Research by Topic: gene expression

Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap

Published February 9, 2018 in Science, Gandal, Haney, et al

Research led by Daniel Geschwind of the University of California, Los Angeles used postmortem brain tissue, including resources from Autism BrainNet, found similar gene expression patterns in the brains of those with autism, schizophrenia, and bipolar disorder. All three conditions show an activation of genes in star-shaped brain cells called astrocytes, and suppression of genes […]

Science Magazine Report

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Brain tissue is used to identify commonalities across neuropsychiatric disorders

Published May 25, 2016

In a recent study published in Nature, Dr. Shannon Ellis looks past the sequence of genes and uses gene expression profiling to understand the similarities between autism, schizophrenia and bipolar disorder. ¬†Using brain tissue from people affected with these disorders provided through the Autism BrainNet, she demonstrates a common decrease in gene expression relating to […]

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