Animal Models

How Immune Response in Pregnancy May Lead to Brain Disfunction in Offspring

Source: 
Science Daily
Date Published: 
October 14, 2010
Abstract: 

A pregnant woman's immune response to viral infections may induce subtle neurological changes in the unborn child that can lead to an increased risk for neurodevelopmental disorders including schizophrenia and autism.

Preventing Life Threatening Breathing Disorder of Rett Syndrome

Source: 
Medical News Today
Date Published: 
October 5, 2010
Abstract: 

A group of researchers at the University of Bristol have sequestered the potentially fatal breath holding episodes associated with the autistic-spectrum disorder Rett syndrome. Using a unique combination of drugs, they have discovered that the area of the brain that allows breathing to persist throughout life without interruption has reduced levels of a transmitter substance called aminobutyric acid.

Interneurons Are Not All Created Equally, Some Classes of Interneurons May Underlie Distinct Brain Disorders

Source: 
Science Daily
Date Published: 
September 8, 2010
Abstract: 

Study contests the idea that interneurons have broad, non-specific functions and argues that interneurons have well-defined properties and roles. If classified by their unique features, they may be utilized for specific forms of inhibition.

Scientists Identify New Drug Strategy Against Fragile X Syndrome

Source: 
Science Daily
Date Published: 
August 10, 2010
Abstract: 

Researchers at Emory University School of Medicine have identified a potential new strategy for treating fragile X syndrome -- the most common inherited cause of intellectual disability. The researchers have found that a class of drugs called phosphoinositide-3 (PI3) kinase inhibitors can correct defects in the anatomy of neurons seen in a mouse model of fragile X syndrome.

Immune System Troubles Could Spark Behavior Woes

Source: 
Bloomberg Businessweek
Date Published: 
May 27, 2010
Abstract: 

In the first scientific illustration of exactly how some psychiatric illnesses might be linked to an immune system gone awry, researchers report they cured mice of an obsessive-compulsive condition known as "hair-pulling disorder" by tweaking the rodents' immune systems.

Mt. Sinai Identifies First Drug to Demonstrate Therapeutic Effect in a Type of Autism

Source: 
EurekAlert
Date Published: 
May 20, 2010
Abstract: 

Researchers from Mount Sinai School of Medicine have identified a drug that improves communication between nerve cells in a mouse model of Phelan-McDermid Syndrome (PMS). Behavioral symptoms of PMS fall under the autism spectrum disorder category.

Autism and Schizophrenia: Research Builds on Genetic Link

Source: 
Medical News Today
Date Published: 
February 24, 2010
Abstract: 

A genetic link between schizophrenia and autism is enabling researchers to study the effectiveness of drugs used to treat both illnesses. Dr. Steve Clapcote from the University of Leeds's Faculty of Biological Sciences will be analyzing behavior displayed by mice with a genetic mutation linked to schizophrenia and autism and seeing how antipsychotic drugs affect their behavioral abnormalities.

Gene Mutation is Linked to Autism-Like Symptoms in Mice, Reseachers Find

Source: 
Science Daily
Date Published: 
February 24, 2010
Abstract: 

When a gene implicated in human autism is disabled in mice, the rodents show learning problems and obsessive, repetitive behaviors, researchers at UT Southwestern Medical Center have found. The researchers also report that a drug affecting a specific type of nerve function reduced the obsessive behavior in the animals, suggesting a potential way to treat repetitive behaviors in humans

Link Between Genetic Defect And Brain Changes In Schizophrenia Demonstrated

Source: 
Science Daily
Date Published: 
October 17, 2009
Abstract: 

Researchers at the University of North Carolina at Chapel Hill School of Medicine have found that the 22q11 gene deletion -- a mutation that confers the highest known genetic risk for schizophrenia -- is associated with changes in the development of the brain that ultimately affect how its circuit elements are assembled.

The researchers would now like to figure out how these alterations in the circuitry of the brain affect the behavior of the mouse. They also hope that understanding the "mis-wiring" of the brain in a genetic animal model of schizophrenia would help them understand the causes of the disease in the general population

Seaside Therapeutics Secures $30 Million Financing

Source: 
Reuters
Date Published: 
September 17, 2009
Abstract: 

Seaside Therapeutics LLC today announced that it has secured $30 million in financing from a private, family investment firm which is committed to advancing research in the field of autism and Fragile X Syndrome.