomarkers for autism spectrum disorders.

http://www.ncbi.nlm.nih.gov/pubmed/22721594.1

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Researchers Reveal First Autism Candidate Gene That Demonstrates Sensitivity to Sex Hormones

Published March 1, 2011 in Journal of Molecular Psychiatry, Hu et al.

George Washington University researchers have found that male and female sex hormones regulate expression of an important gene in neuronal cell culture through a mechanism that could explain not only higher levels of testosterone observed in some individuals with autism, but also why males have a higher incidence of autism than females. The gene, RORA, […]

http://www.sciencedaily.com/releases/2011/02/110216185402.htm

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Researchers Reveal First Autism Candidate Gene That Demonstrates Sensitivity to Sex Hormones

Published February 17, 2011 in Science Daily

George Washington University researcher, Dr. Valerie Hu, Professor of Biochemistry and Molecular Biology, and her team at the School of Medicine and Health Sciences, have found that male and female sex hormones regulate expression of an important gene in neuronal cell culture through a mechanism that could explain not only higher levels of testosterone observed in some individuals with autism, but also why males have a higher incidence of autism than females.

http://www.sciencedaily.com/releases/2011/02/110216185402.htm

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Oxytocin Improves Social Behavior of Patients, French Study Finds

Published February 17, 2010 in Science Daily

Autism is a disease characterized by difficulties in communicating effectively with other people and developing social relationships. A team led by Angela Sirigu at the Centre de Neuroscience Cognitive (CNRS) has shown that the inhalation of oxytocin, a hormone known to promote mother-infant bonds and social relationships, significantly improved the abilities of autistic patients to interact with other individuals.

http://www.sciencedaily.com/releases/2010/02/100216221350.htm

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