Research by Topic: Testosterone

Podcast: What is true for males is not true for females

Published February 26, 2018

On this week’s podcast, Dr. Alycia Halladay focuses in on the Extreme Male Brain Theory of Autism. Amazingly, fetal testosterone levels are reflected in the length of the 2nd and 4th fingers and can be measured as a reflection of testosterone levels during pregnancy. But what may be true for one sex, may not be […]

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Sex Differences in Autism Spectrum Disorders

Published February 13, 2013 in Current Opinion in Neurology

A review of current research shows that ASD affects females less frequently than males and suggests this difference may be due to several sex-differential genetic and hormonal factors.

http://www.ncbi.nlm.nih.gov/pubmed/23406909

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Prenatal Versus Postnatal Sex Steroid Hormone Effects on Autistic Traits in Children at 18 to 24 Months of Age

Published December 11, 2012 in Molecular Autism

Cambridge researchers are investigating the link between pre- and postnatal hormone levels and autistic traits later in life.

http://www.molecularautism.com/content/pdf/2040-2392-3-17.pdf

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Researchers Reveal First Autism Candidate Gene That Demonstrates Sensitivity to Sex Hormones

Published March 1, 2011 in Journal of Molecular Psychiatry, Hu et al.

George Washington University researchers have found that male and female sex hormones regulate expression of an important gene in neuronal cell culture through a mechanism that could explain not only higher levels of testosterone observed in some individuals with autism, but also why males have a higher incidence of autism than females. The gene, RORA, […]

http://www.sciencedaily.com/releases/2011/02/110216185402.htm

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Researchers Reveal First Autism Candidate Gene That Demonstrates Sensitivity to Sex Hormones

Published February 17, 2011 in Science Daily

George Washington University researcher, Dr. Valerie Hu, Professor of Biochemistry and Molecular Biology, and her team at the School of Medicine and Health Sciences, have found that male and female sex hormones regulate expression of an important gene in neuronal cell culture through a mechanism that could explain not only higher levels of testosterone observed in some individuals with autism, but also why males have a higher incidence of autism than females.

http://www.sciencedaily.com/releases/2011/02/110216185402.htm

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Linkage, Association, and Gene Expression Analyses Identify CNTNAP2 as an Autism-Susceptibility Gene

Published January 1, 2008 in American Journal of Human Genetics, Alarcon, Abrahams, et al.

Autism is a genetically complex neurodevelopmental syndrome in which language deficits are a core feature. We describe results from two complimentary approaches used to identify risk variants on chromosome 7 that likely contribute to the etiology of autism. A two-stage association study tested 2758 SNPs across a 10 Mb 7q35 language-related autism QTL in AGRE […]

http://www.ncbi.nlm.nih.gov/pubmed/18179893

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