Research by Topic: Hyperactivity

SHANK3 Duplication Leads to Hyperactivity in Mice

Published December 17, 2013 in Simons Foundation Autism Research Institute

Mice with a duplication of SHANK3, a gene with strong links to autism, are hyperactive and manic, reports a study published in Nature.The mice produce about 50 percent more SHANK3 protein than their genetically typical counterparts, the scientists found, much like people with an extra copy of the gene do. The mice also show signs of hyperactivity. The team observed on further testing that the SHANK3 mice show behaviors typically seen in people going through manic episodes. The mice are easier to startle, eat more, have disrupted sleeping patterns and show heightened sensitivity to amphetamine. The mice also have spontaneous seizures.

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Autistic Children and Adults Find Calm in “Snoezelen” Room

Published August 27, 2013 in Tampa Bay Times

A multisensory room, known as the Snoezelen room, in an Autism Behavioral Center in St. Petersburg, FL is helping individuals with developmental disabilities by allowing them to regulate how much sensory stimulation they experience while in the room. The light up ball pit, patterns of light projected on the wall, and other forms of sensory stimulation are all controlled by a remote given to the individual. There are 1,200 rooms like this in the United States providing a calming experience for people with autism by giving them an escape from an overstimulating world.

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Study Finds Hyperconnectivity in Certain Brain Regions in Individuals with Autism.

Published June 26, 2013 in JAMA Psychiatry

During a brain study, researchers found that individuals with autism have specific areas of hyperconnectivity in the brain. This supports the theory that unique autistic behaviors stem from differences in brain wiring.

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Study Shows 1/3 of All Children With Autism Have ADHD

Published June 5, 2013 in Kennedy Krieger Institute

During its study, the Kennedy Krieger Institute found that 1/3 of participants who have autism were also diagnosed with ADHD. This could suggest a genetic link between the two conditions.

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Researchers debut SHANK2 mouse, SHANK3 rat

Published November 15, 2011 in SFARI

Researchers debut the SHANK2 mouse and SHANK3 rat at the 2011 Society for Neuroscience annual meeting. SHANK2 belongs to the same family as SHANK3, a well-established autism candidate gene.

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Attention deficit, autism share genetic risk factors

Published August 22, 2011 in SFARI

People with autism and attention deficit hyperactivity disorder (ADHD) share some of the same underlying genetic risk factors, according to a study published this month in Science Translational Medicine. This is one of the first studies to find risk variants that are common to both disorders.In searching for rare copy number variations (CNVs) deletions and duplications in genetic material in people with ADHD, the researchers found more than a dozen regions that include genes implicated in bipolar disorder, schizophrenia, intellectual disability and autism.

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Minocycline Promising in Fragile X Syndrome

Published September 7, 2010 in Medscape Today

Parents of children with fragile X syndrome report that minocycline led to positive improvements in language, attention levels and behavior. They also report experiencing adverse side effects such as mild gastrointestinal issues and some increased irritability.

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Stereotypes and Hyperactivity in Rhesus Monkeys Exposed to IgG from Mothers of Children with Autism

Published August 31, 2008 in Brain Behavior Immunology, Martin, Ashwood, Braunschweig, Cabanlit, Van de Water, Amaral

One proposed cause of ASD is exposure of the fetal brain to maternal autoantibodies during pregnancy [Dalton, P., Deacon, R., Blamire, A., Pike, M., McKinlay, I., Stein, J., Styles, P., Vincent, A., 2003. Maternal neuronal antibodies associated with autism and a language disorder. Ann. Neurol. 53, 533-537]. To provide evidence for this hypothesis, four rhesus […]

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