Research by Topic: RNA

Transcriptome-wide isoform-level dysregulation in ASD, schizophrenia, and bipolar disorder

Published June 26, 2019 in Science

Most genetic risk for psychiatric disease lies in regulatory regions, implicating pathogenic dysregulation of gene expression and splicing. However, comprehensive assessments of transcriptomic organization in diseased brains are limited. In this work, we integrated genotypes and RNA sequencing in brain samples from 1695 individuals with autism spectrum disorder (ASD), schizophrenia, and bipolar disorder, as well […]

https://science.sciencemag.org/content/362/6420/eaat8127.long

Filed under: , , , ,