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Research by Topic: autism brainnet
The predisposition to neuropsychiatric disease involves a complex, polygenic, and pleiotropic genetic architecture. However, little is known about how genetic variants impart brain dysfunction or pathology. We used transcriptomic profiling as a quantitative readout of molecular brain-based phenotypes across five major psychiatric disorders-autism, schizophrenia, bipolar disorder, depression, and alcoholism-compared with matched controls. We identified patterns […]
Remarkably little is known about the postnatal cellular development of the human amygdala. It plays a central role in mediating emotional behavior and has an unusually protracted development well into adulthood, increasing in size by 40% from youth to adulthood. Variation from this typical neurodevelopmental trajectory could have profound implications on normal emotional development. We […]
This year, more than before, scientists were able to show that autism is a spectrum within a spectrum of other neuropsychiatric issues. There are similarities across diagnoses, and genetic profiles of those with autism, ADHD, OCD, bipolar depression and schizophrenia. There were also major accomplishments in understanding the role of the environment, behavioral and pharmacological […]
On this week’s podcast, data obtained from brains of people with autism is reused and re-analyzed so that a new role of mitochondria and their relationship to the activity of synapse genes could be discovered. In addition, cellular stress is seen in the brains of people with autism. What comes first? Mitochondrial dysfunction and cellular […]
Filed under: Autism, autism brainnet, brain tissue, Brown University, cellular stress, featured, Fragile X, FRAXA Research Foundation, genes, mitochondria, NeuroBioBank, NIH, podcast, research, Tuberous Sclerosis, Tuberous Sclerosis Alliance, UCLA
The Spring 2018 issue of the Autism BrainNet newsletter is out now! Among other news, it highlights recent research using its donated brain tissue resources in autism genetics and neuroanatomy, the science campaign Brain Awareness Week, and outreach efforts through Autism Speaks walks around the country. You can view and read this issue here.
On this week’s ASF podcast: By looking directly at the brains of people with autism, researchers at UC Davis MIND Institute, led by Dr. Thomas Avino and Dr. Cyndi Schumann, show a disruption of neuron number in the amygdala in autism. The amygdala is important because it is linked to emotion, fear and anxiety in […]
Researchers at Autism BrainNet node UC Davis MIND Institute found that while typically-developing children gain more neurons in a region of the brain that governs social and emotional behavior, the amygdala, as they become adults, people with ASD do not. The open access research published in PNAS studied 52 postmortem human brains, both neurotypical and […]
Research led by Daniel Geschwind of the University of California, Los Angeles used postmortem brain tissue, including resources from Autism BrainNet, found similar gene expression patterns in the brains of those with autism, schizophrenia, and bipolar disorder. All three conditions show an activation of genes in star-shaped brain cells called astrocytes, and suppression of genes […]
Banking on brains for clues to autism
In a new blog post, ASF CSO Alycia Halladay explains the newest research in understanding the brains of people with autism.
The Icahn School of Medicine at Mount Sinai and UNYTS collaborate to increase brain tissue for autism researchPublished September 12, 2017
The Icahn School of Medicine at Mount Sinai (ISMMS) and Unyts, the designated organ procurement organization for the eight counties of western New York State, announced today a new agreement that will help increase and enhance the quantity of postmortem brain tissue available for critical autism research. Unyts, which coordinates all organ, eye, and tissue donation […]
In a recent study published in Nature, Dr. Shannon Ellis looks past the sequence of genes and uses gene expression profiling to understand the similarities between autism, schizophrenia and bipolar disorder. Using brain tissue from people affected with these disorders provided through the Autism BrainNet, she demonstrates a common decrease in gene expression relating to […]