2020 Research Findings

The following studies co-authored by ASF grantees, whose names are underlined, were published in 2020. The grants awarded by ASF to fund these studies may have been distributed in years prior to 2020.

COVID

COVID-19 and Autism Research: Perspectives from Around the Globe.
Amaral DG, de Vries PJ
PubMed ID: 32592337
With contribution from Alison Singer.

Changes in access to educational and healthcare services for individuals with intellectual and
developmental disabilities during COVID-19 restrictions.

Jeste S, Hyde C, Distefano C, Halladay A, Ray S, Porath M, Wilson RB, Thurm A
PubMed ID: 32939917

Biology and Biomarkers

Autism BrainNet: a collaboration between medical examiners, pathologists, researchers, and families
to advance the understanding and treatment of autism spectrum disorder.

Anderson MP, Quinton R, Kelly K, Falzon A, Halladay A, Schumann C M, Hof PR, Tamminga CA, Hare CK,
Amaral DG

PubMed ID: 32960953

Large-scale analyses of the relationship between sex, age and intelligence quotient heterogeneity and
cortical morphometry in autism spectrum disorder.

Bedford SA, Park MTM, Devenyi GA, Tullo S, Germann J, Patel R, Anagnostou E, Baron-Cohen S, Bullmore
ET, Chura LR, Craig MC, Ecker C, Floris DL, Holt RJ, Lenroot R, Lerch JP, Lombardo MV, Murphy DGM,
Raznahan A, et al

PubMed ID: 31028290 2017
ASF supported this research through a Post-Doctoral Training Award to Dorothea Floris.

Transcriptional signatures of participant-derived neural progenitor cells and neurons implicate altered
Wnt signaling in Phelan-McDermid syndrome and autism.

Breen MS, Browne A, Hoffman GE, Stathopoulos S, Brennand K, Buxbaum JD, Drapeau E.
PubMed ID: 32560742
ASF supported this research through a Post-Doctoral Training Award to Michael Breen.

FOXP transcription factors in vertebrate brain development, function, and disorders.
Co M, Anderson AG, Konopka G
PubMed ID: 31999079
ASF supported this research through a Pre-Doctoral Training Award to Marissa Co.

Resting and Functional Pupil Response Metrics Indicate Features of Reward Sensitivity and ASD in
Children
.
DiCriscio AS, Troiani V
PubMed ID: 32978706
ASF supported this research through an Accelerator Award to Antionette Sabatino DiCriscio.

Atypical Brain Asymmetry in Autism—A Candidate for Clinically Meaningful Stratification.
Floris DL, Wolfers T, Zabihi M, Holz NE, Zwiers MP, Charman T, Tillmann J, Ecker C, Dell’Acqua F,
Banaschewski T, Moessnang C, Baron-Cohen S, Holt R, Durston S, Loth E, Murphy DGM, Marquand A,
Buitelaar JK, Beckmann CF, et al

PubMed ID: 33097470
ASF supported this research through a Post-Doctoral Training Award to Dorothea Floris.

Human in vitro models for understanding mechanisms of autism spectrum disorder.
Gordon A, Geschwind DH
PubMed ID: 32299488
ASF supported this research through a Post-Doctoral Training Award to Aaron Gordon.

Early restoration of shank3 expression in Shank3 knock-out mice prevents core asd-like behavioral
phenotypes
.
Jaramillo TC, Xuan Z, Reimers JM, Escamilla CO, Liu S, Powell CM
PubMed ID: 32327468
ASF supported this research through a Post-Doctoral Training Award to Christine Ochoa Escamilla.

Mutually suppressive roles of KMT2A and KDM5C in behaviour, neuronal structure, and histone H3K4
methylation.

Vallianatos CN, Raines B, Porter RS, Bonefas KM, Wu MC, Garay PM, Collette KM, Seo YA, Dou Y, Keegan
CE, Tronson NC, Iwase S

PubMed ID: 32483278
ASF supported this research through a Pre-Doctoral Training Award to Christina Vallianatos.

Whole-Genome and RNA Sequencing Reveal Variation and Transcriptomic Coordination in the
Developing Human Prefrontal Cortex

Werling DM, Pochareddy S, Choi J, An JY, Sheppard B, Peng M, Li Z, Dastmalchi C, Santpere G, Sousa
AMM, Tebbenkamp ATN, Kaur N, Gulden FO, Breen MS, Liang L, Gilson MC, Zhao X, Dong S, Klei L et al

PubMed ID: 32268104
ASF supported this research through Post-Doctoral Training Awards to Joon An, Michael Breen, and
Donna Werling.

Increased aperiodic gamma power in young boys with Fragile X Syndrome is associated with better
language ability.

Wilkinson CL, Nelson CA
PubMed ID: 33632320
ASF supported this research through a Post-Doctoral Training Award to Carol Wilkinson.

Evidence against the “normalization” prediction of the early brain overgrowth hypothesis of autism
Yankowitz LD, Herrington JD, Yerys BE, Pereira JA, Pandey J, Schultz RT
PubMed ID: 32552879
ASF supported this research through a Pre-Doctoral Training Award to Lisa Yankowitz.

Symmetric neural progenitor divisions require chromatin-mediated homologous recombination DNA
repair by Ino80.

Keil JM, Doyle DZ, Qalieh A, Lam MM, Funk OH, Qalieh Y, Shi L, Mohan N, Sorel A, Kwan KY
PubMed ID: 32737294
ASF supported this research through a Pre-Doctoral Training Award to Jason Keil.

Regulation of autism-relevant behaviors by cerebellar–prefrontal cortical circuits.
Kelly E, Meng F, Fujita H, Morgado F, Kazemi Y, Rice LC, Ren C, Escamilla CO, Gibson JM, Sajadi S, Pendry
RJ, Tan T, Ellegood J, Albert Basson M, Blakely RD, Dindot SV, Golzio C, Hahn MK, Katsanis N, et al

PubMed ID: 32661395
ASF supported this research through a Post-Doctoral Training Award to Christine Ochoa Escamilla.

Neuronal defects in a human cellular model of 22q11.2 deletion syndrome.
Kahn TA, Revah O, Gordon A, Yoon SJ, Krawisz AK, Goold C, Sun Y, Kim CH, Tian Y, Li MY, Schaepe JM,
Ikeda K, Amin ND, Sakai N, Yazawa M, Kushan L, Nishino S, Porteus MH, Rapoport JL, Bernstein JA,
O’Hara R, Bearden CE, Hallmayer JF, Huguenard JR, Geschwind DH, Dolmetsch RE, Paşca, SP

PubMed ID: 32989314
ASF supported this research through a Post-Doctoral Training Award to Aaron Gordon.

In utero pyrethroid pesticide exposure in relation to autism spectrum disorder (ASD) and other
neurodevelopmental outcomes at 3 years in the MARBLES longitudinal cohort.

Barkoski JM, Philippat C,Tancredi D, Schmidt RJ, Ozonoff S, Barr DB, Elms W,Bennett DH, Hertz-Picciotto I
PubMed ID: 33220244
ASF supported this research through a Pre-Doctoral Training Award to Jacqueline Barkoski.

Alterations in Retrotransposition, Synaptic Connectivity, and Myelination Implicated by
Transcriptomic Changes Following Maternal Immune Activation in Nonhuman Primates.

Page NF, Gandal MJ, Estes ML, Cameron S, Buth J, Parhami S, Ramaswami G, Murray K, Amaral DG, Van de Water
JA, Schumann CM, Carter CS, Bauman MD, McAllister AK, Geschwind DH

PubMed ID: 33386132
ASF supported this research through an Undergraduate Summer Research Grant to Nicholas Page.

The Presence of Another Person Influences Oscillatory Cortical Dynamics During Dual Brain EEG
Recording.

Rolison MJ, Napels AJ, Rutherford JHV, McPartland JC
PubMed ID: 32362842
ASF supported this research through an Enhancement Mini-Grant to Adam Naples and an
Undergraduate Research Grant to Max Rolison.

Treatments, Intervention and Services

Partners in School: An Implementation Strategy to Promote Alignment of Evidence-Based Practices
Across Home and School for Children with Autism Spectrum Disorder.

Azad GF, Minton KE, Mandell DS, Landa RJ
PubMed ID: 32653973
ASF supported this research through an Enhancement Mini-Grant to Gazi Azad.

Multi-informant International Perspectives on the Facilitators and Barriers to Employment for Autistic
Adults.

Black MH, Mahdi S, Milbourn B, Scott M, Gerber A, Esposito C, Falkmer M, Lerner MD, Halladay A, Strom
E, D’Angelo A, Falkmer T, Bölte S, Girdler S.

PubMed ID: 32170919
ASF supported this research through an Undergraduate Summer Research Award to Christopher
Esposito. ASF received additional support for this project through a grant from INSAR.

Examining Environmental Predictors of Community Participation for Adults with Autism Spectrum
Disorder Using Geographic Information Systems (GIS).

Chan DV, Klinger MR, Adkisson, KA, Klinger LG
PubMed ID: 32939608
ASF supported this research through an Accelerator Award to Dara Chan.

A Lifespan Approach to Patient-Reported Outcomes and Quality of Life for People on the Autism
Spectrum.

Graham Holmes L, Zampella CJ, Clements C, McCleery JP, Maddox BB, Parish-Morris J, Udhnani MD,
Schultz RT, Miller JS

PubMed ID: 32154664
ASF supported this research through a Post-Doctoral Training Award to Julia Paris-Morris.

Improved earlier diagnosis

Social language opportunities for preschoolers with autism: Insights from audio recordings in urban
classrooms.

Ferguson EF, Nahmias AS, Crabbe S, Liu T, Mandell DS, Parish-Morris J
PubMed ID: 31964156
ASF supported this research through a Post-Doctoral Training Award to Julia Paris-Morris.

Age of walking and intellectual ability in autism spectrum disorder and other neurodevelopmental
disorders: a population-based study.

Havdahl A, Farmer C, Schjølberg S, Øyen AS, Surén P, Reichborn-Kjennerud T, Magnus P, Bresnahan M,
Hornig M, Susser E, Lipkin WI, Lord C, Stoltenberg C, Thurm A, Bishop S

PubMed ID: 33369747
ASF supported this research through an Autism Sisters Project grant to Somer Bishop.

Trajectories of Posture Development in Infants With and Without Familial Risk for Autism Spectrum
Disorder.

Leezenbaum NB, Iverson JM
PubMed ID: 31079276
ASF supported this research through a Pre-Doctoral Training Award to Nina Leezenbaum.

Can Familial Risk for ADHD Be Detected in the First Two Years of Life?
Miller M, Iosif AM, Bell LJ, Farquhar-Leicester A, Hatch B, Hill A, Hill MM, Solis E, Young GS, Ozonoff S
PubMed ID: 31951755
ASF supported this research through an Undergraduate Summer Research Award to Laura Bell.

EEG-IP: An international infant EEG data integration platform for the study of risk and resilience in
autism and related conditions.

Van Noordt S, Desjardins JA, Huberty S, Abou-Abbas L, Webb SJ, Levin AR, Segalowitz SJ, Evans AC,
Elsabbagh M

PubMed ID: 32380941
ASF supported this research through a Post-Doctoral Training Award to April Levin.

Developmental Trajectories of Infants with Multiplex Family Risk for Autism: A Baby Siblings Research
Consortium Study

McDonald NM, Senturk D, Scheffler A, Brian JA, Carver LJ, Charman T, Chawarska K, Curtin S, Hertz-
Piccioto I, Jones EJH, Klin A, Landa R, Messinger DS, Ozonoff S, Stone WL, Helen Tager-Flusberg H, Webb
SJ, Young G, Zwaigenbaum L, Jeste, SS

PubMed ID: 31589284
ASF supported this research through a BSRC Database Grant to Greg Young.

Understanding comorbidities

Increased pain sensitivity and pain-related anxiety in individuals with autism.
Failla MD, Gerdes MB, Williams ZJ, Moore DJ, Cascio CJ
PubMed ID: 33235944
ASF supported this research through a Post-Doctoral Training Award to Michelle Failla.

Gender differences

Inherited Risk for Autism Through Maternal and Paternal Lineage.
Bai D, Marrus N, Yip BHK, Reichenberg A, Constantino JN, Sandin S
PubMed ID: 32430199
ASF supported this research through a Post-Doctoral Training Award to Natasha Marrus.

Sex differences in scores on standardized measures of autism symptoms: a multisite integrative data
analysis.

Kaat AJ, Shui AM, Ghods SS, Farmer CA, Esler AN, Thurm A, Georgiades S, Kanne SM, Lord C, Kim YS,
Bishop SL

PubMed ID: 32314393
ASF supported this research through an Autism Sisters Project grant to Somer Bishop.

Brain function distinguishes female carriers and non-carriers of familial risk for autism.
Eggebrecht AT, Dworetsky A, Hawks Z, Coalson R, Adeyemo B, Davis S, Gray D, McMichael A, Petersen
SE, Constantino JN, Pruett JR

PubMed ID: 33081838
ASF supported this research through a Pre-Doctoral Training Award to Zoe Hawks.

Large-Scale Exome Sequencing Study Implicates Both Developmental and Functional Changes in the
Neurobiology of Autism.

Satterstrom FK, Kosmicki JA, Wang J, Breen MS, De Rubeis S, An JY, Peng M, Collins R, Grove J, Klei L,
Stevens C, Reichert J, Mulhern MS, Artomov M, Gerges S, Sheppard B, Xu X, Bhaduri A, Norman U, et al
PubMed ID: 31981491

ASF supported this research through Post-Doctoral Training Awards to Joon An and Michael Breen
through the Autism Sisters Project.