Risk Factors

Sporadic Autism Exomes Reveal a Highly Interconnected Protein Network of De Novo Mutations

Source: 
Nature
Date Published: 
April 4, 2012
Abstract: 

Researchers demonstrate that de-novo point mutations are overwhelmingly paternal in origin (4:1 bias) and positively correlated with paternal age, consistent with the modest increased risk for children of older fathers to develop ASD.

Rate of De Novo Mutations and the Importance of Father’s Age to Disease Risk

Source: 
Nature
Date Published: 
August 23, 2012
Abstract: 

The diversity in mutation rate of SNP's is dominated by the age of the father at conception of the child. The effect is an increase of about two mutations per year.

An Incidence Study of Diagnosed Autism-Spectrum Disorders Among Immigrants to the Netherlands

Source: 
Acta Psychiatrica Scandinavia
Date Published: 
Dec 9, 2012
Abstract: 

This study looks at the incidence of autism-spectrum disorder (ASD) in children born to Scandinavian immigrants as well as the incidence of ASD in children born to native Dutch parents.

Association of Maternal Exposure to Childhood Abuse With Elevated Risk for Autism in Offspring

Source: 
JAMA Psychiatry
Date Published: 
March 20, 2013
Abstract: 

This study examined the relationship between maternal childhood abuse and autism in children in a large population-based sample. Maternal abuse was significantly associated with increased autism risk even after researchers controlled for perinatal risk factors, including gestational diabetes, smoking during pregnancy, preeclampsia, exposure to intimate partner violence and premature birth.