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Research by Topic: neuropathology
Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap
Published June 26, 2019 in ScienceThe predisposition to neuropsychiatric disease involves a complex, polygenic, and pleiotropic genetic architecture. However, little is known about how genetic variants impart brain dysfunction or pathology. We used transcriptomic profiling as a quantitative readout of molecular brain-based phenotypes across five major psychiatric disorders-autism, schizophrenia, bipolar disorder, depression, and alcoholism-compared with matched controls. We identified patterns […]
https://science.sciencemag.org/content/359/6376/693.long
Filed under: autism brainnet, Autism Research, Autism Science, genetic, neuropathology, Schizophrenia
Podcast: Brain tissue: what has it done for autism lately?
Published June 12, 2017In order to ensure that researchers have enough brain tissue to understand autism spectrum disorders, the education and outreach campaign of the Autism BrainNet is being expanded past families to doctors and professionals that have access to tissue. One of these groups is neuropathologists. At their annual meeting this past week in Los Angeles, an […]
Filed under: Autism, brain, featured, neuropathology