2021 Research Findings

The following 36 studies co-authored by ASF grantees, whose names are underlined, were published in 2021. The grants awarded by ASF to fund these studies may have been distributed in years prior to 2021.  

COVID-19 Pandemic

A lost generation? The impact of the COVID‐19 pandemic on early career ASD researchers.
Harrop C, Bal V, Carpenter K, Halladay A
PubMed ID: 33759380
ASF supported this research with contribution from Alycia Halladay.

Rethinking autism spectrum disorder assessment for children during COVID ‐19 and beyond. 
Zwaigenbaum L, Bishop S, Stone WL, Ibanez L, Halladay A, Goldman S, Kelly A, Klaiman C, Lai M, Miller M, Saulnier C, Siper P, Sohl K, Warren Z, Wetherby A
PubMed ID: 34553489
ASF supported this research with contribution from Alycia Halladay.

Biology and Biomarkers

Autism risk in offspring can be assessed through quantification of male sperm mosaicism. 
Breuss MW, Antaki D, George RD, Kleiber M, James KN, Ball LL, Hong O, Mitra I, Yang X, Wirth SA, Gu J, Garcia CAB, Gujral M, Brandler WM, Musaev D, Nguyen A, McEvoy-Venneri J, Knox R, Sticca E, Botello MCC, Fenner JU, Perez MC, Arranz M, Moffitt AB, Wang Z, Hervas A, Devinsky O, Gymrek M, Sebat J, Gleeson JG
PubMed ID: 31873310
ASF supported this research through a Post-Doctoral Training Award to William Brandler.

Comprehensive Assessment of Visual Perceptual Skills in Autism Spectrum Disorder. 
DiCriscio AS, Smith J, Troiani V
PubMed ID: 34326793
ASF supported this research through an Accelerator Award to Antoinette Sabatino DiCriscio.

Abnormally Large Baseline P300 Amplitude Is Associated with Conversion to Psychosis in Clinical High Risk Individuals with a History of Autism: A Pilot Study. 
Foss-Feig JH, Guillory SB, Roach BJ, Velthorst E, Hamilton H, Bachman P, Belger A, Carrion R, Duncan E, Johannesen J, Light GA, Niznikiewicz M, Addington JM, Cadenhead KS, Cannon TD, Cornblatt B, McGlashan T, Perkins D, Seidman LJ, Stone WS, Tsuang M, Walker EF, Woods S, Bearden CE, Mathalon DH
PubMed ID: 33633603
ASF supported this research through an Accelerator Award to Jennifer Foss-Feig.

Long-term maturation of human cortical organoids matches key early postnatal transitions.
Gordon A, Yoon SJ, Tran SS, Makinson CD, Park JY, Andersen J, Valencia AM, Horvath S, Xiao X, Huguenard JR, Pasca SP, Geschwind DH
PubMed ID: 33619405
ASF supported this research through a Post-Doctoral Training Award to Aaron Gordon.

Brief Report: Preliminary Evidence of the N170 as a Biomarker of Response to Treatment in Autism Spectrum Disorder.
Kala S, Rolison MJ, Trevisan DA, Naples AJ, Pelphrey K, Ventola P, McPartland JC
PubMed ID: 34267691
ASF supported this research through an Undergraduate Research Grant to Max Rolison.

Investigating the Neurobiology of Abnormal Social Behaviors.
Li SW, Williams ZM, Báez-Mendoza R
PubMed ID: 34916912
ASF supported this research through a Pre-Doctoral Training Award to S William Li.

Alterations in Retrotransposition, Synaptic Connectivity, and Myelination Implicated by Transcriptomic Changes Following Maternal Immune Activation in Nonhuman Primates. 
Page NF, Gandal MJ, Estes ML, Cameron S, Ruth J, Parhami S, Ramaswami G, Murray K, Amaral DG, Van de Water JA, Schumann CM, Carter CS, Bauman MD, McAllister AK, Geschwind DH
PubMed ID: 33386132
ASF supported this research through an Undergraduate Research Award to Nicholas Page.

Atypical Visual Motion-Prediction Abilities in Autism Spectrum Disorder. 
Park WJ, Schauder KB, Kwon OS, Bennetto L, Tadin D
PubMed ID: 34721951
ASF supported this research through a Pre-Doctoral Training Award to Woon Ju Park.

Increased aperiodic gamma power in young boys with Fragile X Syndrome is associated with better language ability.
Wilkinson CL, Nelson CA
PubMed ID: 33632320
ASF supported this research through a Post-Doctoral Award to Carol Wilkinson.

Using head-mounted eye tracking to examine visual and manual exploration during naturalistic toy play in children with and without autism spectrum disorder. 
Yurkovic JR, Lizandrelli G, Shaffer RC, Dominick KC, Pedapati EV, Erickson CA, Kennedy DP, Yu C
PubMed ID: 33574367
ASF supported this research through a Pre-Doctoral Training Award to Julia Yurkovic.

Gender differences

Signaling Pathways and Sex Differential Processes in Autism Spectrum Disorder.
Enriquez KD, Gupta AR, Hoffman EJ
PubMed ID: 34690830
ASF supported this research through an Undergraduate Research Award to Kristen Enriquez.

Towards robust and replicable sex differences in the intrinsic brain function of autism. 
Floris DL, Filho JOA, Lai MC, Giavasis S, Oldehinkel M, Mennes M, Charman T, Tillmann J, Dumas G, Ecker C, Dell’Acqua F, Banaschewski T, Moessnang C, Baron-Cohen S, Durston S, Loth E, Murphy DGM, Buitelaar JK, Beckman CF, Milham MP, Di Martino A
PubMed ID33648569
ASF supported this research through a Post-Doctoral Training Award to Dorothea Floris.

Genetics, gene/environment interactions, and utility of genetic findings

In utero pyrethroid pesticide exposure in relation to autism spectrum disorder (ASD) and other neurodevelopmental outcomes at 3 years in the MARBLES longitudinal cohort.
Barkoski JM, Philippat C, Tancredi D, Schmidt RJ, Ozonoff S, Barr DB, Elms W, Bennett DH, Hertz-Picciotto I
PubMed ID: 33220244
ASF supported this research through a Pre-Doctoral Training Award to Jacqueline Barkoski.

Repeat DNA expands our understanding of autism spectrum disorder. 
Hannan AJ
PubMed ID: 33442037
ASF supported this research through a Post-Doctoral Training Award to Ileena Mitra.

Reduced sociability and social agency encoding in adult Shank3-mutant mice are restored through gene re-expression in real time. 
Lee DK, Li SW, Bounni F, Friedman G, Jamali M, Strahs L, Zeliger O, Gabrieli P, Stankovich MA, Demaree J, Williams ZM
PubMed ID: 34253921
ASF supported this research through a Pre-Doctoral Training Award to S William Li.

Genetic counseling as preventive intervention: Toward individual specification of transgenerational autism risk. 
Marrus N, Turner TN, Forsen E, Bolster D, Marvin A, Whitehouse A, Klinger L, Gurnett CA, Constantino JN
PubMed ID: 34530736
ASF supported this research through a Post-Doctoral Training Award to Natasha Marrus.

Patterns of de novo tandem repeat mutations and their role in autism.
Mitra I, Huang B, Mousavi N, Ma N, Lamkin M, Yanicky R, Shleizer-Burko S, Lohmueller KE, Gymrek M
PubMed ID: 33442040
ASF supported this research through a Post-Doctoral Training Award to Ileena Mitra.

Considering Toxic Chemicals in the Etiology of Autism.
Volk HE, Ames JL, Chen A, Fallin MD, Hertz-Picciotto I, Halladay A, Hirtz D, Lavin A, Ritz B, Zoeller T, Swanson M
PubMed ID: 34972219
ASF supported this research with contribution from Alycia Halladay.

Patterns of delay in early gross motor and expressive language milestone attainment in probands with genetic conditions versus idiopathic ASD from SFARI registries. 
Wickstrom J, Farmer C, Green Snyder L, Mitz AR, Sanders SJ, Bishop S, Thurm A
PubMed ID: 34382689
ASF supported this research through an Autism Sisters Project grant to Somer Bishop.

Improved Earlier Diagnosis

Onset, Trajectory, and Pattern of Feeding Difficulties in Toddlers Later Diagnosed with Autism. 
Ashley K, Steinfeld MB, Young GS, Ozonoff S
PubMed ID: 31800528
ASF supported this research through a Baby Siblings Research Consortium grant to Gregory Young.

Age of walking and intellectual ability in autism spectrum disorder and other neurodevelopmental disorders: A population‐based study. 
Havdahl A, Farmer C, Schjølberg S, Øyen A, Surén P, Reichborn-Kjennerud T, Magnus P, Bresnahan M, Hornig M, Susser E, Lipkin WI, Lord C, Stoltengerg C, Thurm A, Bishop S
PubMed ID: 33369747
ASF supported this research through an Autism Sisters Project grant to Somer Bishop.

12-Month peak alpha frequency is a correlate but not a longitudinal predictor of non-verbal cognitive abilities in infants at low and high risk for autism spectrum disorder.
Carter Leno V, van Noordt S, Huberty S, Desjardins J, Webb SJ, Elsabbagh M, the BASIS team
PubMed ID: 33714056
ASF supported this research through a funding to Sara Jane Webb.

A prospective evaluation of infant cerebellar-cerebral functional connectivity in relation to behavioral development in autism. 
Hawks ZW, Todorov A, Marrus N, Nishino T, Talovic M, Nevel MB, Girault JB, Davis S, Marek S, Seitzman BA, Eggebrecht AT, Elison J, Dager S, Mosconi MW, Tyschsen L, Snyder AZ, Botteron K, Estes A, Evans A, Gerig G, Hazlett HC, McKinstry RC, Pandey J, Schultz R, Styner M, Wolff JJ, Zwaigenbaum L, Markson L, Petersen SE, Constantino JN, White, DA, Piven J, Pruett J, the IBIS Network
DOI: doi.org/10.1016/j.bpsgos.2021.12.004
ASF supported this research through a Pre-Doctoral Training Award to Zoë Hawks.

Infant vocalizing and phenotypic outcomes in autism: Evidence from the first 2 years.
Plate S, Yankowitz L, Resorla L, Swanson MR, Meera SS, Estes A, Marrus N, Cola M, Petrilla V, Faggen A, Pandey J, Paterson S, Pruett JR, Hazlett H, Dager S, St John T, Botteron K, Zwaigenbaum L, Piven J, Schultz RT, Parish-Morris J, IBIS Network
PubMed ID: 34708871
ASF supported this research through a Pre-Doctoral Training Award to Lisa Yankowitz.

Parental Language Input Predicts Neuroscillatory Patterns Associated with Language Development in Toddlers at Risk of Autism. 
Romeo RR, Choi B, Gabard-Durnam LJWikinson CLLevin AR, Rowe ML, Tager-Flusberg H, Nelson CA
PubMed ID: 34185234
ASF supported this research through Post-Doctoral Training Awards to Laurel Gabard-Durnam, Carol Wilkinson, and April Levin.

Prediction of autism spectrum disorder diagnosis using nonlinear measures of language-related EEG at 6 and 12 months.
Peck FC, Gabard-Durnam LJWilkinson CL, Bosl W, Tager-Flusberg H, Nelson CA
PubMed ID: 34847887
ASF supported this research through a Post-Doctoral Training Award to Laurel Gabard-Durnam and Carol Wilkinson

Underresearched groups

The Lancet Commission on the future of care and clinical research in autism. 
Lord C, Charman T, Havdahl A, Carbone P, Anagnostou E, Boyd B, Carr T, de Vries PJ, Dissanayake C, Divan G, Freitag CM, Gotelli MM, Kasari C, Knapp M, Mundy P, Plank S, Scahill L, Servili C, Shattuck P, Simonoff E, Singer AT, Slonims V, Wang PP, Ysrraelit MC, Jellett R, Pickles A, Cusack J, Howlin P, Szatmari P, Holbrook A, Toolan C, McCauley JB
PubMed ID: 34883054
ASF supported this research with contribution from Alison Singer.

Barriers, and Possible Solutions: Steps Towards Addressing Autism Researchers Under-Engagement with Racially, Ethnically, and Socioeconomically Diverse Communities.
Maye M, Boyd BA, Martinez-Pedraza F, Halladay A, Thurm A, Mandell DS
PubMed ID: 34529251
ASF supported this research with contribution from Alycia Halladay.

Making Research Possible: Barriers and Solutions For Those With ASD and ID.
Thurm A, Halladay A, Mandell D, Maye M, Ethridge S, Farmer C
PubMed ID: 34716842
ASF supported this research with contribution from Alycia Halladay.

Treatments, interventions and services

Partners in School: An Implementation Strategy to Promote Alignment of Evidence-Based Practices Across Home and School for Children with Autism Spectrum Disorder.
Azad GF, Minton KE, Mandell DS, Landa RJ
PubMed ID: 32653973
ASF supported this research through an Accelerator Award to Gazi Azad.

Examining Environmental Predictors of Community Participation for Adults with Autism Spectrum Disorder Using Geographic Information Systems (GIS). 
Chan DV, Klinger MR, Adkisson KA, Klinger LG
PubMed ID: 32939608
ASF supported this research through an Accelerator Award to Dara Chan.

Let’s See That Again: Using Instructional Videos to Support Asynchronous Mathematical Problem Solving Instruction for Students With Autism Spectrum Disorder.
Cox SK, Root JR, Gilley D
DOI: doi.org/10.1177/0162643421996327
ASF supported this research through an Accelerator Award to Jenny Root.

Building Comprehension Skills of Young Children With Autism One Storybook at a Time. 
Fleury VP, Whalon K, Gilmore C, Wang X, Marks R
PubMed ID: 33464976
ASF supported this research through an Accelerator Award to Veronica Fleury.

Understanding comorbidities

Predictors of Suicidal Thoughts in Children with Autism Spectrum Disorder and Anxiety or Obsessive-Compulsive Disorder: The Unique Contribution of Externalizing Behaviors. 
La Buissonnière Ariza V, Scheider SC, Cepeda SL, Wood JJ, Kendall PC, Small BJ, Wood KS, Kerns C, Saxena K, Storch EA
PubMed ID: 33462740
ASF supported this research through an Accelerator Award to Connor Kerns.