Autism Research

De Novo Mutations in Human Genetic Disease

Source: 
Nature Reviews: Genetics
Date Published: 
July 18, 2012
Abstract: 

The influence of genetic mutations on the burden of any genetic disease can usefully be determined using family-based whole-genome or whole-exome sequencing approaches.

An Incidence Study of Diagnosed Autism-Spectrum Disorders Among Immigrants to the Netherlands

Source: 
Acta Psychiatrica Scandinavia
Date Published: 
Dec 9, 2012
Abstract: 

This study looks at the incidence of autism-spectrum disorder (ASD) in children born to Scandinavian immigrants as well as the incidence of ASD in children born to native Dutch parents.

Live Chat with Dr. Simon Baron-Cohen

Source: 
ASF
Date Published: 
April 5, 2013
Abstract: 

Did you miss the live chat? Read the transcript here.

Global Increases in Both Common and Rare Copy Number Load Associated with Autism

Source: 
Human Molecular Genetics
Date Published: 
March 27, 2013
Abstract: 

Penn State researchers link autism to increased genetic change in "hotspots", regions of the genome that are highly susceptible to mutation.

White House Announces New Brain Research Initiative

Date Published: 
April 2, 2013
Abstract: 

ASF President Alison Singer joined President Obama for the official public announcement of the BRAIN Initiative.

Increasing Exposure to Antibody-Stimulating Proteins and Polysaccharides in Vaccines Is Not Associated with Risk of Autism

Source: 
Journal of Pediatrics
Date Published: 
March 6, 2013
Abstract: 

This CDC study casts further doubt on the link between autism and vaccines. The study found no connection between the number of vaccines received and autism risk.

Autism Risk Across Generations A Population-Based Study of Advancing Grandpaternal and Paternal Age

Source: 
JAMA Psychiatry
Date Published: 
March 20, 2013
Abstract: 

Recently published in JAMA Psychiatry, this study put forth a new autism risk factor: advanced grandpaternal age. Compared to men who had children between 20 and 24, men who fathered a child at 50+ were 1-2 times more likely to have a grandchild with autism. The findings suggest some autism risk factors can accumulate over generations.

A Quantitative Link between Face Discrimination Deficits and Neuronal Selectivity for Faces in Autism

Source: 
NeuroImage: Clinical
Date Published: 
March 15, 2013
Abstract: 

In this fMRI study of adults with ASD, reduced neuronal selectivity for faces was linked to greater behavioral deficits in face recognition.

Tipping the balance of autism risk: potential mechanisms linking pesticides and autism.

Source: 
PubMed
Date Published: 
July 2012
Abstract: 

In animal studies, we encourage more research on gene × environment interactions, as well as experimental exposure to mixtures of compounds. Similarly, epidemiologic studies in humans with exceptionally high exposures can identify which pesticide classes are of greatest concern, and studies focused on gene × environment are needed to determine if there are susceptible subpopulations at greater risk from pesticide exposures.

Maternal periconceptional folic acid intake and risk of autism spectrum disorders and developmental delay in the CHARGE (CHildhood Autism Risks from Genetics and Environment) case-control study.

Source: 
PubMed
Date Published: 
July 2012
Abstract: 

Folic acid may reduce ASD risk in those with inefficient folate metabolism. The replication of these findings and investigations of mechanisms involved are warranted.