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New Mouse Model Mimics Brain Abnormalities in Autism
Published October 6, 2014
in Simons Foundation Autism Research Initiative
Mice with mutations in the autism-linked gene WDFY3 have enlarged brains reminiscent of those seen in some children with autism, finds a study published in Nature Communications. The brain overgrowth begins in the womb, the study found. WDFY3 plays a role in autophagy, a process that rids cells of damaged or unneeded parts. Mouse embryos with two copies of the mutant gene have enlarged brains and an excess of immature neurons that divide faster than usual. They also have misdirected patches of neurons. Similar changes have been observed in people with autism.
http://sfari.org/news-and-opinion/news/2014/new-mouse-model-mimics-brain-abnormalities-in-autism
Filed under: Autism News, Autism Research, Autism Science, Brain Development, featured, Mice Study