- About ASF
- What is Autism?
- How Common is Autism?
- Early Signs of Autism
- Autism Diagnosis
- Following a Diagnosis
- Treatment Options
- Beware of Non-Evidence-Based Treatments
- Autism and Vaccines
- Autism Science
- Quick Facts About Autism
- What We Fund
- Autism Sisters Project
- Baby Siblings Research Consortium
- Resources for Grantees
- Funding Calendar
- ASF Funded Research
- ASF Supported Findings
- Apply for a Fellowship
- Apply for a Research Accelerator Grant
- Apply for an Undergraduate Summer Research Grant
- Get Involved
- Day of Learning
- Year End Summaries
- Contact Us
Research by Topic: Social Skills
On this week’s ASF podcast, regression—what is it and who can see it? Using the right tools, both parents and clinicians can see that many more children with autism than thought show regression, a gradual decline or loss of skills starting at around 12 months of age and showing continual declines until 36 months of […]
Effects of Risperidone and Parent Training on Adaptive Functioning in Children with Pervasive Developmental Disorders and Serious Behavioral ProblemsPublished February 8, 2015 in J Am Acad Child Adolesc Psychiatry
Children with Pervasive Developmental Disorders (PDDs) have social interaction deficits, delayed communication, and repetitive behaviors as well as impairments in adaptive functioning. Many children actually show a decline in adaptive skills compared with age mates over time.
Seaside Therapeutics has discontinued their extension study of Arbaclofen (STX209), a drug that showed promise in treating social impairment related to Fragile X syndrome.
Researchers have demonstrated that brain responses to words in children with autism at age two may strongly predict cognitive ability, receptive language and adaptive behavior in those children at ages 4 and 6.
The editors of Molecular Autism, Dr. Simon Baron-Cohen and ASF SAB member Dr. Joe Buxbaum, invited the labs of Dr. Cathy Lord and Dr. Fred Volkmar to offer their perspectives on the new DSM-5 criteria for the autism spectrum.Read Dr. Lord’s commentary here: http://www.molecularautism.com/content/pdf/2040-2392-4-12.pdfRead Dr. Volkmar’s commentary here: http://www.molecularautism.com/content/pdf/2040-2392-4-13.pdf
A recent pilot study linked the JASPER intervention (Joint Attention Symbolic Play Engagement and Regulation) to core deficit improvement in minimally verbal 3 to 5 year olds with autism.
Cognitive Enhancement Therapy for Adults with Autism Spectrum Disorder: Results of an 18-month Feasibility StudyPublished April 26, 2013 in Journal of Autism and Developmental Disorders
New findings from a small pilot study suggest cognitive enhancement therapy is a feasible and effective intervention for cognitive impairments in verbal adults with ASD. Adult participants were highly satisfied with the therapy and treatment attendance was high, indicating their willingness to participate in and commit to an intervention that they considered useful.
In an attempt to raise awareness of the unique obstacles faced by young adults with ASD, researchers compared their social experiences with the experiences of young adults who received special education services for intellectual disability, emotional disturbance, or learning disability and found young adults with ASD experienced significantly more social isolation.
Two recent studies have linked mind-blindness to atypical patterns of brain activity in people with ASD.
Bridges and Barriers to Successful Transitioning as Perceived by Adolescents and Young Adults With Asperger SyndromePublished March 28, 2013 in Journal of Pediatric Nursing
This thematic content analysis examined the expectations, and perceived facilitators of and barriers to transition to community as reported by adolescents and young adults with Asperger syndrome.
Sleep disruption as a correlate to cognitive and adaptive behavior problems in autism spectrum disorders.Published March 25, 2013 in PubMed
Results suggested that children who slept fewer hours per night had lower overall intelligence, verbal skills, overall adaptive functioning, daily living skills, socialization skills, and motor development.
Children with ASD showed increased positive social behaviors in the presence of guinea pigs compared to toys in this new PLOS One study. Specifically, they showed more social approach behaviors (e.g. talking, looking at faces and making tactile contact) and positive affect (e.g. laughing and smiling), and less self-focused behaviors in the presence of animals.
Social stories, an intervention used to define a skill, concept or situation in socially appropriate terms, were used to promote self-regulation techniques in a self-contained preschool classroom. While implementation of self-regulation strategies varied among the children, all showed an increase in desired behaviors with the intervention.
This interesting preliminary study examined whether typical mice could recognize atypical social behavior in ASD mouse models. Wild-type mouse ‘judges’ preferred to be in chambers with other typical mice rather than socially atypical mice, suggesting that typical mice can distinguish mice displaying autism-like behavior from controls.
The age at which a child with autism is diagnosed is related to the particular suite of behavioral symptoms he or she exhibits, according to this study led by an ASF Grantee. Certain diagnostic features, including poor nonverbal communication and repetitive behaviors, were associated with earlier identification of an autism spectrum disorder. Displaying more behavioral features was also associated with earlier diagnosis.For more information about this study, read the guest blog from the lead author here: http://autismsciencefoundation.wordpress.com/2013/04/09/identifying-asd-in-community-settings/
Brief Report: Is Cognitive Rehabilitation Needed in Verbal Adults with Autism? Insights from Initial Enrollment in a Trial of Cognitive Enhancement TherapyPublished February 5, 2013 in Journal of Autism and Developmental Disorders
Early results from this pilot trial of cognitive enhancement therapy (CET) indicate that despite above-average intelligence, verbal adults with ASD can have significantly impaired neurocognition and social cognition. The authors suggest CET, which is designed to remediate both social and non-social deficits through computer-based neurocognitive training, could be useful for cognitive rehabilitation in this population.
Familiarity Breeds Support: Speech-language Pathologists Perceptions of Bullying of Students with Autism Spectrum DisordersPublished January 31, 2013 in Journal of Communication Disorders
According to this study, school-based speech language pathologists may be an untapped resource in the fight against bullying of children with ASD.
Decreased Spontaneous Attention to Social Scenes in 6-Month-Old Infants Later Diagnosed with Autism Spectrum DisordersPublished January 14, 2013 in Biological Psychiatry
Yale researchers used eye-tracking technology to examine social monitoring skills of infants at high and low risk for autism. Compared to infants who developed typically, six-month olds later diagnosed with ASD looked less at the social scene, which involved a woman engaged in various activities. When they did attend to the social scene, they spent less time viewing the womans face.
Results from this preliminary study suggest that an interactive virtual reality game can improve social communication skills in teens with ASD.
According to this recent meta-analysis of fMRI studies, autism-related changes in brain activity may continue to develop with age.
Neural Mechanisms of Improvements in Social Motivation After Pivotal Response Treatment: Two Case StudiesPublished October 27, 2012 in Journal of Autism and Developmental Disorders
Researchers find increased activation to social stimuli in brain regions involved in social perception in two children with ASD after pivotal response treatment (PRT).
This fMRI study on social judgment supports claims that autistic children may recognize socially inappropriate behavior but find it difficult to express why its inappropriate.
In this new review of intervention studies targeting social impairment in autism, authors encourage researchers to design new studies that: evaluate ingredients of effective interventions (e.g., required dose for therapeutic effect); include better outcome measures that can show that meaningful improvements have happened (e.g., spontaneous social initiations; sustained interactions); and include underserved and underrepresented participant groups, such as children with comorbidities, non-English speaking children, and minimally verbal children.
Early Behavioral Intervention is Associated with Normalized Brain Activity in Young Children with AutismPublished August 31, 2012 in Journal of the American Academy of Child & Adolescent Psychiatry
This randomized trial associated ESDM with normalized brain activity and behavioral improvements in young children with ASD.
Researchers at Stanford University have found that adults with autism spectrum disorders report greater levels of negative emotion in general.
Researchers at Stanford University have found that adults with autism spectrum disorders report greater levels of negative emotion in general.
Researchers in France found that children with autism who became pet owners after the age of 5 performed better than children without pets on two key measures of social functioning — offering comfort and offering to share. Having a pet from birth did not appear to influence the socialization behaviors, leading the researchers to conclude that the arrival of a pet when a child is old enough to recognize the addition may be critical.
Researchers discuss the association between schizophrenia, bipolar disorder and ASD, and suggest the conditions share etiologic factors. Family history of schizophrenia or bipolar disorder was associated with increased ASD risk across three data sets. Individuals with schizophrenic siblings were 12 times more likely to have autism compared to those with no family history of schizophrenia.
Researchers at UCLA Found that Social Skills Interventions in Teens with Autism Resulted in Significant Long-Term ImprovementsPublished June 14, 2012 in http://www.medicalnewstoday.com/releases/246528.php
Researchers at UCLA found that social skills interventions in teens with autism resulted in significant long-term improvements.
New study using eye-tracking and event-related potentials from Children’s Hospital Boston found that individuals with ASD showed atypical emotional face processing and reduced brain activation in response to emotions.
Study from Vanderbilt University uses eye-tracking and visual event-related potentials to measure attention to changing facial features in infants at high-risk for developing autism.
Study from UCSB Examines Teaching Initiations in Social Intervention Programs for School Children with AutismPublished May 29, 2012 in http://www.ncbi.nlm.nih.gov/pubmed/22645399
A new study from UC Santa Barbara found that teaching initiations in social intervention programs improved social engagement for school children with autism.
Study from University of South Australia Found that Individuals with ASD had Impairments in Face Processing and Acquiring Familiar RepresentationsPublished May 24, 2012 in http://www.ncbi.nlm.nih.gov/pubmed/22643237
A new study from the University of South Australia and the University of Cambridge found that individuals with ASD had impairments in processing faces and acquiring new face representations for familiarity.
One in three young adults with autism has no paid job experience, college, or technical schooling nearly seven years after high school graduation, a new study finds.
National Institutes of Health researchers have reversed behaviors in mice resembling two of the three core symptoms of autism spectrum disorders (ASD). An experimental compound, called GRN-529, increased social interactions and lessened repetitive self-grooming behavior in a strain of mice that normally display such autism-like behaviors, the researchers say.
Atypical Brain Activation Patterns During a Face-to-Face Joint Attention Game in Adults with Autism Spectrum Disorder.Published April 16, 2012 in Human Brain Mapping
Researchers used fMRI while participants played a joint-attention game to better understand the neural correlates of joint attention.
New Data Show Children With Autism Bullied Three Times More Frequently Than Their Unaffected SiblingsPublished March 26, 2012 in MarketWatch
Today, the Interactive Autism Network (IAN), www.ianproject.org , the nation’s largest online autism research initiative and a project of the Kennedy Krieger Institute, reports preliminary results of the first national survey to examine the impact of bullying on children with autism spectrum disorders (ASD). The results show that 63 percent of children with ASD have been bullied at some point in their lives. These children, who are sometimes intentionally “triggered” into meltdowns or aggressive outbursts by peers, are bullied three times more frequently than their siblings who do not have ASD.
Now, a new study offers insight into why some people shrug off physical touches and how families affected by autism may learn to share hugs without overwhelming an autistic childs senses.
Katherine Rice and colleagues, from the Marcus Autism Center, Children’s Healthcare of Atlanta, and Emory University School of Medicine, used eye-tracking technology to measure the relationship between cognitive and social disability in children with autism spectrum disorders (ASD) and the ability of children with ASD to pay attention to social interactions.
Children with autism spectrum disorders who also have serious behavioral problems responded better to medication combined with training for their parents than to treatment with medication alone, Yale researchers and their colleagues report in the February issue of Journal of the American Academy of Child & Adolescent Psychiatry.
Measuring brain activity in infants as young as six months may help to predict the future development of autism symptoms.
Results were released yesterday from the Pennsylvania Autism Needs Assessment, which includes feedback from 3,500 Pennsylvania caregivers and adults with autism, making it the largest study of its kind in the nation.
Children with autism spectrum disorders (ASD) tend to be fascinated by screen-based technology. A new study by a University of Missouri researcher found that adolescents with autism spend the majority of their free time using non-social media, including television and video-games.
Researchers Use Workshops To Teach Job Skills And Learn More About Families With Children On The Autism SpectrumPublished January 11, 2012 in Medical News Today
Researchers at the University of Utah have created a program that helps kids with autism focus on building their skills and utilizing an aptitude for visual-spatial thinking, computers and other electronic media.
Exploring the Social Impact of Being a Typical Peer Model for Included Children with Autism Spectrum DisorderPublished January 4, 2012 in Journal of Autism and Developmental Disorders
Peer-mediated treatments are considered best practice in improving social skills in children with ASD, but parents and school staff have voiced concerns about the social outcomes of typically developing students who serve as models for their autistic peers. This study addresses these concerns, showing that typically developing children maintain stable and positive social status after acting as peer buddies in a social skills intervention for children with ASD.
A new center at the Massachusetts Institute of Technology will focus on unraveling the neuroscience behind social behaviors, helping to push forward research and, the scientists hope, to advance diagnosis and treatment of autism spectrum disorders.
A new study suggests training peers can help children with autism spectrum disorder improve their social skills, even more than a direct adult-led intervention.
Researchers debut the SHANK2 mouse and SHANK3 rat at the 2011 Society for Neuroscience annual meeting. SHANK2 belongs to the same family as SHANK3, a well-established autism candidate gene.
UCLA researchers have found the connections between brain regions that are important for language and social skills grow much more slowly in boys with autism than in non-autistic children…
New findings from a 16-year study confirm that the Diagnostic and Statistic Manual of Mental Disorders (DSM), the gold-standard for the classification of mental health conditions, can be used to accurately identify autism spectrum disorders (ASD) in children with Down syndrome, according to research from Kennedy Krieger Institute.
A primary characteristic of autism spectrum disorders (ASD) is impairments in social-communication skills. Children and adolescents with social-communication problems face difficulty understanding, interacting and relating with others. University of Missouri researchers found that children who receive more intensive therapy to combat these impairments, especially at early ages, achieve the best outcomes.
Infants Given A Social Jump Start By Early Motor Experiences: Study Indicates Infants At Risk For Autism Could Benefit From Motor TrainingPublished September 12, 2011 in Medical News Today
In a new study published in the journal Developmental Science (Epub ahead of print), researchers from the Kennedy Krieger Institute and Vanderbilt University found that early motor experiences can shape infants’ preferences for objects and faces. The study findings demonstrate that providing infants with “sticky mittens” to manipulate toys increases their subsequent interest in faces, suggesting advanced social development. This study supports a growing body of evidence that early motor development and self-produced motor experiences contribute to infants’ understanding of the social world around them. Conversely, this implies that when motor skills are delayed or impaired – as in autism – future social interactions and development could be negatively impacted.
In a new study published today in the journal Developmental Science, researchers from the Kennedy Krieger Institute and Vanderbilt University found that early motor experiences can shape infants’ preferences for objects and faces. The study findings demonstrate that providing infants with “sticky mittens” to manipulate toys increases their subsequent interest in faces, suggesting advanced social development.This study supports a growing body of evidence that early motor development and self-produced motor experiences contribute to infants’ understanding of the social world around them. Conversely, this implies that when motor skills are delayed or impaired – as in autism – future social interactions and development could be negatively impacted.
This study estimated the ASD prevalence in a psychiatric hospital and evaluated the Social Responsiveness Scale (SRS) combined with other information for differential diagnosis. Chart review, SRS and clinical interviews were collected for 141 patients at one hospital. Diagnosis was determined at case conference. Receiver operating characteristic (ROC) curves were used to evaluate the SRS as a screening instrument. Chi-squared Automatic Interaction Detector (CHAID) analysis estimated the role of other variables, in combination with the SRS, in separating cases and non-cases. Ten percent of the sample had ASD. More than other patients, their onset was prior to 12 years of age, they had gait problems and intellectual disability, and were less likely to have a history of criminal involvement or substance abuse. Sensitivity (0.86) and specificity (0.60) of the SRS were maximized at a score of 84. Adding age of onset
In a study published this week in the Journal of Neuroscience, a team of scientists from the University’s School of Psychology show that eye contact seems to act as an invitation for mimicry, triggering mechanisms in the frontal region of the brain that control imitation. The results could be the first clues to understanding why some people, such as children with autism, struggle to grasp when they are expected to copy the actions of others in social situations.
Review from Yale examines the role of biological motion processing in autism.
Researchers at UCLA used fMRI to examine the neural mechanisms involved in social interactions in autism spectrum disorders in order to provide insight into the social attention impairments that characterize the disorder. Researchers examined children and adolescents with ASD with social and nonsocial cues. Data revealed that in typically developing individuals, there was greater responsiveness […]
Researchers at the Center for Translational Social Neuroscience (CTSN) at Emory University are focusing on prairie voles as a new model to screen the effectiveness of drugs to treat autism. They are starting with D-cycloserine, a drug Emory researchers have shown enhances behavioral therapy for phobias and also promotes pair bonding among prairie voles. Giving female voles D-cycloserine, which is thought to facilitate learning and memory, can encourage them to bond with a new male more quickly than usual.
With the help of two sets of brothers with autism, Johns Hopkins scientists have identified a gene associated with autism that appears to be linked very specifically to the severity of social interaction deficits. The gene, GRIP1 (glutamate receptor interacting protein 1), is a blueprint for a traffic-directing protein at synapses — those specialized contact points between brain cells across which chemical signals flow.
Krishnaswami et al. Researchers at Vanderbilt University found that secretin, a medical treatment for autism spectrum disorders (ASDs) that was popularized in the 1990s, is ineffective in the treatment of ASDs. Evidence from seven randomized controlled trials suggests that secretin does not effectively treat the symptoms of ASDs, which include language and communication impairment, symptom […]
Children suffering from extreme social anxiety are trapped in a nightmare of misinterpreted facial expressions: They confuse angry faces with sad ones, a new study shows.
Toddlers who played with a limited number of toys showed more improvement in their communication skills following parent-guided treatment than those receiving other community-based treatments.
Simulated interactions in which adults with autism converse with a virtual partner may help them develop better social interaction skills, according to a novel study presented in Cyberpsychology, Behavior, and Social Networking, a peer-reviewed journal published by Mary Ann Liebert, Inc.
Children with autism spectrum disorders are better able to recognize faces, facial expressions and emotions with the help of an interactive computer program called FaceSay, according to newly published research from psychologists at the University of Alabama at Birmingham.
Currently, the neurological basis of autism spectrum disorders (ASDs) is poorly understood. “Shank3 is a postsynaptic protein, whose disruption at the genetic level is thought to be responsible for the development of 22q13 deletion syndrome (Phelan-McDermid syndrome) and other non-syndromic ASDs”. In this study, mice with the Shank3 deletion were seen to exhibit “self-injurious repetitive […]
Georgianna Gould, Ph.D., research assistant professor of physiology in the Graduate School of Biomedical Sciences, is eyeing the role that serotonin plays in autism spectrum disorders. Serotonin is known for giving a sense of well-being and happiness. It is a neurotransmitter, a chemical that acts like a radio tower in the brain conveying signals among cells called neurons. Thirty percent of autism cases may have a serotonin component. In a recent paper in the Journal of Neurochemistry, Dr. Gould and colleagues showed that a medication called buspirone improved the social behaviors of mice. Buspirone is approved by the U.S. Food and Drug Administration for use in adults as an anti-anxiety and antidepressant adjuvant medication.
Touchstone Behavioral Health, a Phoenix-based treatment center that specializes in working with children has developed a virtual program that gives patients remote access to specialized autism treatment tools and allows therapists and patients to continue developing real-world life skills outside of traditional clinical environments.
A study from MIT neuroscientists reveals that high-functioning autistic adults appear to have trouble using theory of mind to make moral judgments in certain situations. Specifically, the researchers found that autistic adults were more likely than non-autistic subjects to blame someone for accidentally causing harm to another person. This shows that their judgments rely more on the outcome of the incident than on an understanding of the person’s intentions, says Liane Young, an MIT postdoctoral associate and one of the lead authors of the study.
Intervention Targeting Development of Socially Synchronous Engagement in Toddlers with Autism Spectrum Disorder: A Randomized Controlled TrialPublished January 1, 2011 in Journal of Child Psychology and Psychiatry
Two-year-olds with ASD showed improved social skills after completing an intervention targeting core social deficits in autism. It is the first randomized controlled trial to test such an intervention in toddlers and gives promise that a supplementary curriculum could improve social and communication skills in very young children. The researchers randomly assigned 50 toddlers with […]
Targeting the core social deficits of autism spectrum disorders (ASD) in early intervention programs yielded sustained improvements in social and communication skills even in very young children who have ASD, according to a study funded by the National Institute of Mental Health (NIMH), part of the National Institutes of Health.
Eastern Virginia Medical School researchers have identified a potential novel treatment strategy for the social impairment of people with Autism Spectrum Disorders (ASD), an aspect of the condition that has a profound impact on quality of life.
A post-mortem investigation measuring features of the different axons traveling beneath the cortical surface. The crux of the study is whether in autism there are changes in axons, "which are the conduit for neural communication." In comparison to control samples, autism brain tissue had fewer large axons connecting regions of the prefrontal cortex to the […]
As the number of children diagnosed with autism spectrum disorders continues to increase, the one thing that won't change is the need for those children to develop social skills. Now, researchers at the University of Missouri are developing an effective social competence curriculum, with a virtual classroom component, that could help educators meet the demand […]
Researchers from the California Institute of Technology (Caltech) have isolated a very specific difference in how high-functioning people with autism think about other people, finding that – in actuality – they don’t tend to think about what others think of them at all.
Parents of children with fragile X syndrome report that minocycline led to positive improvements in language, attention levels and behavior. They also report experiencing adverse side effects such as mild gastrointestinal issues and some increased irritability.
Kennedy Krieger Institute have announced new study results showing an early marker for later communication and social delays in infants at a higher-risk for autism may be infrequent gazing at other people when unprompted. The study also found that six-month-old high-risk infants demonstrated the same level of cause and effect learning skills when compared to low-risk infants of the same age.
People with Williams syndrome-known for their indiscriminate friendliness and ease with strangers-process spoken language differently from people with autism spectrum disorders-characterized by social withdrawal and isolation-found researchers at the Salk Institute for Biological Studies.
Training parents to adapt communication to their child’s impairments doesn’t affect the child’s autism but does help the parent-child relationship, U.K. researchers find. The idea was that training parents to respond to their child’s specific communication needs would jump-start the child’s social development and improve the child’s general communication skills.
Neuroscientists believe this “mirroring” is the mechanism by which we can “read” the minds of others and empathize with them. It’s how we “feel” someone’s pain, how we discern a grimace from a grin, a smirk from a smile. Problem was, there was no proof that mirror neurons existed — only suspicion and indirect evidence. Dr. Itzhak Fried, a UCLA professor of neurosurgery and of psychiatry and biobehavioral sciences, Roy Mukamel, a postdoctoral fellow in Fried’s lab, and their colleagues have for the first time made a direct recording of mirror neurons in the human brain.It’s suspected that dysfunction of these mirror cells might be involved in disorders such as autism, where the clinical signs can include difficulties with verbal and nonverbal communication, imitation and having empathy for others. So gaining a better understanding of the mirror neuron system might help devise strategies for treatment of this disorder.
Results of a randomized clinical trial found an innovative multi-component summer social development program to be effective in improving the social performance of children with high-functioning autism spectrum disorders.
Autism is a disease characterized by difficulties in communicating effectively with other people and developing social relationships. A team led by Angela Sirigu at the Centre de Neuroscience Cognitive (CNRS) has shown that the inhalation of oxytocin, a hormone known to promote mother-infant bonds and social relationships, significantly improved the abilities of autistic patients to interact with other individuals.
Putting a human face on a cartoon train, bus or tram proved to help children with autism understand emotions. The head of the University of Cambridge’s Autism Research Centre, Simon Baron-Cohen, conducted a study using a series of 15 animated stories called The Transporters. Each episode focused on a different emotion – from simple ones such as happy, sad and angry to more complex emotions such as sorry, ashamed, tired and joking. The findings showed children with autism spectrum conditions had improved emotion recognition after watching the 3D program for 15 minutes a day over a month.
Disgruntled mother writes about her frustrations with the use of the phrase “Those Kids” by community members to describe autistic children like her son.
Scientists at the University of Cambridge have discovered that the brains of individuals with autism are less active when engaged in self-reflective thought. The study published in the journal Brain provides new evidence for the neural correlates of self-awareness and a new window into understanding social difficulties in autism spectrum conditions.
Researchers at Children’s Hospital Boston studying the science of how babies read facial expressions say they’re hoping their results will prove useful for autism and developmental research. Scientists at Harvard believe emotion detection is so crucial in everyday life that they’re willing to cajole babies into an electrode “net” to see how to see how humans first learn to read faces.
A novel early intervention program for very young children with autism — some as young as 18 months — is effective for improving IQ, language ability and social interaction, a comprehensive new study has found.
Typically developing human infants preferentially attend to biological motion within the first days of life. This ability is highly conserved across species and is believed to be critical for filial attachment and for detection of predators. The neural underpinnings of biological motion perception are overlapping with brain regions involved in perception of basic social signals […]
Absence of Preferential Looking to the Eyes of Approaching Adults Predicts Level of Social Disability in 2-year old toddlers with Autism Spectrum DisorderPublished August 31, 2008 in Archives of General Psychiatry, Jones, Carr, et al
Looking at the eyes of others is important in early social development and in social adaptation throughout one’s life span. Our results indicate that in 2-year-old children with autism, this behavior is already derailed, suggesting critical consequences for development but also offering a potential biomarker for quantifying syndrome manifestation at this early age.
One proposed cause of ASD is exposure of the fetal brain to maternal autoantibodies during pregnancy [Dalton, P., Deacon, R., Blamire, A., Pike, M., McKinlay, I., Stein, J., Styles, P., Vincent, A., 2003. Maternal neuronal antibodies associated with autism and a language disorder. Ann. Neurol. 53, 533-537]. To provide evidence for this hypothesis, four rhesus […]