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Research by Topic: IACC
U.S. Department of Health and Human Services Secretary Alex Azar has designated Dr. Ann E. Wagner of the National Institute of Mental Health (NIMH) as the National Autism Coordinator. In this role, Dr. Wagner will play a vital role in ensuring the implementation of national autism spectrum disorder (ASD) research, services, and support activities across […]
The newly reconstituted and reorganized Interagency Autism Coordinating Committee has released their strategic plan for 2016-2017. To read the full document, click here.
Full Video of Committee on Oversight and Government Reform Hearing: Examining the Federal Response to Autism Spectrum DisordersPublished May 20, 2014
A full video of yesterday’s committee hearing is now available.
The 2013 Strategic Plan Update provides an accounting and overview of the funding and scientific progress in the autism field since the release of the first IACC Strategic Plan in 2009. The 2013 Update describes recent advances in the scientific understanding of ASD, provides information on the progress of each of the 78 IACC Strategic Plan objectives, highlights areas of need and opportunity, and identifies overarching themes that will be important for future advancement of ASD research. In this final version, you will find a single, streamlined table for each Strategic Plan Question that displays both cumulative 5-year funding and notes regarding progress of each objective, which we thought would be helpful to readers.
Maternal Antibodies from Mothers of Children with Autism alter Brain Growth and Social Behavior Development in the Rhesus MonkeyPublished July 9, 2013 in Translational Psychiatry
Antibodies directed against fetal brain proteins of 37 and 73?kDa molecular weight are found in approximately 12% of mothers who have children with autism spectrum disorder (ASD), but not in mothers of typically developing children. This finding has raised the possibility that these immunoglobulin G (IgG) class antibodies cross the placenta during pregnancy and impact brain development, leading to one form of ASD. We evaluated the pathogenic potential of these antibodies by using a nonhuman primate model. IgG was isolated from mothers of children with ASD (IgG-ASD) and of typically developing children (IgG-CON). The purified IgG was administered to two groups of female rhesus monkeys (IgG-ASD; n=8 and IgG-CON; n=8) during the first and second trimesters of pregnancy. Another control group of pregnant monkeys (n=8) was untreated. Brain and behavioral development of the offspring were assessed for 2 years. Behavioral differences were first detected when the macaque mothers responded to their IgG-ASD offspring with heightened protectiveness during early development. As they matured, IgG-ASD offspring consistently deviated from species-typical social norms by more frequently approaching familiar peers. The increased approach was not reciprocated and did not lead to sustained social interactions. Even more striking, IgG-ASD offspring displayed inappropriate approach behavior to unfamiliar peers, clearly deviating from normal macaque social behavior. Longitudinal magnetic resonance imaging analyses revealed that male IgG-ASD offspring had enlarged brain volume compared with controls. White matter volume increases appeared to be driving the brain differences in the IgG-ASD offspring and these differences were most pronounced in the frontal lobes.
Filed under: IACC
For individuals and families affected by ASD, the most meaningful research findings may be ones that address six critical questions they face: When should I be concerned? How can I understand what is happening? What caused this to happen, and can this be prevented? Which treatments and interventions will help? Where can I turn for […]