Can Brain Size Predict Autism? Building a model system with iPSC-derived cortical organoids

Brain imaging studies of infants with autism have shown a faster rate of expansion of a layer of the brain called the cortex in those who go on to be diagnosed with autism. Some infants also exhibit macrocephaly (larger than expected overall brain size). However, little is known about these features in autism. This study will develop a new model system utilizing organoids, which are aggregates of cells obtained directly from individual study participants and then further manipulated in a dish to recreate the cortex. In this way, scientists can understand how cells divide, expand, and grow. This researcher will then compare features in the organoids with brain scans collected from the same individual. This work will provide the research community with a novel way to test therapies and interventions on those with macrocephaly.