A Multisite Study of the Clinical Diagnosis of Different Autism Spectrum Disorders

Published March 1, 2012 in Archives of General Psychiatry

“OBJECTIVE: To determine whether the relationships between behavioral phenotypes and clinical diagnoses of different autism spectrum disorders vary across 12 university-based sites.CONCLUSION: Clinical distinctions among categorical diagnostic subtypes of autism spectrum disorders were not reliable even across sites with well-documented fidelity using standardized diagnostic instruments. Results support the move from existing subgroupings of autism spectrum disorders to dimensional descriptions of core features of social affect and fixated, repetitive behaviors, together with characteristics such as language level and cognitive function.”

http://www.ncbi.nlm.nih.gov/pubmed/22065253

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