Oxytocin

Oxytocin enhances brain function in children with autism

Source: 
Proceedings of the National Academy of Sciences
Date Published: 
December 24, 2013

"Following intranasal administration of oxytocin (OT), we measured, via functional MRI, changes in brain activity during judgments of socially (Eyes) and nonsocially (Vehicles) meaningful pictures in 17 children with high-functioning autism spectrum disorder (ASD). OT increased activity in the striatum, the middle frontal gyrus, the medial prefrontal cortex, the right orbitofrontal cortex, and the left superior temporal sulcus. In the striatum, nucleus accumbens, left posterior superior temporal sulcus, and left premotor cortex, OT increased activity during social judgments and decreased activity during nonsocial judgments. Changes in salivary OT concentrations from baseline to 30 min postadministration were positively associated with increased activity in the right amygdala and orbitofrontal cortex during social vs. nonsocial judgments. OT may thus selectively have an impact on salience and hedonic evaluations of socially meaningful stimuli in children with ASD, and thereby facilitate social attunement. These findings further the development of a neurophysiological systems-level understanding of mechanisms by which OT may enhance social functioning in children with ASD."

Oxytocin and Serotonin May Not be Rewarding Social Interactions in Autistic Brain

Source: 
Nature
Date Published: 
September 11, 2013
Abstract: 

In the brain, oxytocin and serotonin work together to make social interactions pleasurable, rewarding, and worth repeating. A new study in the journal Nature shows that in individuals with autism, these rewarding functions may not be occurring properly, making social interaction uncomfortable.

An article in TIME on this study can be found here

New Study Deciphers Potential Roles of Oxytocin in Brain Function

Source: 
Nature
Date Published: 
August 4, 2013
Abstract: 

An NYU study explored the role of oxytocin in the brain's ability to filter wanted stimuli from unwanted stimuli. The researchers suggest that the neurohormone, oxytocin, is not only used to reduce unwanted background noise but also plays a key function in strengthening desired signals.

Oxytocin-Looking Beyond the Love Drug

Source: 
Wall Street Journal
Date Published: 
August 10, 2012
Abstract: 

Important work from ASF SAB Member Kevin Pelphrey of the Yale Child Study Center.