Autism Research

CNVs: harbingers of a rare variant revolution in psychiatric genetics.

Source: 
PubMed
Date Published: 
March 16, 2012
Abstract: 

CNV studies reflects the nature of rare alleles in general and will serve as a guide as we move forward into a new era of whole-genome sequencing.

Migration and autism spectrum disorder: population-based study.

Source: 
PubMed
Date Published: 
August 2012
Abstract: 

Children of migrant parents may be at greater risk of low-functioning autism spectrum disorder, but lower risk of high-functioning autism spectrum disorder.

A Research Strategy to Discover the Environmental Causes of Autism and Neurodevelopmental Disabilities

Source: 
Environmental Health Perspectives
Date Published: 
July 2, 2012
Abstract: 

It is intended to focus research in environmental causation of NDDs on a short list of chemicals where concentrated study has high potential to generate actionable findings in the near future. Its ultimate purpose is to catalyze new evidence-based programs for prevention of disease in America’s children.

Maternal metabolic conditions and risk for autism and other neurodevelopmental disorders.

Source: 
PubMed
Date Published: 
May 2012
Abstract: 

Maternal MCs may be broadly associated with neurodevelopmental problems in children. With obesity rising steadily, these results appear to raise serious public health concerns.

Rate of de novo mutations and the importance of father's age to disease risk.

Source: 
PubMed
Date Published: 
August 23, 2012
Abstract: 

These observations shed light on the importance of the father's age on the risk of diseases such as schizophrenia and autism.

De Novo Gene Disruptions in Children on the Autistic Spectrum.

Source: 
Neuron
Date Published: 
April 26, 2012
Abstract: 

FMRP-associated genes are under greater purifying selection than the remainder of genes and suggest they are especially dosage-sensitive targets of cognitive disorders.

A novel approach of homozygous haplotype sharing identifies candidate genes in autism spectrum disorder.

Source: 
PubMed
Date Published: 
April 2012
Abstract: 

Findings highlight the applicability of HH mapping in complex disorders such as ASD and offer an alternative approach to the analysis of genome-wide association data.

Genetic Architecture in Autism Spectrum Disorder.

Source: 
Current Opinion in Genetics and Development
Date Published: 
June 2012
Abstract: 

Biological pathways revealed by the deeper list of ASD genes should narrow the targets for therapeutic intervention.

The genetic variability and commonality of neurodevelopmental disease.

Source: 
PubMed
Date Published: 
May 15, 2010
Abstract: 

Recent genetic studies have revealed some common themes: considerable locus heterogeneity, variable expressivity for the same mutation, and a role for multiple disruptive events in the same individual affecting genes in common pathways.

A common X-linked inborn error of carnitine biosynthesis may be a risk factor for nondysmorphic autism.

Source: 
PubMed
Date Published: 
May 22, 2012
Abstract: 

Data suggest that dysregulation of carnitine metabolism may be important in nondysmorphic autism; that abnormalities of carnitine intake, loss, transport, or synthesis may be important in a larger fraction of nondysmorphic autism cases; and that the carnitine pathway may provide a novel target for therapy or prevention of autism.