2013 Research Findings

The following studies co-authored by ASF grantees, whose names are underlined, were published in 2013. The grants awarded by ASF to fund these studies may have been distributed in years prior to 2013.

Biology

A protocol for evaluation of Rett Syndrome symptom improvement by metabolic modulators in Mecp2-mutant mice
Buchovecky CM, Hill MG, Borkey JM, Kyle SM, Justice MJ
PubMed ID: 25506514
ASF supported this research through a Pre-Doctoral Training Award to Christie Buchovecky.

A suppressor screen in Mecp2 mutant mice implicates cholesterol metabolism in Rett syndrome
Buchovecky CM, Turley SD, Brown HM, Kyle SM, McDonald JG, Liu B, Pieper AA, Huang W, Katz DM, Russell DW, Shendure J, Justice MJ
PubMed ID: 23892605
ASF supported this research through a Pre-Doctoral Training Award to Christie Buchovecky.

Astroglial FMRP-dependent translational down-regulation of mGluR5 underlies glutamate transporter GLT1 dysregulation in the fragile X mouse
Higashimori H, Morel L, Huth J, Lindemann L, Dulla C, Taylor A, Freeman M, Yang Y
PubMed ID: 23396537
ASF supported this research through a Post-Doctoral Training Award to Haruki Higashimori.

Loss of predominant Shank3 isoforms results in hippocampus-dependent impairments in behavior and synaptic transmission
Kouser M, Speed HE, Dewey CM, Reimers JM, Widman AJ, Gupta N, Liu S, Jaramillo TC, Bangash M, Xiao B, Worley PF, Powell CM
PubMed ID: 24259569
ASF supported this research through a Post-Doctoral Training Award to Haley Speed.

SHANK3 and IGF1 restore synaptic deficits in neurons from 22q13 deletion syndrome patients
Shcheglovitov A, Shcheglovitova O, Yazawa M, Portmann T, Shu R, Sebastiano V, Krawisz A, Froehlich W, Bernstein JA, Hallmayer JF, Dolmetsch RE
PubMed ID: 24132240
ASF supported this research through a Post-Doctoral Training Award to Oleksandr Shcheglovitov.

Diagnosis

Frequency and pattern of documented diagnostic features and the age of autism identification
Maenner MJ, Schieve LA, Rice CE, Cunniff C, Giarelli E, Kirby RS, Lee LC, Nicholas JS, Wingate MS, Durkin MS
PubMed ID: 23582871
ASF supported this research through a Fellowship Award to Matthew Maenner.

The Early Motor Questionnaire (EMQ): a parental report measure of early motor development
Libertus K, Landa RJ
PubMed ID: 24140841
ASF supported this research through a Post-Doctoral Training Award to Klaus Libertus.

Treatment

Comparing spoken language treatments for minimally verbal preschoolers with autism spectrum disorders
Paul R, Campbell D, Gilbert K, Tsiouri I
PubMed ID: 22733301
ASF supported this research through a Fellowship Award to Sarita Austin, whose work was used in this study.