Research by Topic: Schizophrenia

Transcriptome-wide isoform-level dysregulation in ASD, schizophrenia, and bipolar disorder

Published June 26, 2019 in Science

Most genetic risk for psychiatric disease lies in regulatory regions, implicating pathogenic dysregulation of gene expression and splicing. However, comprehensive assessments of transcriptomic organization in diseased brains are limited. In this work, we integrated genotypes and RNA sequencing in brain samples from 1695 individuals with autism spectrum disorder (ASD), schizophrenia, and bipolar disorder, as well […]

https://science.sciencemag.org/content/362/6420/eaat8127.long

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Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap

Published June 26, 2019 in Science

The predisposition to neuropsychiatric disease involves a complex, polygenic, and pleiotropic genetic architecture. However, little is known about how genetic variants impart brain dysfunction or pathology. We used transcriptomic profiling as a quantitative readout of molecular brain-based phenotypes across five major psychiatric disorders-autism, schizophrenia, bipolar disorder, depression, and alcoholism-compared with matched controls. We identified patterns […]

https://science.sciencemag.org/content/359/6376/693.long

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Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap

Published February 9, 2018 in Science, Gandal, Haney, et al

Research led by Daniel Geschwind of the University of California, Los Angeles used postmortem brain tissue, including resources from Autism BrainNet, found similar gene expression patterns in the brains of those with autism, schizophrenia, and bipolar disorder. All three conditions show an activation of genes in star-shaped brain cells called astrocytes, and suppression of genes […]

Science Magazine Report

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Brain tissue is used to identify commonalities across neuropsychiatric disorders

Published May 25, 2016

In a recent study published in Nature, Dr. Shannon Ellis looks past the sequence of genes and uses gene expression profiling to understand the similarities between autism, schizophrenia and bipolar disorder.  Using brain tissue from people affected with these disorders provided through the Autism BrainNet, she demonstrates a common decrease in gene expression relating to […]

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ASF grantee proposes new way to diagnose people with autism

Published August 30, 2015

Jennifer Foss-Feig, PhD at Yale University recently received an accelerator grant to expand her research project to include individuals with autism. Why? She theorizes that the way schizophrenia is classified and conceptualized may be helpful to the diagnosis of autism spectrum disorder. She recently published these ideas and wrote a blog for the ASF. You can read it here: https://autismsciencefoundation.wordpress.com/2015/08/24/is-it-time-to-rethink-the-symptoms-of-autism-a-commentary-by-jennifer-foss-feig-phd-yale-university/

https://autismsciencefoundation.wordpress.com/2015/08/24/is-it-time-to-rethink-the-symptoms-of-autism-a-commentary-by-jennifer-foss-feig-phd-yale-university/

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