2018 Research Findings

The following studies co-authored by ASF grantees, whose names are underlined, were published in 2017. The grants awarded by ASF to fund these studies may have been distributed in years prior to 2017.

Biology

An analytical framework for whole-genome sequence association studies and its implications for autism spectrum disorder
Werling DM, Brand H, An JY, Stone MR, Zhu L, Glessner JT, Collins RL, Dong S, Layer RM, Markenscoff-Papadimitriou E, Farrell A, Schwartz GB, Wang HZ, Currall BB, Zhao X, Dea J, Duhn C, Erdman CA, Gilson MC, Yadav R, Handsaker RE, Kashin S, Klei L, Mandell JD, Nowakowski TJ, Liu Y, Pochareddy S, Smith L, Walker MF, Waterman MJ, He X, Kriegstein AR, Rubenstein JL, Sestan N, McCarroll SA, Neale BM, Coon H, Willsey AJ, Buxbaum JD, Daly MJ, State MW, Quinlan AR, Marth GT, Roeder K, Devlin B, Talkowski ME, Sanders SJ
PubMed ID: 29700473
ASF supported this research through a Post-Doctoral Training Award to Donna Werling.

Altered Gene-Regulatory Function of KDM5C by a Novel Mutation Associated With Autism and Intellectual Disability
Vallianatos CN, Farrehi C, Friez MJ, Burmeister M, Keegan CE, Iwase S
PubMed ID: 29670509
ASF supported this research through a Pre-Doctoral Training Award to Christina Vallianatos.

Blocking Zika virus vertical transmission
Mesci P, Macia A, Moore SM, Shiryaev SA, Pinto A, Huang CT, Tejwani L, Fernandes IR, Suarez NA, Kolar MJ, Montefusco S, Rosenberg SC, Herai RH, Cugola FR, Russo FB, Sheets N, Saghatelian A, Shresta S, Momper JD, Siqueira-Neto JL, Corbett KD, Beltrão-Braga PCB, Terskikh AV, Muotri AR
PubMed ID: 29352135
ASF supported this research through a Pre-Doctoral Training Award to Spencer Moore.

Brain region-specific disruption of Shank3 in mice reveals a dissociation for cortical and striatal circuits in autism-related behaviors
Bey AL, Wang X, Yan H, Kim N, Pasman RL, Yang Y, Cao X, Towers AJ, Hulbert SW, Duffney LJ, Gaidis E, Rodriguiz RM, Wetsel WC, Yin HH, Jiang YH
PubMed ID: 29700290
ASF supported this research through a Pre-Doctoral Training Award to Alexandra Bey.

Brain transcriptome databases: a user’s guide
Keil JM, Qalieh A, Kwan KY
PubMed ID: 29437890
ASF supported this research through a Pre-Doctoral Training Award to Jason Keil.

Dichotomous parvalbumin interneuron populations in dorsolateral and dorsomedial striatum
Monteiro P, Barak B, Zhou Y, McRae R, Rodrigues D, Wickersham IR, Feng G
PubMed ID: 29808928
ASF supported this research through a Post-Doctoral Training Award to Boaz Barak.

Exome sequencing of 85 Williams–Beuren syndrome cases rules out coding variation as a major contributor to remaining variance in social behavior
Kopp ND, Parrish PCR, Lugo M, Dougherty JD, Kozel BA
PubMed ID: 30008175
ASF supported this research through a Pre-Doctoral Training Award to Nathan Kopp.

Gene expression in cord blood links genetic risk for neurodevelopmental disorders with maternal psychological distress and adverse childhood outcomes
Breen MS, Wingo AP, Koen N, Donald KA, Nicol M, Zar HJ, Ressler KJ, Buxbaum JD, Stein DJ
PubMed ID: 29791872
ASF supported this research through a Post-Doctoral Training Award to Michael Breen.

Genetic variations on SETD5 underlying autistic conditions
Fernandes IR, Cruz ACP, Ferrasa A, Phan D, Herai RH, Muotri AR
PubMed ID: 29484850
ASF supported this research through a Post-Doctoral Training Award to Isabella Rodrigues Fernandes.

Paternally inherited cis-regulatory structural variants are associated with autism
Brandler WM, Antaki D, Gujral M, Kleiber ML, Whitney J, Maile MS, Hong O, Chapman TR, Tan S, Tandon P, Pang T, Tang SC, Vaux KK, Yang Y, Harrington E, Juul S, Turner DJ, Thiruvahindrapuram B, Kaur G, Wang Z, Kingsmore SF, Gleeson JG, Bisson D, Kakaradov B, Telenti A, Venter JC, Corominas R, Toma C, Cormand B, Rueda I, Guijarro S, Messer KS, Nievergelt CM, Arranz MJ, Courchesne E, Pierce K, Muotri AR, Iakoucheva LM, Hervas A, Scherer SW, Corsello C, Sebat J
PubMed ID: 29674594
ASF supported this research through a Post-Doctoral Training Award to William Brandler.

Shank3 mutation in a mouse model of autism leads to changes in the S-nitroso-proteome and affects key proteins involved in vesicle release and synaptic function
Amal H, Barak B, Bhat V, Gong G, Joughin BA, Wishnok JS, Feng G, Tannenbaum SR
PubMed ID: 29988084
ASF supported this research through a Post-Doctoral Training Award to Boaz Barak.

Temporal proteomic profiling of postnatal human cortical development
Breen MS, Ozcan S, Ramsey JM, Wang Z, Ma’ayan A, Rustogi N, Gottschalk MG, Webster MJ, Weickert CS, Buxbaum JD, Bahn S
PubMed ID: 30518843
ASF supported this research through a Post-Doctoral Training Award to Michael Breen.

Variability of urinary pesticide metabolite concentrations during pregnancy in the MARBLES Study
Barkoski J, Bennett D, Tancredi D, Barr DB, Elms W, Hertz-Picciotto I
PubMed ID: 29860212
ASF supported this research through a Pre-Doctoral Training Award to Jacqueline Barkoski.

Psychology

Age and Gender Effects on Intrinsic Connectivity in Autism Using Functional Integration and Segregation
Henry TR, Dichter GS, Gates K
PubMed ID: 29735152
ASF provided funding support to the Autism Brain Imaging Data Exchange.

Atypical Local and Distal Patterns of Occipito-frontal Functional Connectivity are Related to Symptom Severity in Autism
Jao Keehn RJ, Nair S, Pueschel EB, Linke AC, Fishman I, Müller RA
PubMed ID: 30137241
ASF supported this research through an Undergraduate Summer Research Grant to Ellyn Pueschel.

Atypicality of the N170 Event-Related Potential in Autism Spectrum Disorder: A Meta-analysis
Kang E, Keifer CM, Levy EJ, Foss-Feig JH, McPartland JC, Lerner MD
PubMed ID: 30092916
ASF supported this research through an Accelerator Award to Jennifer Foss-Feig.

Autistic traits modulate conscious and nonconscious face perception
Stavropoulos KKM, Viktorinova M, Naples A, Foss-Feig J, McPartland JC
PubMed ID: 27750521
ASF supported this research through a Post-Doctoral Training Award to Katherine Kuhl-Meltzoff Stavropoulos.

BEAPP: The Batch Electroencephalography Automated Processing Platform
Levin AR, Méndez Leal AS, Gabard-Durnam LJ, O’Leary HM
PubMed ID: 30131667
ASF supported this research through a Post-Doctoral Training Award to April Levin, an Undergraduate Summer Research Grant to Adriana Mendez Leal, and a Post-Doctoral Training Award to Laurel Joy Gabard-Durnam.

Characterising the relationship between theory of mind and anxiety in children with Autism Spectrum Disorder and typically developing children
Lei J, Ventola P
DOI: 10.1016/j.rasd.2018.01.005
ASF supported this research through an Enhancement Mini-Grant to Pamela Ventola.

Circumscribed Interests and Attention in Autism: The Role of Biological Sex
Harrop C, Jones D, Zheng S, Nowell S, Boyd BA, Sasson N
PubMed ID: 29777472
ASF supported this research through an Accelerator Award to Clare Harrop.

Deficits in mesolimbic reward pathway underlie social interaction impairments in children with autism
Supekar K, Kochalka J, Schaer M, Wakeman H, Qin S, Padmanabhan A, Menon V
PubMed ID: 30016410
ASF supported this research through a Post-Doctoral Training Award to Aarthi Padmanabhan.

Differences in praxis performance and receptive language during fingerspelling between deaf children with and without autism spectrum disorder
Bhat AN, Srinivasan SM, Woxholdt C, Shield A
PubMed ID: 29671643
ASF supported this research through an Enhancement Mini-Grant to Aaron Shield.

Electrophysiological response during auditory gap detection: Biomarker for sensory and communication alterations in autism spectrum disorder?
Foss-Feig JH, Stavropoulos, McPartland JC, Wallace MT, Stone WL, Key AP
PubMed ID: 29436853
ASF supported this research through an Accelerator Award to Jennifer Foss-Feig.

Encoding of Target Detection during Visual Search by Single Neurons in the Human Brain
Wang S, Mamelak AN, Adolphs R, Rutishauser U
PubMed ID: 29910078
ASF supported this research through a Post-Doctoral Training Award to Shuo Wang.

Hooked on a feeling: Repetitive cognition and internalizing symptomatology in relation to autism spectrum symptomatology
Keenan EG, Gotham K, Lerner MD
PubMed ID: 28747070
ASF supported this research through an Undergraduate Summer Research Grant to Elliot Keenan.

Learning an Embodied Visual Language: Four Imitation Strategies Available to Sign Learners
Shield A, Meier RP
PubMed ID: 29899716
ASF supported this research through an Enhancement Mini-Grant to Aaron Shield.

Modulation of reward in a live social context as revealed through interactive social neuroscience
Rolison MJ, Naples A, Rutherford HJV, McPartland JC
PubMed ID: 28586261
ASF supported this research through an Undergraduate Summer Research Grant to Max Rolison and an Enhancement Mini-Grant to Adam Naples.

Network-specific sex differentiation of intrinsic brain function in males with autism
Floris DL, Lai MC, Nath T, Milham MP, Di Martino A
PubMed ID: 29541439
ASF supported this research through a Post-Doctoral Training Award to Dorothea Floris.

Resting-state alpha power is selectively associated with autistic traits reflecting behavioral rigidity
Carter Leno V, Tomlinson SB, Chang SA, Naples AJ, McPartland JC
PubMed ID: 30097597
ASF supported this research through an Undergraduate Summer Research Grant to Sam Tomlinson.

Sensitivity to audio-visual synchrony and its relation to language abilities in children with and without ASD
Righi G, Tenenbaum EJ, McCormick C, Blossom M, Amso D, Sheinkopf SJ
PubMed ID: 29331093
ASF supported this research through a Post-Doctoral Training Award to Elena Tenenbaum.

Sensory reactivity, empathizing and systemizing in autism spectrum conditions and sensory processing disorder
Tavassoli T, Miller LJ, Schoen SA, Jo Brout J, Sullivan J, Baron-Cohen S
PubMed ID: 28579480
ASF supported this research through a Post-Doctoral Training Award to Teresa Tavassoli.

Sex differences in social attention in autism spectrum disorder
Harrop C, Jones D, Zheng S, Nowell S, Boyd BA, Sasson N
PubMed ID: 30403327
ASF supported this research through an Accelerator Award to Clare Harrop.

The Harvard Automated Processing Pipeline for Electroencephalography (HAPPE): Standardized Processing Software for Developmental and High-Artifact Data
Gabard-Durnam LJ, Méndez Leal AS, Wilkinson CL, Levin AR
PubMed ID: 29535597
ASF supported this research through a Post-Doctoral Training Award to April Levin.

Understanding Friendship Sex Heterophily and Relational Characteristics to Optimize the Selection of Peer Models for Children with Autism Spectrum Disorder
Locke J, Anderson A, Frederick L, Kasari C
PubMed ID: 29982894
ASF supported this research through an Early Career Award to Jill Locke.

Diagnosis

Diagnosis of Autism Spectrum Disorder After Age 5 in Children Evaluated Longitudinally Since Infancy
Ozonoff S, Young GS, Brian J, Charman T, Shephard E, Solish A, Zwaigenbaum L
PubMed ID: 30392626
ASF provided funding support to the Baby Siblings Research Consortium.

Treatment

Improvements in micro level indices of social communication following Pivotal Response Treatment (PRT)
Berman S, Ventola P, Gordon I
DOI: 10.1016/j.rasd.2018.04.003
ASF supported this research through an Enhancement Mini-Grant to Pamela Ventola.

The effects of intranasal oxytocin on reward circuitry responses in children with autism spectrum disorder
Greene RK, Spanos M, Alderman, Walsh E, Bizzell J, Mosner MG, Kinard JL, Stuber GD, Chandrasekhar T, Politte LC, Sikich L, Dichter GD
PubMed ID: 29587625
ASF supported this research through an Accelerator Award to Rachel Greene.

Therapeutic alliance in youth with autism spectrum disorder receiving cognitive-behavioral treatment for anxiety
Kerns CM, Collier A, Lewin AB, Storch EA 
PubMed ID: 28514865
ASF supported this research through an Accelerator Award to Connor Kerns.

Services

Factors impacting employment for people with autism spectrum disorder: A scoping review
Scott M, Milbourn B, Falkmer M, Black M, Bölte S, Halladay A, Lerner M, Taylor JL, Girdler S
PubMed ID: 30073870
ASF Chief Science Officer Alycia Halladay co-authored this publication.

It’s messy but real: a pilot study of the implementation of a social engagement intervention for children with autism in schools
Locke J, Kang-Yi CD, Pellecchia M, Mandell DS
DOI: 10.1111/1471-3802.12436
ASF supported this research through a Post-Doctoral Training Award and an Early Career Award to Jill Locke.

Parent–teacher problem solving about concerns in children with autism spectrum disorder: The role of income and race
Azad G, Gormley S, Marcus SC, Mandell DS
DOI: 10.1002/pits.22205
ASF supported this research through an Enhancement Mini-Grant to Gazi Azad.

Partners in School: An Innovative Parent-Teacher Consultation Model for Children with Autism Spectrum Disorder
Azad G, Marcus SC, Sheridan SM, Mandell DS
DOI: 10.1080/10474412.2018.1431550
ASF supported this research through an Enhancement Mini-Grant to Gazi Azad.

The impact of implementation support on the use of a social engagement intervention for children with autism in public schools
Locke J, Shih W, Kang-Yi CD, Caramanico J, Shingledecker T, Gibson J, Frederick L, Mandell DS
PubMed ID: 29998740
ASF supported this research through an Early Career Award to Jill Locke.