Research by Topic: social

Meta-analysis of parent-mediated interventions for young children with autism spectrum disorder

Published June 26, 2019 in Autism

A number of studies of parent-mediated interventions in autism spectrum disorder have been published in the last 15 years. We reviewed 19 randomized clinical trials of parent-mediated interventions for children with autism spectrum disorder between the ages of 1 and 6 years and conducted a meta-analysis on their efficacy. Meta-analysis outcomes were autism spectrum disorder symptom severity, […]

https://journals.sagepub.com/doi/10.1177/1362361316677838

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Social deficits in Shank3-deficient mouse models of autism are rescued by histone deacetylase (HDAC) inhibition

Published June 26, 2019

Haploinsufficiency of the SHANK3 gene is causally linked to autism spectrum disorder (ASD), and ASD-associated genes are also enriched for chromatin remodelers. Here we found that brief treatment with romidepsin, a highly potent class I histone deacetylase (HDAC) inhibitor, alleviated social deficits in Shank3-deficient mice, which persisted for ~3 weeks. HDAC2 transcription was upregulated in […]

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Study of How We Look at Faces May Offer Insight Into Autism

Published July 18, 2017

How we look at other people’s faces is strongly influenced by our genes, scientists have found in new research that may be especially important for understanding autism because it suggests that people are born with neurological differences that affect how they develop socially.  Read more here:  https://www.nytimes.com/2017/07/12/health/autism-faces-genes-brain-development.html

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Studies of the social-communication domain help clinicians understand autism vs. ADHD

Published January 25, 2016

After the domains of social and communication were merged together under ‘social communication’ in the DSM5, understanding what makes up these symptoms is more important than ever. Researchers from Center for Autism and the Developing Brain and UCSF drilled down to distinguish different types of social communication and which were most specific to autism. Using […]

http://asfpodcast.org/?p=139

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