- About ASF
- What is Autism?
- How Common is Autism?
- Early Signs of Autism
- Autism Diagnosis
- Following a Diagnosis
- Treatment Options
- Beware of Non Evidence-Based Treatments
- Autism and Vaccines
- Autism Science
- Autism Research Strategic Plan
- Research by Topic
- Research by Year
- Interviews with Scientists
- Science Journals
- Autism In The News
- Recommended Reading
- Participate in Research
- NIH ACE Grants
- NIMH Resources
- Autism Research Glossary
- Quick Facts About Autism
- What We Fund
- Funding Calendar
- ASF Funded Research
- Research Results
- Grant Outcomes Reports
- Apply for a Research Grant
- Apply for a Research Mini-Grant
- Apply for an Undergraduate Summer Research Grant
- Apply for IMFAR Travel Grant
- Get Involved
- Day of Learning & Evening of Celebration
- Contact Us
ASD & Tuberous Sclerosis Complex
Aug 8 2012
Dec 31 2014
Location:Laboratories of Cognitive Neuroscience, Division of Developmental Medicine, Boston Children's Hospital
Together with the University of California, Los Angeles, we are investigating the development of Tuberous Sclerosis Complex (TSC), a genetic disorder. Up to 60% of children with TSC develop autism, but often the diagnosis is not made until much later in childhood. Our aim is to identify pathways to earlier identification of autism spectrum disorders, which leads to earlier interventions and, hopefully, better behavioral outcomes.
To properly investigate the development of children with TSC we are also recruiting typically developing children to provide comparison data.
Eligibility for Study Participation:
Typically developing infants 3 to 12 months of age who
have no history of pre or postnatal difficulties
Infants with TSC from 3 to 24 months of age
If you decide to participate in this study, which has a longitudinal design, it will involve multiple visits to the LCN at regular time points during your baby's first 3 years of life. Each visit will last about 2 1/2 hours and will be scheduled at a time that is convenient for you and your child. Parents will be with their child at all times. There is also an optional sleeping MRI portion of study.
Tuberous Sclerosis Complex (TSC) is a genetic disorder caused by mutations in either the TSC1 or TSC2 genes. TSC is characterized by the widespread growth of benign, tumor-like nodules called hamartomas in multiple organ systems, including the brain. It is strongly associated with cognitive impairment, behavioral disturbances, and autism spectrum disorders (ASD), and these neurodevelopmental disorders can cause significant disability from early infancy through adulthood.Cognitive impairment has been reported in 44-80% of individuals with TSC, ranging from learning disabilities to more profound intellectual impairment.
We are using behavioral tests as well as measures of the brain’s electrical response to faces to characterize the development of children with and without TSC and evaluate their risk for autism. We will follow infants from age three months through age three, at which time they will be evaluated for autism concerns. We will then determine if any early abnormalities in behavior and face processing can predict autism in these infants.
Tessa Clarkson; firstname.lastname@example.org
For more information visit: http://childrenshospital.org/cfapps/research/data_admin/Site2205/mainpageS2205P59.html