Dysregulation of Estrogen Receptor Beta, Aromatase, and ER Co-Activators in the Middle Frontal Gyrus of Autism Spectrum Disorder Subjects

Published September 9, 2014 in Molecular Autism

In a study conducted at the medical college of Georgia, researchers found a reduction in estrogen receptors in the frontal cortex of brains of boys with ASD. They also found a decrease in the expression of an enzyme that regulates hormones in the brain. The researchers suggest that this may be one of the reasons for the sex difference in ASD, but these findings also point to a potential gene/environment interaction in the disorder. One of the drawback of this study, however, is that there were only 13 samples in each group. The reality is that there is a shortage of available brain tissue to study. If you’d like to learn more about brain tissue donation that will further autism research, visit TakesBrains.org.


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