Research by Topic: neuropathology

Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap

Published June 26, 2019 in Science

The predisposition to neuropsychiatric disease involves a complex, polygenic, and pleiotropic genetic architecture. However, little is known about how genetic variants impart brain dysfunction or pathology. We used transcriptomic profiling as a quantitative readout of molecular brain-based phenotypes across five major psychiatric disorders-autism, schizophrenia, bipolar disorder, depression, and alcoholism-compared with matched controls. We identified patterns […]

https://science.sciencemag.org/content/359/6376/693.long

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Podcast: Brain tissue: what has it done for autism lately?

Published June 12, 2017

In order to ensure that researchers have enough brain tissue to understand autism spectrum disorders, the education and outreach campaign of the Autism BrainNet is being expanded past families to doctors and professionals that have access to tissue. One of these groups is neuropathologists. At their annual meeting this past week in Los Angeles, an […]

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