Brain Development

Functional magnetic resonance imaging of autism spectrum disorders

Source: 
Dialogues in Clinical Neuroscience
Date Published: 
December 10, 2012
Abstract: 

Dr. Gabriel Dichter presents a new review of fMRI research in ASD, noting common themes of atypical activation and functional connectivity in the brain.

FMRP Targets Distinct mRNA Sequence Elements to Regulate Protein Expression

Source: 
Nature
Date Published: 
December 12, 2012
Abstract: 

Researchers link Fragile X syndrome protein to 93 genes that have been implicated in ASD. Lead investigator says the findings may lead to more detailed genetic tests.

Scientists Home in on Autism Candidate Gene’s Role in Brain

Source: 
SFARI
Date Published: 
November 26, 2012
Abstract: 

Four new studies of neuroligin-1 (NLGN1), a gene linked to autism, unravel its complex role in regulating synapses, the connections between neurons.

Neural Mechanisms of Improvements in Social Motivation After Pivotal Response Treatment: Two Case Studies

Source: 
Journal of Autism and Developmental Disorders
Date Published: 
October 27, 2012
Abstract: 

Researchers find increased activation to social stimuli in brain regions involved in social perception in two children with ASD after pivotal response treatment (PRT).

Early Behavioral Intervention is Associated with Normalized Brain Activity in Young Children with Autism

Source: 
Journal of the American Academy of Child & Adolescent Psychiatry
Date Published: 
August 31, 2012
Abstract: 

This randomized trial associated ESDM with normalized brain activity and behavioral improvements in young children with ASD.

Postmortem Brain Analysis Points to Autism Candidate Genes

Source: 
SFARI
Date Published: 
October 16, 2012
Abstract: 

Unpublished data presented at the 2012 Society for Neuroscience annual meeting show at least 30 genes show altered expression in brain tissue of people with autism. The ongoing study aims to include more samples than previous postmortem studies, and includes samples lost in Harvard’s freezer malfunction.

Unreliable Evoked Responses in Autism

Source: 
Neuron
Date Published: 
September 20, 2012
Abstract: 

This imaging study led by Carnegie Mellon researchers suggests adults with autism have unreliable neural responses when presented with basic sensory information.

University says findings could bring us closer to understanding the connection between brain and behavior in autism. See the press release here: http://www.cmu.edu/news/stories/archives/2012/september/sept19_autisticn...

Announcing the Autism Brain Imaging Data Exchange, a Database of Brain Scans from Over 15 Medical and Research Institutions Worldwide

Source: 
Enhanced Online News
Date Published: 
September 24, 2012
Abstract: 

Researchers officially announce the creation of the Autism Brain Imaging Data Exchange, a database of previously collected brain scans from over 15 medical and research institutions worldwide. The founders aim to advance scientific understanding of ASD through this data sharing initiative.

Shared Synaptic Pathophysiology in Syndromic and Nonsyndromic Rodent Models of Autism

Source: 
Science
Date Published: 
September 13, 2012
Abstract: 

A new study finds that faulty neuronal circuits in autistic brains can be corrected even after the “critical window” of brain development.