2016 Research Findings

The following studies co-authored by ASF grantees, whose names are underlined, were published in 2016. The grants awarded by ASF to fund these studies may have been distributed in years prior to 2016.

Biology

A Mouse Model of X-linked Intellectual Disability Associated with Impaired Removal of Histone Methylation
Iwase S, Brookes E, Agarwal S, Badeaux AI, Ito H, Vallianatos CN, Tomassy GS, Kasza T, Lin G, Thompson A, Gu L, Kwan KY, Chen C, Sartor MA, Egan B, Xu J, Shi Y
PubMed ID: 26804915
ASF supported this research through a Post-Doctoral Training Award to Aimee Iberg Badeaux.

A role for the endocannabinoid 2-arachidonoyl-sn-glycerol for social and high-fat food reward in male mice
Wei D, Lee D, Li D, Daglian J, Jung KM, Piomelli D
PubMed ID: 26873082
ASF supported this research through a Pre-Doctoral Training Award to Donghui Wei.

A Systematic Review and Meta-Analysis of Multiple Airborne Pollutants and Autism Spectrum Disorder
Lam J, Sutton P, Kalkbrenner A, Windham G, Halladay A, Koustas E, Lawler C, Davidson L, Daniels N, Newschaffer C, Woodruff T
PubMed ID: 27653281
ASF Chief Science Officer Alycia Halladay co-authored this publication.

Altered mGluR5-Homer scaffolds and corticostriatal connectivity in a Shank3 complete knockout model of autism
Wang X, Bey AL, Katz BM, Badea A, Kim N, David LK, Duffney LJ, Kumar S, Mague SD, Hulbert SW, Dutta N, Hayrapetyan V, Yu C, Gaidis E, Zhao S, Ding JD, Xu Q, Chung L, Rodriguiz RM, Wang F, Weinberg RJ, Wetsel WC, Dzirasa K, Yin H, Jiang YH
PubMed ID: 27161151
ASF supported this research through a Pre-Doctoral Training Award to Alexandra Bey.

Altered Placental Tryptophan Metabolism: A Crucial Molecular Pathway for the Fetal Programming of Neurodevelopmental Disorders
Bonnin A, Goeden N, Lund B, Anderson G
Publication Link: Defense Technical Information Center
ASF supported this research through a Pre-Doctoral Training Award to Nick Goeden.

Altered Striatal Synaptic Function and Abnormal Behaviour in Shank3 Exon4-9 Deletion Mouse Model of Autism
Jaramillo TC, Speed HE, Xuan Z, Reimers JM, Liu S, Powell CM
PubMed ID: 26559786
ASF supported this research through a Post-Doctoral Training Award to Haley Speed.

Direct modulation of GFAP-expressing glia in the arcuate nucleus bi-directionally regulates feeding
Chen N, Sugihara H, Kim J, Fu Z, Barak B, Sur M, Feng G, Han W
PubMed ID: 27751234
ASF supported this research through a Post-Doctoral Training Award to Boaz Barak.

Enhancement of Anandamide-Mediated Endocannabinoid Signaling Corrects Autism-Related Social Impairment
Wei D, Dinh D, Lee D, Li D, Anguren A, Moreno-Sanz G, Gall CM, Piomelli D
PubMed ID: 28861483
ASF supported this research through a Pre-Doctoral Training Award to Donghui Wei.

Epigenetic Research in Neuropsychiatric Disorders: the “Tissue Issue”
Bakulski KM, Halladay A, Hu VW, Mill J, Fallin MD
PubMed ID: 28093577
ASF Chief Science Officer Alycia Halladay co-authored this publication.

Frequency and Complexity of De Novo Structural Mutation in Autism
Brandler WM, Antaki D, Gujral M, Noor A, Rosanio G, Chapman TR, Barrera DJ, Lin GN, Malhotra D, Watts AC, Wong LC, Estabillo JA, Gadomski TE, Hong O, Fajardo KV, Bhandari A, Owen R, Baughn M, Yuan J, Solomon T, Moyzis AG, Maile MS, Sanders SJ, Reiner GE, Vaux KK, Strom CM, Zhang K, Muotri AR, Akshoomoff N, Leal SM, Pierce K, Courchesne E, Iakoucheva LM, Corsello C, Sebat J
PubMed ID: 27018473
ASF supported this research through a Post-Doctoral Training Award to William Brandler.

Maternal Inflammation Disrupts Fetal Neurodevelopment via Increased Placental Output of Serotonin to the Fetal Brain
Goeden N, Velasquez J, Arnold KA, Chan Y, Lund BT, Anderson GM, Bonnin A
PubMed ID: 27251625
ASF supported this research through a Pre-Doctoral Training Award to Nick Goeden.

Maternal Loss of Ube3a Impairs Experience-Driven Dendritic Spine Maintenance in the Developing Visual Cortex
Kim H, Kunz PA, Mooney R, Philpot BD, Smith SL
PubMed ID: 27122043
ASF supported this research through a Post-Doctoral Training Award to Portia Kunz-Smith.

Mice with Shank3 Mutations Associated with ASD and Schizophrenia Display Both Shared and Distinct Defects
Zhou Y, Kaiser T, Monteiro P, Zhang X, Van der Goes MS, Wang D, Barak B, Zeng M, Li C, Lu C, Wells M, Amaya A, Nguyen S, Lewis M, Sanjana N, Zhou Y, Zhang M, Zhang F, Fu Z, Feng G
PubMed ID: 26687841
ASF supported this research through a Post-Doctoral Training Award to Boaz Barak.

Mice with Shank3 Mutations Associated with ASD and Schizophrenia Display Both Shared and Distinct Defects
Zhou Y, Kaiser T, Monteiro P, Zhang X, Van der Goes MS, Wang D, Barak B, Zeng M, Li C, Lu C, Wells M, Amaya A, Nguyen S, Lewis M, Sanjana N, Zhou Y, Zhang M, Zhang F, Fu Z, Feng G
PubMed ID: 26687841
ASF supported this research through a Post-Doctoral Training Award to Boaz Barak.

Neurobiology of social behavior abnormalities in autism and Williams syndrome
Barak B, Feng G
PubMed ID: 29323671
ASF supported this research through a Post-Doctoral Training Award to Boaz Barak.

Project TENDR: Targeting Environmental Neuro-Developmental Risks The TENDR Consensus Statement
Bennett D, Bellinger DC, Birnbaum LS, Bradman A, Chen A, Cory-Slechta DA, Engel SM, Fallin MD, Halladay A, Hauser R, Hertz-Picciotto I, Kwiatkowski CF, Lanphear BP, Marquez E, Marty M, McPartland J, Newschaffer CJ, Payne-Sturges D, Patisaul HB, Perera FP, Ritz B, Sass J, Schantz SL, Webster TF, Whyatt RM, Woodruff TJ, Zoeller RT, Anderko L, Campbell C, Conry JA, DeNicola N, Gould RM, Hirtz D, Huffling K, Landrigan PJ, Lavin A, Miller M, Mitchell MA, Rubin L, Schettler T, Tran HL, Acosta A, Brody C, Miller E, Miller P, Swanson M, Witherspoon NO; American College of Obstetricians and Gynecologists (ACOG); Child Neurology Society; Endocrine Society; International Neurotoxicology Association; International Society for Children’s Health and the Environment; International Society for Environmental Epidemiology; National Council of Asian Pacific Islander Physicians; National Hispanic Medical Association; National Medical Association
PubMed ID: 27479987
ASF Chief Science Officer Alycia Halladay co-authored this publication.

Selective Deletion of Astroglial FMRP Dysregulates Glutamate Transporter GLT1 and Contributes to Fragile X Syndrome Phenotypes In Vivo
Higashimori H, Schin CS, Chiang MS, Morel L, Shoneye TA, Nelson DL, Yang Y
PubMed ID: 27383586
ASF supported this research through a Post-Doctoral Training Award to Haruki Higashimori.

Serotonin 1A agonism decreases affiliative behavior in pair-bonded titi monkeys
Larke RH, Maninger N, Ragen BJ, Mendoza SP, Bales KL
PubMed ID: 27712925
ASF supported this research through a Pre-Doctoral Training Award to Rebecca Larke.

The role of sex-differential biology in risk for autism spectrum disorder
Werling DM
PubMed ID: 27891212
ASF supported this research through a Post-Doctoral Training Award to Donna Werling.

Psychology

Altered tactile processing in children with autism spectrum disorder
Tavassoli T, Bellesheim K, Tommerdahl M, Holden JM, Kolevzon A, Buxbaum JD
PubMed ID: 26568449
ASF supported this research through a Post-Doctoral Training Award to Teresa Tavassoli.

Brain responses to biological motion predict treatment outcome in young children with autism
Yang D, Pelphrey KA, Sukhodolsky DG, Crowley MJ, Dayan E, Dvornek NC, Venkataraman A, Duncan J, Staib L, Ventola P
PubMed ID: 27845779
ASF supported this research through an Enhancement Mini-Grant to Pamela Ventola.

Exploring Autism Spectrum Disorders Using HLT
Parish-Morris J, Liberman M, Ryant N, Cieri C, Bateman L, Ferguson M, Schultz RT
Publication Link: Association of Computational Linguistics
ASF supported this research through a Post-Doctoral Training Award to Julia Parish-Morris.

Maturation of auditory neural processes in autism spectrum disorder – A longitudinal MEG study
Port RG, Edgar JC, Ku M, Bloy L, Murray R, Blaskey L, Levy SE, Roberts TPL
PubMed ID: 27158589
ASF supported this research through a Pre-Doctoral Training Award to Russell Port.

Neural Connectivity Evidence for a Categorical-Dimensional Hybrid Model of Autism Spectrum Disorder
Elton A, Di Martino A, Hazlett HC, Gao W
PubMed ID: 26707088
ASF provide funding support to the Autism Brain Imaging Data Exchange.

Prospective Longitudinal Studies of Infant Siblings of Children With Autism: Lessons Learned and Future Directions
Szatmari P, Chawarska K, Dawson G, Georgiades S, Landa R, Lord C, Messinger DS, Thurm A, Halladay A
PubMed ID: 26903251
ASF Chief Science Officer Alycia Halladay co-authored this publication.

Reduced engagement with social stimuli in 6-month-old infants with later autism spectrum disorder: a longitudinal prospective study of infants at high familial risk
Jones EJ, Venema K, Earl R, Lowy R, Barnes K, Estes A, Dawson G, Webb SJ
PubMed ID: 26981158
ASF supported this research through a Fellowship Award to Karen Barnes.

Relations between language and cognition in native-signing children with autism spectrum disorder
Shield A, Pyers J, Martin A, Tager-Flusberg H
PubMed ID: 26938935
ASF supported this research through an Enhancement Mini-Grant to Aaron Shield.

Revealing the world of autism through the lens of a camera
Wang S, Fan S, Chen B, Hakimi S, Paul LK, Zhao Q, Adolphs R
PubMed ID: 27780054
ASF supported this research through a Post-Doctoral Training Award to Shuo Wang.

Diagnosis

Brief Report: Sensory Reactivity in Children with Phelan-McDermid Syndrome
Mieses AM, Tavassoli T, Li E, Soorya L, Lurie S, Wang AT, Siper PM, Kolevzon A
PubMed ID: 26914612
ASF supported this research through a Post-Doctoral Training Award to Teresa Tavassoli and a Treatment Grant to Alexander Kolevzon.

Measuring Sensory Reactivity in Autism Spectrum Disorder: Application and Simplification of a Clinician-Administered Sensory Observation Scale
Tavassoli T, Bellesheim K, Siper PM, Wang AT, Halpern D, Gorenstein M, Grodberg D, Kolevzon A, Buxbaum JD
PubMed ID: 26340959
ASF supported this research through a Post-Doctoral Training Award to Teresa Tavassoli.

Parent and Teacher Concordance on the Social Responsiveness Scale for Children with Autism
Azad G, Reisinger E, Xie M, Mandell DS
PubMed ID: 27617039
ASF supported this research through an Enhancement Mini-Grant to Gazi Azad.

Re-conceptualizing ASD Within a Dimensional Framework: Positive, Negative, and Cognitive Feature Clusters
Foss-Feig JH, McPartland JC, Anticevic A, Wolf J
PubMed ID: 26267330
ASF supported this research through an Accelerator Award to Jennifer Foss-Feig.

The Differential Diagnosis of Anxiety Disorders in Cognitively-Able Youth With Autism
Kerns CM, Rump K, Worley J, Kratz H, McVey A, Herrington J, Miller J
DOI: 10.1016/j.cbpra.2015.11.004
ASF supported this research through an Enhancement Mini-Grant to Connor Kerns.

Treatment

Brief Report: Reduced Restricted and Repetitive Behaviors after Pivotal Response Treatment
Ventola PE, Yang D, Abdullahi SM, Paisley CA, Braconnier ML, Sukhodolsky DG
PubMed ID: 27230762
ASF supported this research through an Enhancement Mini-Grant to Pamela Ventola.

Pivotal response treatment prompts a functional rewiring of the brain among individuals with autism spectrum disorder
Venkataraman A, Yang DY, Dvornek N, Staib LH, Duncan JS, Pelphrey KA, Ventola P
PubMed ID: 27532879
ASF supported this research through an Enhancement Mini-Grant to Pamela Ventola.

Services

A systematic review of peer-mediated interventions for children with autism spectrum disorder
Chang YC, Locke J
PubMed ID: 27807466
ASF supported this research through an Early Career Award to Jill Locke.

Building Language Resources for Exploring Autism Spectrum Disorders
Parish-Morris J, Cieri C, Liberman M, Bateman L, Ferguson E, Schultz RT
PubMed ID: 30167575
ASF supported this research through a Post-Doctoral Training Award to Julia Parish-Morris.

Concerns of parents and teachers of children with autism in elementary school
Azad G, Mandell DS
PubMed ID: 26069200
ASF supported this research through an Enhancement Mini-Grant to Gazi Azad.

Decline in Medicaid-Funded One-to-One Behavioral Support Use in School as Children Age
Kang-Yi CD, Locke J, Pellecchia M, Marcus SC, Hadley T, Mandell DS
PubMed ID: 27818714
ASF supported this research through an Early Career Award to Jill Locke.

Examining playground engagement between elementary school children with and without autism spectrum disorder
Locke J, Shih W, Kretzmann M, Kasari C
PubMed ID: 26341991
ASF supported this research through an Early Career Award to Jill Locke.

Parent-Teacher Communication about Children with Autism Spectrum Disorder: An Examination of Collaborative Problem-Solving
Azad GF, Kim M, Marcus SC, Mandell DS, Sheridan SM
PubMed ID: 28392604
ASF supported this research through an Enhancement Mini-Grant to Gazi Azad.

School-Based Behavioral Health Service Use and Expenditures for Children With Autism and Children With Other Disorders
Kang-Yi CD, Locke J, Marcus SC, Hadley TR, Mandell DS
PubMed ID: 26278232
ASF supported this research through an Early Career Award to Jill Locke.

Social network analysis of children with autism spectrum disorder: Predictors of fragmentation and connectivity in elementary school classrooms
Anderson A, Locke J, Kretzmann M, Kasari C; AIR-B Network
PubMed ID: 26567264
ASF supported this research through an Early Career Award to Jill Locke.