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Research by Topic: Siblings
Genes, environment and heritability: why does it matter?
Published July 29, 2019 in ASF PodcastThis week a 5 country collaboration including the largest number of people EVER revealed 80% of the causes of autism are heritable. This is incredibly important to understand autism and move forward with research that matters to families. What it did not do was calculate the role of gene x environment interactions which seems to […]
https://asfpodcast.org/archives/794
Filed under: Autism Research, Autism Science, Diagnosis, epidemiology, gene x environment interactions, risk, Siblings
DSM5 – where are we now?
Published July 1, 2019 in ASF PocastDon’t be fooled, not all the studies on this week’s podcast focus on the DSM5. But the first one, a review of a meta analysis and review of the dozens of publications that have emerged in the past 5 years around the DSM5 leads us off. There are some people that weren’t captured by either […]
https://asfpodcast.org/archives/722
Filed under: Autism Research, Autism Science, broader autism phenotype, DSM, epidemiology, podcast, risk, Siblings
Vaccination Patterns in Children After Autism Spectrum Disorder Diagnosis and in Their Younger Siblings
Published June 26, 2019 in JAMA PediatricsIMPORTANCE: In recent years, rates of vaccination have been declining. Whether this phenomenon disproportionately affects children with autism spectrum disorder (ASD) or their younger siblings is unknown. OBJECTIVES: To investigate if children after receiving an ASD diagnosis obtain their remaining scheduled vaccines according to the Advisory Committee on Immunization Practices (ACIP) recommendations and to compare […]
https://jamanetwork.com/journals/jamapediatrics/fullarticle/2676070
Filed under: risk, Siblings, vaccination
A longitudinal study of parent-reported sensory responsiveness in toddlers at-risk for autism
Published June 26, 2019 in The Journal of Child Psychology and PsychiatryBACKGROUND: Atypical sensory responsivity and sensory interests are now included in the DSM 5 diagnostic criteria for autism spectrum disorder (ASD) under the broad domain of restricted and repetitive behavior (RRB). However, relatively little is known about the emergence of sensory-related features and their relation to conventionally defined RRB in the first years of life. […]
https://onlinelibrary.wiley.com/doi/abs/10.1111/jcpp.12978
Filed under: Autism Research, Autism Science, Infants, Repetitive Behavior, Sensory Issues, Siblings
Infant viewing of social scenes is under genetic control and is atypical in autism
Published June 24, 2019 in natureLong before infants reach, crawl or walk, they explore the world by looking: they look to learn and to engage, giving preferential attention to social stimuli, including faces, face-like stimuli and biological motion. This capacity-social visual engagement-shapes typical infant development from birth and is pathognomonically impaired in children affected by autism. Here we show that […]
https://www.nature.com/articles/nature22999
Filed under: Autism Research, Autism Science, Biomarkers, Infants, Siblings, Social Skills
Early brain development in infants at high risk for autism spectrum disorder
Published June 24, 2019 in natureBrain enlargement has been observed in children with autism spectrum disorder (ASD), but the timing of this phenomenon, and the relationship between ASD and the appearance of behavioural symptoms, are unknown. Retrospective head circumference and longitudinal brain volume studies of two-year olds followed up at four years of age have provided evidence that increased brain […]
https://www.nature.com/articles/nature21369
Filed under: Autism Research, Autism Science, Biomarkers, Infants, prediction, Siblings, Toddlers
Functional neuroimaging of high-risk 6-month-old infants predicts a diagnosis of autism at 24 months of age
Published June 24, 2019 in Science Translational MedicineAutism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by social deficits and repetitive behaviors that typically emerge by 24 months of age. To develop effective early interventions that can potentially ameliorate the defining deficits of ASD and improve long-term outcomes, early detection is essential. Using prospective neuroimaging of 59 6-month-old infants with a high […]
https://stm.sciencemag.org/content/9/393/eaag2882.short
Filed under: Autism Research, Autism Science, Biomarkers, infant, prediction, Siblings
EEG Analytics for Early Detection of Autism Spectrum Disorder: A data-driven approach
Published June 19, 2019 in Scientific ReportsAutism spectrum disorder (ASD) is a complex and heterogeneous disorder, diagnosed on the basis of behavioral symptoms during the second year of life or later. Finding scalable biomarkers for early detection is challenging because of the variability in presentation of the disorder and the need for simple measurements that could be implemented routinely during well-baby […]
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5931530/
Filed under: Autism Research, Autism Science, Biomarkers, Brain Development, Infants, Siblings
Podcast: Super siblings!
Published October 15, 2018This podcast is dedicated to siblings of people with autism who are typically developing. They play an important and beneficial role in development of socialization of those with ASD. But sadly, they also have issues of their own, such as a high rate of issues like anxiety and depression. Those siblings may be genetic carries […]
Filed under: advocates, anxiety, ASD, asf, Autism, children, community, depression, Family, featured, podcast, Siblings
ASF renews grant to expand Baby Sibs research
Published July 2, 2018ASF is proud to announce continued support for the Baby Siblings Research Consortium (BSRC), a network of over 33 research sites around the world studying the younger siblings of people with autism. The Baby Sibs database now tracks over 5,000 younger siblings, with and without autism. The database has been used to develop more sophisticated […]
Filed under: asf, baby siblings, Baby Siblings Research Consortium, Baby Sibs, Behavior, BSRC, collaboration, consortium, early diagnosis, Early Intervention, Family, featured, genes, intervention, research, science, sex difference, Siblings
ASF’s 2018 summer intern shares her experience
Published June 13, 2018ASF’s summer intern Seowon Song shared her experience as an autism sibling on the ASF blog. In January 2016, she helped develop a support group for siblings of those with autism in South Korea named “Nanun”. The group published a book of their stories in March 2018. You can read the blog in English and […]
Filed under: acceptance, advocacy, asf, Autism, awareness, blog, featured, Siblings, South Korea, summer intern, support
Podcast: When can you see autism in the brain?
Published February 20, 2017This week the Infant Brain Imaging Study, or IBIS, published it’s second study on the emergence of changes in the brains of individuals with autism. While red flags for autism can be seen early, a diagnosis of autism is not typically made until after 24 months of age. Using a baby sibling research design, scientists showed […]
Filed under: autismr, featured, infant, research, Siblings
Unfortunate new risk discovered for people with autism and their siblings
Published October 17, 2016In addition to risks of anxiety, ADHD, mood disorders and other psychiatric issues, people with autism (and their siblings) show increased risk of substance abuse issues. This information comes from a large Scandinavian registry study that included over 26,000 individuals with ASD. On this week’s podcast Dr. Alycia Halladay Ross discusses what this means for […]
Filed under: ADHD, anxiety, Autism, featured, Siblings
New podcast on research in siblings
Published October 11, 2016Two studies recently add to an ever-growing body of literature around undiagnosed siblings of individuals with autism. While in autism features there is evidence of the “broader autism phenotype” in female siblings, there is no evidence of elevated sensory symptoms in those with a brother or system with autism. The more we understand about the […]
Filed under: Autism, featured, Siblings
New podcast examines the broader autism phenotype in siblings
Published August 4, 2016Siblings of individuals with autism, and sometimes parents, can show mild features of autism that don’t meet ASD diagnostic criteria. This is called the broader autism phenotype. Sometimes they also show emotional and behavior problems, ADHD, tic disorder and an autism diagnosis. This week’s podcast summaries new findings on the broader autism phenotype with the […]
Filed under: ADHD, broader autism phenotype, dup15, featured, Finland, mental health, Siblings
Summer Institute presentation focuses on importance of studying infant siblings
Published June 21, 2016 in http://www.autism-insar.org/research-opportunities/summer-institute2016Dr. Joseph Piven, member of the High Risk Baby Siblings Research Consortium, will present a 2 hour webinar as part of the INSAR Summer Institute on June 30th at 2PM – 4PM EST. To learn more or register, click here: http://www.autism-insar.org/research-opportunities/summer-institute2016
Filed under: family members, featured, high risk, infant, Siblings
Increased Risk of Psychiatric and Neurodevelopmental Disorders in Siblings
Published May 5, 2016In a new study published JAMA Pediatrics yesterday examined psychiatric records of siblings of people with autism living in Finland. They found the rates of ASD, ADHD, ID, childhood emotional disorders, learning and coordination disorders, conduct and oppositional disorders, and tic disorders, were more frequent among siblings of siblings with ASD. Also, there was an increase in schizophrenia […]
Filed under: ADHD, Autism, common disorders, epidemiology, featured, recurrence, Risk Factors, Siblings
Occurrence and Family Impact of Elopement in Children with Autism Spectrum Disorders
Published November 8, 2015 in PediatricsThis study assessed parent-reported elopement occurrence and associated factors among children with Autism Spectrum Disorders (ASD)s.
http://www.ncbi.nlm.nih.gov/pubmed/
Filed under: Autism News, Autism Research, Autism Science, Siblings, Wandering
Examining and Interpreting the Female Protective Effect against Autistic Behavior
Published February 19, 2013 in Proceedings of the National Academy of SciencesThis study examined the hypothesis that a protective component of the female sex protects females from autistic behavioral impairment. The results indicate that greater familial risk may be associated with ASD in females, and males may require fewer familial risk factors to reach a similar impairment threshold. The authors hope the study will provide insight into the ASD sex ratio and aid future genetic research.
http://www.pnas.org/content/early/2013/02/13/1211070110.abstract
Filed under: Autism Research, Autism Science, Behavior, featured, Gender, Siblings
Autisms Invisible Victims: The Siblings
Published November 30, 2012 in TimeEarlier this week, Rep. Darrell Issa, Chairman of the Committee on Oversight & Government Reform held a hearing on how the federal government can better respond to the dramatic rise in autism rates. Yet for all this concern, one large affected group is being routinely overlooked: the siblings.
http://ideas.time.com/2012/11/30/autisms-invisible-victims-the-siblings/
Filed under: Family, featured, Siblings
Object Exploration at 6 and 9 Months in Infants with and without Risk for Autism
Published November 22, 2012 in AutismCo-authored by ASF grantee Nina Leezenbaum, this study found delayed visual and oral exploration of objects in infant siblings of children with autism that were not observed in infants with no family history.
http://aut.sagepub.com/content/early/2012/11/20/1362361312464826
Filed under: Baby Sibs, featured, Infants, Siblings
Atypical Activation During the Embedded Figures Task as a Functional Magnetic Resonance Imaging Endophenotype of Autism
Published October 11, 2012 in BrainThis study uncovers a possible fMRI endophenotype of autism, showing that compared to typically developing controls with no family history of ASD, adolescents with autism and non-autistic siblings had atypical patterns of brain activation during the Embedded Figures Task.
http://brain.oxfordjournals.org/content/early/2012/10/11/brain.aws229.long
Filed under: Biomarkers, Brain Imaging, featured, Siblings
Immunization Uptake in Younger Siblings of Children with Autism Spectrum Disorder.
Published October 8, 2012 in AutismStudy finds that parents who already have one child with autism spectrum disorder may delay or decline immunization for their younger children, potentially placing them at increased risk of preventable infectious diseases.
http://www.ncbi.nlm.nih.gov/pubmed/23045216#
Filed under: featured, Siblings, Vaccines
The Development of Referential Communication and Autism Symptomatology in High-Risk Infants
Published October 1, 2012 in InfancyThis study suggests that non-verbal communication delays in infants with autistic siblings can predict later ASD symptoms.For a Science Daily article on this paper, click here: http://www.sciencedaily.com/releases/2012/10/121001124802.htm
http://onlinelibrary.wiley.com/doi/10.1111/j.1532-7078.2012.00142.x/abstract
Filed under: Baby Sibs, Early Intervention, featured, Screening, Siblings, Social Interaction, Toddlers
De novo mutations revealed by whole-exome sequencing are strongly associated with autism.
Published April 4, 2012 in PubMedAmong a total of 279 identified de novo coding mutations, there is a single instance in probands, and none in siblings, in which two independent nonsense variants disrupt the same gene, SCN2A (sodium channel, voltage-gated, type II, ? subunit), a result that is highly unlikely by chance.
http://www.ncbi.nlm.nih.gov/pubmed/22495306
Filed under: Autism Research, Autism Science, Siblings
IACC Releases Its 2011 Summary of Advances in Autism Spectrum Disorder Research
Published April 2, 2012 in IACCOn April 2, in honor of the fifth annual World Autism Awareness Day and HHS Autism Awareness Month the IACC has released its annual list of scientific advances that represent significant progress in the field.
IACC Releases Its 2011 Summary of Advances in Autism Spectrum Disorder Research
Filed under: Adults, Baby Sibs, Diagnosis, Early Intervention, featured, Genetics, Screening, Service Delivery, Siblings, Treatments
New Data Show Children With Autism Bullied Three Times More Frequently Than Their Unaffected Siblings
Published March 26, 2012 in MarketWatchToday, the Interactive Autism Network (IAN), www.ianproject.org , the nation’s largest online autism research initiative and a project of the Kennedy Krieger Institute, reports preliminary results of the first national survey to examine the impact of bullying on children with autism spectrum disorders (ASD). The results show that 63 percent of children with ASD have been bullied at some point in their lives. These children, who are sometimes intentionally “triggered” into meltdowns or aggressive outbursts by peers, are bullied three times more frequently than their siblings who do not have ASD.
Filed under: Behavior, featured, Service Delivery, Siblings, Social Skills
Mothers of Autistic Children Earn 56% Less Income, Study Says
Published March 19, 2012 in CBS NewsOn average, families with a child who has autism earn 28% less than those of a child without a health limitation; nearly $18,000 less per year.
Mothers of Autistic Children Earn 56% Less Income, Study Says
Filed under: Family, featured, Mothers, Service Delivery, Siblings
New Research Suggests Birth Weight Plays A Role In Autism Spectrum Disorder
Published January 23, 2012 in Medical News TodayAlthough the genetic basis of autism is now well established, a growing body of research also suggests that environmental factors may play a role. Using a unique study design, a new study suggests that low birth weight is an important environmental factor contributing to the risk of autism spectrum disorder (ASD).
New Research Suggests Birth Weight Plays A Role In Autism Spectrum Disorder
Filed under: Diagnosis, Diagnostic Disparities, featured, Genetics, Siblings
Genetic Heritability and Shared Environmental Factors Among Twin Pairs with Autism
Published November 1, 2011 in Archives of General PsychiatryRecent research suggests that environmental factors may play a much greater role in autism risk than previously suspected and could even be more influential than genetic factors. These findings stem from a study of autism in twins, the largest of its kind, designed to model the genetic and environmental factors that contribute to the development […]
http://www.ncbi.nlm.nih.gov/pubmed/21727249
Filed under: Genetics, Siblings
Recurrence Risk for Autism Spectrum Disorders: A Baby Siblings Research Consortium Study
Published August 1, 2011 in Pediatrics, Ozonoff et al.A study published August 15, 2011 in the journal Pediatrics found that infants with an older autistic sibling have a near 19 percent risk that they too will develop the disorder. The study is considered the largest autism study to follow infants for sibling recurrence.
http://pediatrics.aappublications.org/content/early/2011/08/11/peds.2010-2825.abstract
Filed under: Baby Sibs, Genetics, Siblings
Rare De Novo and Transmitted Copy-Number Variation in Autistic Spectrum Disorders
Published June 9, 2011 in NeuronA study of the genetic causes of autism confirmed that spontaneous or de novo mutations are present in a substantial number of families with only one child on the spectrum. These de novo mutations are not inherited from parents' DNA, arising instead in their egg or sperm or very early in embryonic development. Researchers compared […]
http://www.ncbi.nlm.nih.gov/pubmed/21658582
Filed under: Copy Number Variations, Genetics, Siblings
Gene Linked to Severity of Autism’s Social Dysfunction Identified
Published April 7, 2011 in Science DailyWith the help of two sets of brothers with autism, Johns Hopkins scientists have identified a gene associated with autism that appears to be linked very specifically to the severity of social interaction deficits. The gene, GRIP1 (glutamate receptor interacting protein 1), is a blueprint for a traffic-directing protein at synapses — those specialized contact points between brain cells across which chemical signals flow.
http://www.sciencedaily.com/releases/2011/04/110406123019.htm
Filed under: Animal Models, Applied Behavior Analysis, Genetics, Genomics, Siblings, Social Skills, Synapse
Autism Risk Linked To Space Between First And Second Pregnancy
Published January 10, 2011 in Medical News TodayA second child is three times more likely to be diagnosed with autism if they are born within twelve months of their siblings, compared to those born three or more years apart, researchers from the Lazarsfeld Center for the Social Sciences at Columbia University, New York revealed in the journal Pediatrics. The investigators gathered information on 660,000 second children born in California between 1992 to 2002.
http://www.medicalnewstoday.com/articles/213245.php
Filed under: Baby Sibs, Diagnosis, Diagnostic Disparities, Genetics, Siblings
Neural Signatures of Autism
Published December 1, 2010 in PNAS, Kaiser, Hudack, Schultz, Lee, Cheung, Berken, Deen, Pitskel, Sugrue, Voos, Saulnier, Ventola, Wolf, Klin, Vander Wyk, PelphreyThese findings of this study hold far-reaching implications for our understanding of the neural systems underlying autism. Using FMRI to record the biological motion of children with autism spectrum disorder, unaffected siblings of children with ASD, and typically developing children, the study reveals three types of neural signatures: The study finds distinct brain responses to […]
http://www.ncbi.nlm.nih.gov/pubmed/21078973
Filed under: Baby Sibs, Brain Imaging, Screening, Siblings
Brain Scans Detect Autism’s Signature
Published November 16, 2010 in Science DailyAn autism study by Yale School of Medicine researchers using functional magnetic resonance imaging (fMRI) has identified a pattern of brain activity that may characterize the genetic vulnerability to developing autism spectrum disorder (ASD). The team identified three distinct “neural signatures”: trait markers — brain regions with reduced activity in children with ASD and their unaffected siblings; state markers — brain areas with reduced activity found only in children with autism; and compensatory activity — enhanced activity seen only in unaffected siblings. The enhanced brain activity may reflect a developmental process by which these children overcome a genetic predisposition to develop ASD.
http://www.sciencedaily.com/releases/2010/11/101115161253.htm
Filed under: Biomarkers, Brain Development, Brain Imaging, Genetics, Siblings
Siblings of Autistic Children May Have Some Autism Related Traits, Study Says
Published October 11, 2010 in LA TimesScientists at the Washington University School of Medicine have uncovered more evidence of a genetic basis for autism. Reviewing surveys collected from more than 1,000 families with autistic kids, they discovered that siblings of autistic children who have not been diagnosed with the disease often exhibit mild traits of autism, including speech delays.
http://www.latimes.com/health/boostershots/la-heb-autism-20101011,0,976254.story
Filed under: Baby Sibs, Siblings, Speech
Language Delays Found in Siblings of Children with Autism
Published October 3, 2010 in Medical News TodayA new study, led by researchers at Washington University School of Medicine in St. Louis, found mild traits, not strong enough to provoke a diagnosis of autism, seem to be present in the siblings of affected children at significantly higher rates than seen in the general population. Siblings of children with autism have more frequent language delays and other subtle characteristics of the disorder than previously understood. Girls also may be mildly affected more often than recognized in the past.
http://www.medicalnewstoday.com/articles/203249.php
Filed under: Diagnosis, Diagnostic Disparities, Gender, Genetics, Language, Siblings, Speech
Link to Autism in Boys Found in Missing DNA
Published September 15, 2010 in Science DailyIf a boy’s X-chromosome is missing the PTCHD1 gene or other nearby DNA sequences, they will be at high risk of developing ASD or intellectual disability. Girls are different in that, even if they are missing one PTCHD1 gene, by nature they always carry a second X-chromosome, shielding them from ASD.
http://www.sciencedaily.com/releases/2010/09/100915150951.htm
Filed under: Biomarkers, Brain Development, Diagnosis, Diagnostic Disparities, Gender, Genetics, Siblings
Prenatal and Infant Exposure to Thimerosal from Vaccines and Immunoglobulins and Risk of Autism
Published September 1, 2010 in Pediatrics, Price et alThis new study in the journal of Pediatrics indicated that there was no increased risk of Autism Spectrum Disorder associated with receipt of thimerosal-containing vaccines. The study also found no increased risk for any of the subtypes of Autism Spectrum Disorder, including ASD with regression. In addition, it found no increased risk of Autism Spectrum […]
Filed under: Gender, Siblings, Thimerosal, Vaccines
Infants Gaze May Be an Early, but Subtle, Marker for Autism Risk
Published September 1, 2010 in Science DailyKennedy Krieger Institute have announced new study results showing an early marker for later communication and social delays in infants at a higher-risk for autism may be infrequent gazing at other people when unprompted. The study also found that six-month-old high-risk infants demonstrated the same level of cause and effect learning skills when compared to low-risk infants of the same age.
http://www.sciencedaily.com/releases/2010/09/100901111628.htm
Filed under: Baby Sibs, Behavior, Biomarkers, Diagnosis, Early Intervention, Eye Tracking, Screening, Siblings, Social Skills
New Research Raises Hope that Autism Effects May Be Reversible
Published April 22, 2010 in Medical News TodayA new study by researchers at The George Washington University School of Medicine and Health Sciences’ Department of Biochemistry and Molecular Biology raises hope that autism may be more easily diagnosed and that its effects may be more reversible than previously thought. Researchers have identified potentially removable chemical tags (called “methyl groups”) on specific genes of autistic individuals that led to gene silencing. They also observed these changes in cells derived from blood, opening the way to molecular screening for autism using a blood test.
http://www.medicalnewstoday.com/articles/186262.php
Filed under: Diagnosis, Genetics, Screening, Siblings, Treatments
New Study Of Autism Reveals a ‘DNA tag’ Amenable To Treatment
Published April 8, 2010 in EurekAlertA new discovery raises hope that autism may be more easily diagnosed and that its effects may be more reversible than previously thought. In a new study appearing online in The FASEB Journal, scientists have identified a way to detect the disorder using blood and have discovered that drugs which affect the methylation state (“DNA tagging”) of genes could reverse autism’s effects. This type of drug is already being used in some cancer treatments.
http://www.eurekalert.org/pub_releases/2010-04/foas-nso040810.php
Filed under: Diagnosis, Genetics, Screening, Siblings, Treatments
Autism’s Earliest Symptoms Not Evident in Children Under 6 Months
Published February 16, 2010 in Science DailyA study of the development of autism in infants, comparing the behavior of the siblings of children diagnosed with autism to that of babies developing normally, has found that the nascent symptoms of the condition — a lack of shared eye contact, smiling and communicative babbling — are not present at 6 months, but emerge gradually and only become apparent during the latter part of the first year of life.
http://www.sciencedaily.com/releases/2010/02/100216091009.htm
Filed under: Baby Sibs, Diagnosis, Diagnostic Disparities, Early Intervention, Eye Tracking, Screening, Siblings
Genes Implicated in Twins’ Autism
Published January 4, 2010 in The Baltimore SunResearchers have known for years that when one identical twin has autism, the other is also likely to be diagnosed with it – evidence that autism likely has a genetic component. Recent studies support that theory. Researchers at Kennedy Krieger Institute studied 277 pairs of twins and found that when one identical twin had the disorder, the other developed it 88 percent of the time; for fraternal twins, that figure was 31 percent.
http://www.baltimoresun.com/health/bal-md.hs.autism04jan04,0,7145703.story
Filed under: Diagnosis, Diagnostic Disparities, Genetics, Siblings
California Dept of Health Publishes Study on Autism and Maternal/Paternal Age
Published October 5, 2009 in American Journal of EpidemiologyReviewing a larger population than in any other study of its kind, the California Department of Public Health (CDPH) has found that as parents age their risk of giving birth to a child with autism increases modestly. Published in the American Journal of Epidemiology, the new CDPH study shows that for each 10-year increase in a mothers age, the risk of autism increased by about 38 percent. For each 10-year increase in a fathers age, the risk of autism increased by about 22 percent.
http://www.cdph.ca.gov/Pages/NR09-87-CDPHPUBLISHESSTUDYONAUTISMANDMATERNALANDPATERNALAGE.aspx
Filed under: Adults, Biomarkers, Diagnosis, Diagnostic Disparities, Mothers, Siblings
High-density SNP association study of the 17q21 chromosomal region linked to autism identifies CACNA1G as a novel candidate gene
Published May 1, 2009 in Molecular Psychiatry, Strom, Stone, Bosch, Merriman, Cantor, Geschwind, and Nelson(From a UCLA press release) UCLA scientists have discovered a variant of a gene called CACNA1G that may increase a child's risk of developing autism, particularly in boys. "We found that a common form of the gene occurs more frequently in the DNA of families that have two or more sons affected by autism, but […]
http://www.nature.com/mp/journal/vaop/ncurrent/abs/mp200941a.html
Filed under: Biomarkers, Gender, Genetics, Siblings
Structural Variation of Chromosomes in Autism Spectrum Disorder
Published February 28, 2008 in American Journal of Human Genetics, Marshall, Noor, et alStructural variation (copy number variation [CNV] including deletion and duplication, translocation, inversion) of chromosomes has been identified in some individuals with autism spectrum disorder (ASD), but the full etiologic role is unknown. We performed genome-wide assessment for structural abnormalities in 427 unrelated ASD cases via single-nucleotide polymorphism microarrays and karyotyping. With microarrays, we discovered 277 […]
http://www.ncbi.nlm.nih.gov/pubmed/18252227
Filed under: Baby Sibs, Copy Number Variations, Genomics, Siblings