Behavior

Reversal of Autism-Like Behaviors and Metabolism in Adult Mice with Single-Dose Antipurinergic Therapy

Source: 
Translational Psychiatry
Date Published: 
June 17, 2014
Abstract: 

Researchers at UC San Diego have discovered that suramin, a drug that was originally developed to treat African sleeping sickness, reverses autism-like social behaviors in mice. This study proposes that the social difficulties and metabolism issues found in individuals with ASD could be improved with the use of suramin — even in adults. While suramin has not been tested in humans, these findings could direct future research for autism therapies.

Gastrointestinal problems in children with autism, developmental delays or typical development

Source: 
Journal of Autism and Developmental Disororders
Date Published: 
November 6, 2013

"To compare gastrointestinal (GI) problems among children with: (1) autism spectrum disorder (ASD), (2) developmental delay (DD) and (3) typical development (TD), GI symptom frequencies were obtained for 960 children from the Childhood Autism Risks from Genetics and Environment (CHARGE) study. We also examined scores on five Aberrant Behavior Checklist (ABC) subscales comparing ASD children with high versus low frequency GI symptoms. Compared to TD children, those with ASD [aOR 7.92 (4.89-12.85)] and DD [aOR 4.55 (2.51-8.24)] were more likely to have at least one frequent GI symptom. Restricting to ASD children, those with frequent abdominal pain, gaseousness, diarrhea, constipation or pain on stooling scored worse on irritability, social withdrawal, stereotypy, and hyperactivity compared with children having no frequent GI symptoms. Frequent GI problems affect young children with ASD and DD more commonly than those with TD. Maladaptive behaviors correlate with GI problems, suggesting these comorbidities require attention."

Gastrointestinal problems in children with autism, developmental delays or typical development

Source: 
Journal of Autism and Developmental Disororders
Date Published: 
November 6, 2013

"To compare gastrointestinal (GI) problems among children with: (1) autism spectrum disorder (ASD), (2) developmental delay (DD) and (3) typical development (TD), GI symptom frequencies were obtained for 960 children from the Childhood Autism Risks from Genetics and Environment (CHARGE) study. We also examined scores on five Aberrant Behavior Checklist (ABC) subscales comparing ASD children with high versus low frequency GI symptoms. Compared to TD children, those with ASD [aOR 7.92 (4.89-12.85)] and DD [aOR 4.55 (2.51-8.24)] were more likely to have at least one frequent GI symptom. Restricting to ASD children, those with frequent abdominal pain, gaseousness, diarrhea, constipation or pain on stooling scored worse on irritability, social withdrawal, stereotypy, and hyperactivity compared with children having no frequent GI symptoms. Frequent GI problems affect young children with ASD and DD more commonly than those with TD. Maladaptive behaviors correlate with GI problems, suggesting these comorbidities require attention."

Adults with Autism Can't Discern False Emotions

Source: 
Simons Foundation Autism Research Initiative
Date Published: 
January 17, 2014
Abstract: 

Adults with autism usually understand in theory when and why others may feign emotions, but they don’t recognize those expressions in real-life situations, reports a study published in Autism Research. This inability to guess what triggered someone’s subtle expression can lead to social missteps — congratulating instead of consoling a disappointed friend, for example.

Catalog of Symptoms Aims to Unravel Autism Diversity

Source: 
Simons Foundation Autism Research Initiative
Date Published: 
January 8, 2014
Abstract: 

Researchers have standardized labels for nearly 300 traits of autism, drawn from 24 diagnostic tests for the disorder, they reported in Neuroinformatics. They can use these terms to search for certain traits among large catalogs of the genetics and symptoms of people with autism. The new study aims to build a defined list, or ontology, of the traits these tests assess. The goal is to allow researchers to compare results across different diagnostic tests and identify the same features, regardless of the test used. The new tool can also help classify individuals with autism into subgroups, which may reflect different causes of the disorder.

Children with Autism Benefit from Peer Solicitation

Source: 
Journal of Child Psychology and Psychiatry.
Date Published: 
December 12, 2013
Abstract: 

Peer solicitation – a child inviting another to play – can improve reciprocal social interaction among children with autism, according to a recent Vanderbilt University study. While the children with autism in the study initiated and engaged in less play overall than typically developing children, the researchers found that other children can facilitate and increase interactions by simple requests. These findings highlight the pivotal role that peers have in social interaction, noting that it only takes a single child to prompt other children – with or without autism – to interact.

EASI Foundation Symposium: "Treating Dangerous Behaviors in the Developmentally Disabled"

Oct 2 2013 12:02 pm
America/New York
Start Date: 
December 4, 2013
Location: 
The Philadelphia Free Library, 1901 Vine Street, Philadelphia
A study published earlier this year in the journal Research in Autism Spectrum Disorders found aggressive behavior in more than half of autistic children and adolescents. These behaviors are notoriously difficult to treat; a 2005 British study confirmed that aggressive and self-injurious behaviors don’t improve as children age—rather, they worsen in intensity and frequency over time. 
 
This symposium will address the treatment of dangerous behaviors, including:
•What types of behaviors are more likely to respond to medical treatments than behavior strategies
•Which medications have been most successful treating these behaviors
•What can be done if medications fail, including ECT and neurobehavioral units
 
An extensive question and answer session will follow the presentations. A light dinner will be served during the break.
Register online at easifoundation.eventbrite.com. Registrations will be accepted at the door if space permits.

Study of Nonverbal Autism Must Go Beyond Words, Experts Say

Source: 
Simons Foundation Autism Research Institute
Date Published: 
September 2, 2013
Abstract: 

About one fourth of people with autism are minimally verbal or nonverbal. Early intervention programs have been helping children develop language skills, but researchers say that seemingly unrelated issues such as motor skills and joint attention may hold the key to communication development.

Neural Mechanisms of Improvements in Social Motivation After Pivotal Response Treatment: Two Case Studies

Source: 
J Autism Dev Disord
Date Published: 
January 2013
Year Published: 
2013
Abstract: 

In this study, functional magnetic resonance imaging was used to identify the neural correlates of successful response to Pivotal response treatment (PRT) in two young children with Autism Spectrum Disorder (ASD).

A Systematic Review of Vocational Interventions for Young Adults with Autism Spectrum Disorders

Source: 
Pediatrics
Date Published: 
September, 2012
Year Published: 
2012
Abstract: 

This study systematically reviewed evidence regarding vocational interventions for individuals with Autism Spectrum Disorder (ASD) between the ages of 13 and 30 years.