2017 Research Findings

The following studies co-authored by ASF grantees, whose names are underlined, were published in 2017. The grants awarded by ASF to fund these studies may have been distributed in years prior to 2017.

Biology

Deficiency of Shank2 causes mania-like behavior that responds to mood stabilizers
Pappas AL, Bey AL, Wang X, Rossi M, Kim YH, Yan H, Porkka F, Duffney LJ, Phillips SM, Cao X, Ding JD, Rodriguiz RM, Yin HH, Weinberg RJ, Ji RR, Wetsel WC, Jiang YH
PubMed ID: 29046483
ASF supported this research through a Pre-Doctoral Training Award to Alexandra Bey.

denovo-db: a compendium of human de novo variants
Turner TN, Yi Q, Krumm N, Huddleston J, Hoekzema K, F Stessman HA, Doebley AL, Bernier RA, Nickerson DA, Eichler EE
PubMed ID: 27907889
ASF supported this research through a Post-Doctoral Training Award to Tychele Turner.

Endocannabinoid Signaling in the Control of Social Behavior
Wei D, Allsop S, Tye K, Piomelli D
PubMed ID: 28554687
ASF supported this research through a Pre-Doctoral Training Award to Donghui Wei.

Exploring the relationship between cortical GABA concentrations, auditory gamma-band responses and development in ASD: Evidence for an altered maturational trajectory in ASD
Usui N, Araujo DJ, Kulkarni A, Co M, Ellegood J, Harper M, Toriumi K, Lerch JP, Konopka G
PubMed ID: 27696740
ASF supported this research through a Pre-Doctoral Training Award to Russell Port.

Foxp1 regulation of neonatal vocalizations via cortical development
Port RG, Gaetz W, Bloy L, Wang DJ, Blaskey L, Kuschner ES, Levy SE, Brodkin ES, Roberts TPL
PubMed ID: 29138280
ASF supported this research through a Pre-Doctoral Training Award to Marissa Co.

Genomic Patterns of De Novo Mutation in Simplex Autism
Turner TN, Coe BP, Dickel DE, Hoekzema K, Nelson BJ, Zody MC, Kronenberg ZN, Hormozdiari F, Raja A, Pennacchio LA, Darnell RB, Eichler EE
PubMed ID: 28965761
ASF supported this research through a Post-Doctoral Training Award to Tychele Turner.

Hotspots of missense mutation identify novel neurodevelopmental disorder genes and functional domains
Geisheker MR, Heymann G, Wang T, Coe BP, Turner TN, Stessman HAF, Hoekzema K, Kvarnung M, Shaw M, Friend K, Liebelt J, Barnett C, Thompson EM, Haan E, Guo H, Anderlid BM, Nordgren A, Lindstrand A, Vandeweyer G, Alberti A, Avola E, Vinci M, Giusto S, Pramparo T, Pierce K, Nalabolu S, Michaelson JJ, Sedlacek Z, Santen GWE, Peeters H, Hakonarson H, Courchesne E, Romano C, Kooy RF, Bernier R, Nordenskjöld M, Gecz J, Xia K, Zweifel LS, Eichler EE
PubMed ID: 28628100
ASF supported this research through a Post-Doctoral Training Award to Tychele Turner.

Identification of Developmental and Behavioral Markers Associated with Genetic Abnormalities in Autism Spectrum Disorder
Bishop SL, Farmer C, Bal V, Robinson EB, Willsey AJ, Werling DM, Havdahl KA, Sanders SJ, Thurm A
PubMed ID: 28253736
ASF supported this research through a Post-Doctoral Training Award to Donna Werling.

Kctd13 deletion reduces synaptic transmission via increased RhoA
Escamilla CO, Filonova I, Walker AK, Xuan ZX, Holehonner R, Espinosa F, Liu S, Thyme SB, López-García IA, Mendoza DB, Usui N, Ellegood J, Eisch AJ, Konopka G, Lerch JP, Schier AF, Speed HE, Powell CM
PubMed ID: 29088697
ASF supported this research through a Pre-Doctoral Training Award to Christine Ochoa Escamilla.

Neuronal overexpression of Ube3a isoform 2 causes behavioral impairments and neuroanatomical pathology relevant to 15q11.2-q13.3 duplication syndrome
Copping NA, Christian SGB, Ritter DJ, Islam MS, Buscher N, Zolkowska D, Pride MC, Berg EL, LaSalle JM, Ellegood J, Lerch JP, Reiter LT, Silverman JL, Dindot SV
PubMed ID: 29016856
ASF supported this research through an Undergraduate Summer Research Grant to Dylan Ritter.

Novel Shank3 Mutant Exhibits Behaviors With Face Validity for Autism and Altered Striatal and Hippocampal Function
Jarmillo TC, Speed HE, Xuan Z, Reimers JM, Escamilla CO, Weaver TP, Liu S, Filonova I, Powell CM
PubMed ID: 27492494
ASF supported this research through a Post-Doctoral Training Award to Haley Speed.

Protocadherin 10 alters γ oscillations, amino acid levels, and their coupling; baclofen partially restores these oscillatory deficits
Port RG, Gajewski C, Krizman E, Dow HC, Hirano S, Brodkin ES, Carlson GC, Robinson MB, Roberts TPL, Siegel SJ
PubMed ID: 28844789
ASF supported this research through a Pre-Doctoral Training Award to Russell Port.

Retrograde Synaptic Inhibition Is Mediated by α-Neurexin Binding to the α2δ Subunits of N-Type Calcium Channels
Tong XJ, López-Soto EJ, Li L, Liu H, Nedelcu D, Lipscombe D, Hu Z, Kaplan JM
PubMed ID: 28669545
ASF supported this research through a Post-Doctoral Training Award to Daniel Nedelcu.

Sex-specific gene–environment interactions underlying ASD-like behaviors
Schaafsma SM, Gagnidze K, Reyes A, Norstedt N, Månsson K, Francis K, Pfaff DW
PubMed ID: 28115688
ASF supported this research through a Post-Doctoral Training Award to Sara Schaafsma.

Sumoylation of FOXP2 regulates motor function and vocal communication through Purkinje cell development
Usui N, Co M, Harper M, Rieger MA, Dougherty JD, Konopka G
PubMed ID: 27009683
ASF supported this research through a Pre-Doctoral Training Award to Marissa Co.

The Number of Parvalbumin-Expressing Interneurons Is Decreased in the Prefrontal Cortex in Autism
Hashemi E, Ariza J, Rogers H, Noctor SC, Martínez-Cerdeño V
PubMed ID: 26922658
ASF supported this research through a Pre-Doctoral Training Award to Ezzat Hashemi.

Psychology

Audition-Specific Temporal Processing Deficits Associated with Language Function in Children with Autism Spectrum Disorder
Foss-Feig JH, Schauder KB, Key AP, Wallace MT, Stone WL
PubMed ID: 28632303
ASF supported this research through an Accelerator Award to Jennifer Foss-Feig.

Brief Report: Examining Executive and Social Functioning in Elementary-Aged Children with Autism
Freeman LM, Locke J, Rotheram-Fuller E, Mandell DS
PubMed ID: 28260182
ASF supported this research through a Post-Doctoral Training Award and an Early Career Award to Jill Locke.

Development of Attention to Faces during the First 3 Years: Influences of Stimulus Type
Libertus K, Landa RJ, Haworth JL
PubMed ID: 29204130
ASF supported this research through a Post-Doctoral Training Award to Klaus Libertus.

Distinct neural bases of disruptive behavior and autism symptom severity in boys with autism spectrum disorder
Yang YJ, Sukhodolsky DG, Lei J, Dayan E, Pelphrey KA, Ventola P
PubMed ID: 28115995
ASF supported this research through an Enhancement Mini-Grant to Pamela Ventola.

EEG power at 3 months in infants at high familial risk for autism
Levin AR, Varcin KJ, O’Leary HM, Tager-Flusberg H, Nelson CA
PubMed ID: 28903722
ASF supported this research through a Post-Doctoral Training Award to April Levin.

Exploring the Effect of Immediate Video Feedback on Coaching
Suhrheinrich J, Chan J
DOI: 10.1177/0162643416681163
ASF supported this research through an Enhancement Mini-Grant to Jessica Suhrheinrich.

High internal noise and poor external noise filtering characterize perception in autism spectrum disorder
Park WJ, Schauder KB, Zhang R, Bennetto L, Tadin D
PubMed ID: 29242499
ASF supported this research through a Pre-Doctoral Training Award to Woon Ju Park.

Impaired praxis in gesture imitation by deaf children with autism spectrum disorder
Shield A, Knapke K, Henry M, Srinivasan S, Bhat A
DOI: 10.1177/2396941517745674
ASF supported this research through an Enhancement Mini-Grant to Aaron Shield.

Linguistic camouflage in girls with autism spectrum disorder
Parish-Morris J, Liberman MY, Cieri C, Herrington JD, Yerys BE, Bateman L, Donaher J, Ferguson E, Pandey J, Schultz RT
PubMed ID: 29021889
ASF supported this research through a Post-Doctoral Training Award to Julia Parish-Morris.

Mechanisms of Diminished Attention to Eyes in Autism
Moriuchi JM, Klin A, Jones W
PubMed ID: 27855484
ASF supported this research through a Pre-Doctoral Training Award to Jennifer Moriuchi.

Parenting a Child with ASD: Comparison of Parenting Style Between ASD, Anxiety, and Typical Development
Ventola P, Lei J, Paisley C, Lebowitz E, Silverman W
PubMed ID: 28634706
ASF supported this research through an Enhancement Mini-Grant to Pamela Ventola.

Race, disability, and grade: Social relationships in children with autism spectrum disorders
Azad GF, Locke J, Kasari C, Mandell DS
PubMed ID: 26966285
ASF supported this research through an Enhancement Mini-Grant to Gazi Azad and an Early Career Award to Jill Locke.

Reduced specificity in emotion judgment in people with autism spectrum disorder
Wang S, Adolphs R
PubMed ID: 28343960
ASF supported this research through a Post-Doctoral Training Award to Shuo Wang.

Searching for Cross-diagnostic Convergence: Neural Mechanisms Governing Excitation and Inhibition Balance in Schizophrenia and Autism Spectrum Disorders
Foss-Feig JH, Adkinson DB, Ji JL, Yang G, Srihari VH, McPartland JC, Krystal JH, Murray JD, Anticevic A
PubMed ID: 28434615
ASF supported this research through an Accelerator Award to Jennifer Foss-Feig.

Sign Language Echolalia in Deaf Children With Autism Spectrum Disorder
Shield A, Cooley F, Meier RP
PubMed ID: 28586822
ASF supported this research through an Enhancement Mini-Grant to Aaron Shield.

The clinician perspective on sex differences in autism spectrum disorders
Jamison R, Bishop SL, Huerta M, Halladay AK
PubMed ID: 28429618
ASF Chief Science Officer Alycia Halladay co-authored this publication.

The human amygdala parametrically encodes the intensity of specific facial emotions and their categorical ambiguity
Wang S, Yu R, Tyszka JM, Zhen S, Kovach C, Sun S, Huang Y, Hurlemann R, Ross IB, Chung JM, Mamelak AN, Adolphs R, Rutishauser U
PubMed ID: 28429707
ASF supported this research through a Post-Doctoral Training Award to Shuo Wang.

Vocalization Rate and Consonant Production in Toddlers at High and Low Risk for Autism
Chenausky K, Nelson C, Tager-Flusberg H
PubMed ID: 28384664
ASF supported this research through an Accelerator Award to Karen Chenausky.

Diagnosis

A Prospective Study of Neurological Abnormalities in Phelan-Mcdermid Syndrome
Frank Y, Jamison JM, Trelles MP, Siper PM, Tavassoli T, Soorya LVA, Lurie S, Reiger HT, Feldman E, Naidich T, Wang T, Halpern D, Buxbaum JD, Kolevzon A
Publication Link: The Journal of Rare Disorders
ASF supported this research through a Treatment Grant to Alexander Kolevzon.

Anxiety Disorders Interview Schedule-Autism Addendum: Reliability and Validity in Children With Autism Spectrum Disorder
Kerns CM, Renno P, Kendall PC, Wood JJ, Storch EA
PubMed ID: 27925775
ASF supported this research through an Accelerator Award to Connor Kerns.

Language ENvironment Analysis (LENA) in Phelan-McDermid Syndrome: Validity and Suggestions for Use in Minimally Verbal Children with Autism Spectrum Disorder
Rankine J, Li E, Lurie S, Rieger H, Fourie E, Siper PM, Wang AT, Buxbaum JD, Kolevzon A
PubMed ID: 28255759
ASF supported this research through a Treatment Grant to Alex Kolevzon.

Treatment

Attempting to “Increase Intake from the Input”: Attention and Word Learning in Children with Autism
Tenenbaum EJ, Amso D, Righi G, Sheinkopf SJ
PubMed ID: 28342164
ASF supported this research through a Post-Doctoral Training Award to Elena Tenenbaum.

Brief report: Reduced anxiety following Pivotal Response Treatment in young children with Autism Spectrum Disorder
Lei J, Sukhodolsky DG, Abdullahi SM, Bracconnier ML, Ventola P
PubMed ID: 29333196
ASF supported this research through an Enhancement Mini-Grant to Pamela Ventola.

Improving Functional Language and Social Motivation with a Parent-Mediated Intervention for Toddlers with Autism Spectrum Disorder
Bradshaw J, Koegel LK, Koegel RL
PubMed ID: 28536956
ASF supported this research through a Pre-Doctoral Training Award to Jessica Bradshaw.

Pivotal response treatment for autism spectrum disorder: current perspectives
Lei J, Ventola P
PubMed ID: 28790824
ASF supported this research through an Enhancement Mini-Grant to Pamela Ventola.

Services

Ethnic Disparities in School‐Based Behavioral Health Service Use for Children With Psychiatric Disorders
Locke J, Kang-Yi CD, Pellecchia M, Marcus S, Hadley T, Mandell DS
PubMed ID: 27917490
ASF supported this research through an Early Career Award to Jill Locke.

Pebbles, rocks, and boulders: The implementation of a school-based social engagement intervention for children with autism
Locke J, Wolk CB, Harker C, Olsen A, Shingledecker T, Barg F, Mandell D, Beidas R
PubMed ID: 28954537
ASF supported this research through an Early Career Award to Jill Locke.