Lots of people tend to think of the genetics of disorders/disease as being one mutation/genetic variation inherited from the mother/father that causes a trait directly. Unfortunately, the genetics of autism isn’t that simple or scientists would have found “the gene” by now. In fact, there are different types of genetic influences in autism. A new study in Nature Genetics led by Elise Robinson shows how common variation influences autism risk, as well as intellectual function in autism, compared to de novo mutations. There is a short primer at the beginning of the podcast about old-school genetic thinking and why it doesn’t apply to ASD.