Toddlers

Blood-based Gene Expression Signatures of Infants and Toddlers with Autism.

Source: 
Journal of the American Academy of Child and Adolescent Psychiatry
Date Published: 
September 2012
Abstract: 

"OBJECTIVE: Autism spectrum disorders (ASDs) are highly heritable neurodevelopmental disorders that onset clinically during the first years of life. ASD risk biomarkers expressed early in life could significantly impact diagnosis and treatment, but no transcriptome-wide biomarker classifiers derived from fresh blood samples from children with autism have yet emerged.

RESULTS: Potential ASD biomarkers were discovered in one-half of the sample and used to build a classifier, with high diagnostic accuracy in the remaining half of the sample."

Toward Brief “Red Flags” for Autism Screening: The Short Autism Spectrum Quotient and the Short Quantitative Checklist for Autism in Toddlers in 1,000 Cases and 3,000 Controls

Source: 
Journal of the American Academy of Child and Adolescent Psychiatry
Date Published: 
February 2012
Abstract: 

Ten items were taken from the Autism Spectrum Quotient (AQ) and the Quantitative Checklist for Autism in Toddlers (Q-CHAT) to develop brief screening tools for ASD. Researchers hope these new measures will help doctors decide whether to refer families for full diagnostic assessments.

Differences in Autism Symptoms Between Minority and Non-Minority Toddlers

Source: 
Journal of Autism and Developmental Disorders
Date Published: 
September 2012
Abstract: 

Researchers discover gross motor, communication and language score differences between minority and non-minority toddlers with ASD. The authors suggest that due to cultural differences, minority parents may not seek intervention services until more significant delays are present. Methods to improve early identification in these groups are discussed.

Portable Intermodal Preferential Looking (IPL): Investigating Language Comprehension in Typically Developing Toddlers and Young Children with Autism.

Source: 
PubMed
Date Published: 
December 14, 2012
Abstract: 

Researchers at UCONN have developed an intermodel preferential looking assessment that relies on the child's attention, rather than verbal or gestural responses, to evaluate language comprehension.

Autism Developmental Delay Begins After 6 Months of Age

Source: 
Psych Central
Date Published: 
October 31, 2012
Abstract: 

A large, prospective study found that children with and without ASD were developmentally similar at 6 months based on clinical tests. Lead author Dr. Rebecca Landa reported, “for those children who went on to develop autism, the earliest signs of atypical development were non-specific to autism, such as general communication or motor delay.”

Early Behavioral Intervention is Associated with Normalized Brain Activity in Young Children with Autism

Source: 
Journal of the American Academy of Child & Adolescent Psychiatry
Date Published: 
August 31, 2012
Abstract: 

This randomized trial associated ESDM with normalized brain activity and behavioral improvements in young children with ASD.

The Development of Referential Communication and Autism Symptomatology in High-Risk Infants

Source: 
Infancy
Date Published: 
October 1, 2012
Abstract: 

This study suggests that non-verbal communication delays in infants with autistic siblings can predict later ASD symptoms.

For a Science Daily article on this paper, click here: http://www.sciencedaily.com/releases/2012/10/121001124802.htm

Effects of a Brief Early Start Denver Model (ESDM)-Based Parent Intervention on Toddlers at Risk for Autism Spectrum Disorders: A Randomized Controlled Trial

Source: 
Journal of the American Academy of Child & Adolescent Psychiatry
Date Published: 
October 2012
Year Published: 
2012
Abstract: 

Contrary to their hypothesis, Sally Rogers and colleagues found that toddlers with ASD in a brief, parent-delivered ESDM program did not make greater gains or show reduced core ASD symptoms compared to autistic toddlers in a community ESDM program. Study strongly suggests number of intervention hours and younger age at initiation are key to maximizing intervention benefits, even for 1 and 2 year olds. Authors say, “the ‘wait and see’ approach to early ASD must be replaced by an ‘act now’ mentality.”

Supplemental Material Blood-Based Gene Expression Signatures of Infants and Toddlers With Autism

Source: 
Journal of the American Academy of Child & Adolescent Psychiatry
Date Published: 
September 2012
Abstract: 

Dr. Eric Courchesne recently published his work he previewed at this year's IMFAR in the "Journal of the American Academy of Child & Adolescent Psychiatry."

The mRNA expression abnormalities reliably observed in peripheral blood mononuclear cells, which are safely and easily assayed in infants, offer the first potential peripheral blood–based, early biomarker panel of risk for autism in infants and toddlers. Future work should verify these biomarkers and evaluate whether they may also serve as indirect indices of deviant molecular neural mechanisms in autism.

Questionnaire Completed by Parents May Help Identify One-Year-Olds at Risk for Autism

Source: 
University of North Carolina School of Medicine
Date Published: 
July 13, 2012
Abstract: 

According to researchers at the University of North Carolina School of Medicine, a new parent evaluation tool may help identify children with ASDs as early as 12 months.